Translocation t(14;18) is not associated with inferior outcome in chronic lymphocytic leukemia

In non‐follicular lymphoproliferative disorders, IGH/BCL2‐fusion is not restricted to chronic lymphocytic leukaemia

“…In agreement with previous series (Sen et al, 2002;Put et al, 2009), the IGH/BCL2 fusion was remarkably associated with trisomy 12, and this association appeared more frequently than in common CLL series. The atypical cytology (increased number of lymphoid cells with irregular nuclear contours, plasmacytoid features or prolymphocytes) and/or an atypical CLL profile (lack of CD23 and intermediate/strong CD20 expression) is probably linked to trisomy 12, as has been previously reported (Matutes et al, 1996).…”

“…In contrast to the BCL3 translocations that have been reported in CLL and in a heterogeneous group of B-cell malignancies (Huh et al, 2007;Martín-Subero et al, 2007;Chapiro et al, 2008), the IGH/BCL2 fusion, other than FL and DLCBL, has been described in only a few CLL series (Sen et al, 2002;Cavazzini et al, 2008;Lau et al, 2008;Put et al, 2009) and in occasional cases of mucosa associated lymphoid tissue (MALT) lymphomas (Nakamura et al, 2007;Palmedo et al, 2007). To more clearly define whether the IGH/BCL2 translocation is restricted to CLL or whether it may be observed in other chronic B-cell lymphoproliferative diseases (CLPD) with usual or frequent disseminated presentation, we analysed the prevalence of IGH/BCL2 translocations using conventional cytogenetics of a consecutive series of non-FL B-cell neoplasm studied in peripheral blood.…”

“…For better clarity, we decided to present our results in three parts. The first part includes (i) CLL/MBL cases that can be compared with CLL without a IGH/BCL2 translocation (referred in the present text as common CLL) and with previously reported cases of CLL with IGH/BCL2 translocation (Sen et al, 2002;Lau et al, 2008;Put et al, 2009), and (ii) SLL cases. The second part relates to the SMZL case, and the third consists of the U-CLPD cases.…”

“…The t(14;19) translocation involving BCL3 is widely described in the literature and is often associated with atypias in morphology as well as in immunological profile, with unmutated IGHV genes and a poorer prognosis than common CLL (Huh et al, 2007;Martín-Subero et al, 2007;Cavazzini et al, 2008;Chapiro et al, 2008). The involvement of BCL2 for balanced immunoglobulin gene translocations in CLL has been less frequently reported (Sen et al, 2002;Lau et al, 2008;Put et al, 2009). Different clinical behaviours have been reported, which may be related to grouping the t(14;18) and t(14;19) translocations together in one report (Lau et al, 2008).…”

Genetics of Chronic Lymphocytic Leukemia: Practical Aspects and Prognostic Significance

“…monosomy) of 17, del(11q) complex karyotype, additional unbalanced translocations and poor prognosis (Put et al, 2011). In contrast, translocations involving BCL2 are associated with mutated IGVH genes, trisomy 12, absence of del(11q) and more favorable outcome (Put et al, 2009b). …”