Transmission electron microscopy and the molecular structure of icosahedral viruses

Martín, Carmen San

doi:10.1016/j.abb.2015.06.001

Cited by 6 publications

(2 citation statements)

References 125 publications

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“…VIII molecules outline the GON and help to stabilize hexons on the inside of the capsid. Protein VI also stabilizes hexon by binding the hexon trimer central cavity exposed to the inner viral lumen [ 42 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties

Daussy

Pied

Wodrich

2021

Viruses

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Adenovirus vector-based genetic vaccines have emerged as a powerful strategy against the SARS-CoV-2 health crisis. This success is not unexpected because adenoviruses combine many desirable features of a genetic vaccine. They are highly immunogenic and have a low and well characterized pathogenic profile paired with technological approachability. Ongoing efforts to improve adenovirus-vaccine vectors include the use of rare serotypes and non-human adenoviruses. In this review, we focus on the viral capsid and how the choice of genotypes influences the uptake and subsequent subcellular sorting. We describe how understanding capsid properties, such as stability during the entry process, can change the fate of the entering particles and how this translates into differences in immunity outcomes. We discuss in detail how mutating the membrane lytic capsid protein VI affects species C viruses’ post-entry sorting and briefly discuss if such approaches could have a wider implication in vaccine and/or vector development.

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Section: Introductionmentioning

confidence: 99%

Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties

Daussy

Pied

Wodrich

2021

Viruses

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“…Classical applications for the study of helical particles, icosahedral virus reconstruction, and two-dimensional crystals are reviewed, respectively, by Edward Egelman, Carmen San Martín, Andreas Engel and Hennig Stahlberg [6,7,8]. These well-known experts in their respective areas present the evolution from the historical background of the pioneering publications to the incorporation of atomic resolution in recent papers, and highlight EM's unique possibilities for the resolution of large, very complex macromolecular complexes.…”

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confidence: 98%