Transmission of Ehrlichia canis by Rhipicephalus sanguineus ticks feeding on dogs and on artificial membranes

Fourie, Josephus J.; Stanneck, Dorothee; Luus, H. G.; Beugnet, Frédéric; Wijnveld, Michiel; Jongejan, Frans

doi:10.1016/j.vetpar.2013.07.026

Cited by 90 publications

(67 citation statements)

References 26 publications

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“…anatolicum excavatum ) (Habedank, Hiepe & Montag, 1994) and all life stages of Amblyomma hebraeum Koch, 1844 (Kuhnert, Diehl & Guerin, 1995) and Ixodes ricinus (Kroeber & Guerin, 2007). Even though the technique must be adapted and modified for use with each tick species according to the length of the mouthparts (Kroeber & Guerin, 2007), examples of successful feeding of other species such as Rhipicephalus sanguineus Latreille, 1806, Hyalomma dromedarii Koch, 1844 and H. anatolicum Koch, 1844 (formerly H. anatolicum anatolicum ) (Tajeri & Razmi, 2011; Fourie et al ., 2013) suggest this is a useful approach for cement research (Fig. 1).…”

Section: Historical Perspective On Cement Researchmentioning

confidence: 99%

Tick attachment cement – reviewing the mysteries of a biological skin plug system

et al. 2017

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The majority of ticks in the family Ixodidae secrete a substance anchoring their mouthparts to the host skin. This substance is termed cement. It has adhesive properties and seals the lesion during feeding. The particular chemical composition and the curing process of the cement are unclear. This review summarizes the literature, starting with a historical overview, briefly introducing the different hypotheses on the origin of the adhesive and how the tick salivary glands have been identified as its source. Details on the sequence of cement deposition, the curing process and detachment are provided. Other possible functions of the cement, such as protection from the host immune system and antimicrobial properties, are presented. Histochemical and ultrastructural data of the intracellular granules in the salivary gland cells, as well as the secreted cement, suggest that proteins constitute the main material, with biochemical data revealing glycine to be the dominant amino acid. Applied methods and their restrictions are discussed. Tick cement is compared with adhesives of other animals such as barnacles, mussels and sea urchins. Finally, we address the potential of tick cement for the field of biomaterial research and in particular for medical applications in future.

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Section: Historical Perspective On Cement Researchmentioning

confidence: 99%

Tick attachment cement – reviewing the mysteries of a biological skin plug system

et al. 2017

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“…Several studies have been conducted to assess the time necessary for pathogen transmission [9,[19][20][21]. Infected ticks were allowed to feed on host animals for defined time periods.…”

Section: Discussionmentioning

confidence: 99%

“…A better approach is the use of treatments capable of repelling, or rapidly killing ticks prior to transmission, ideally with a long duration of efficacy [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

Wengenmayer¹,

Williams²,

Zschiesche³

et al. 2014

Parasites & Vectors

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Background: Pathogens that are transmitted by ticks to dogs, such as Anaplasma phagocytophilum, Babesia spp., Borrelia burgdorferi sensu latu, and Ehrlichia canis, are an increasing problem in the world. One method to prevent pathogen transmission to dogs is to kill the ticks before transmission occurs. Fluralaner (Bravecto™) is a novel isoxazoline insecticide and acaricide that provides long persistent antiparasitic activity following systemic administration. This study investigated the speed of kill of fluralaner against Ixodes ricinus ticks on dogs.

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“…Repellency and/or a rapid speed of kill are more important now than ever before. Ticks may transmit pathogens to hosts much faster than previously considered (Fourie et al 2013b). Recommendations from the Canine Vector-Borne Disease world forum in 2011 (CVBD) note that pathogen transmission can occur almost immediately from …”

Section: S103mentioning

confidence: 96%

Comparative Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and an Oral Fluralaner Chewable Tablet (Bravecto®) against Tick (Dermacentor variabilis and Amblyomma americanum) Infestations on Dogs: a Randomised Controlled Trial

et al. 2015

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This controlled laboratory study demonstrated the residual speed of efficacy of an imidacloprid/ flumethrin collar (Seresto ® , Bayer) for the control of ticks (Dermacentor variabilis, Amblyomma americanum) at 6 and 12 hours post-infestation on dogs when compared to oral fluralaner (Bravecto ® , Merck). Dogs were randomised by pre-treatment tick counts: Group 1) imidacloprid 10 % (w/w)/ flumethrin 4.5 % (w/w) collar, 2) fluralaner (dosage 25.1 -49.4 mg/kg), and 3) non-treated controls. Ticks (50/species/dog) were infested on days 3, 14, 21, 28, 42, and 56 followed by 50 D. variabilis on days 70 and 84. Live and dead attached ticks were counted 6 and 12 hours later. Efficacy against both species at 6 and 12 hours for Group 1 was 94 -100 %. Efficacy for Group 2 against both species at 6 hours was 4 -69 %; efficacy at 12 hours was 8 -100 %. Live (attached and non-attached) tick counts at 6 hours in Group 1 were significantly lower (p ≤ 0.05) than counts in Group 2 and 3 on all days. At 12 hours, live counts were significantly lower (p ≤ 0.05) in Group 1 than Group 2 for D. variabilis from days 56 -84 and for A. americanum from days 28 -56. There were significantly fewer (p ≤ 0.05) total ticks (total live and dead attached) on dogs in Group 1 compared to Group 2 and 3 at all time points. This study demonstrated that an imidacloprid/flumethrin collar was highly efficacious (94 -100 %) at repelling and killing ticks on dogs at 6 and 12 hours post-infestation and was more efficacious than fluralaner as early as 6 hours post-infestation on all challenge days. S95Ectopar asitEs

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Transmission of Ehrlichia canis by Rhipicephalus sanguineus ticks feeding on dogs and on artificial membranes

Cited by 90 publications

References 26 publications

Tick attachment cement – reviewing the mysteries of a biological skin plug system

Tick attachment cement – reviewing the mysteries of a biological skin plug system

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

Comparative Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and an Oral Fluralaner Chewable Tablet (Bravecto®) against Tick (Dermacentor variabilis and Amblyomma americanum) Infestations on Dogs: a Randomised Controlled Trial

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