1984
DOI: 10.1126/science.6093251
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Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDS

Abstract: Two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (AIDS) or pre-AIDS showed serum antibodies to type III human T-cell leukemia virus (HTLV-III) 10 to 12 weeks after transfusion. One animal also developed lymphadenopathy, transient depression of the ratio of T4 to T8 lymphocytes, and impaired blastogenic responses. No opportunistic infections occurred. Adenopathy persisted for 32 weeks, and antibody to HTLV-III persisted for at least 48 weeks. This transmission of HTLV… Show more

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Cited by 296 publications
(98 citation statements)
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“…Rapid progress in the development of a protective vaccine against HIV has been impaired by the lack of a suitable and cost-effective animal model. Successful infection of non-human primates has been achieved only in chimpanzees (43) and gibbons (P. Markham, personal communication), which are scarce, and to date these animals have not developed AIDS. Since the parental HIV-2SBL6669 and the molecular clone HIV-2sBL/ISy productively infect rhesus macaques (unpublished results) and since macaques are sensitive to the pathogenic effect of SIVmac, the development of an animal model using a highly related human virus will obviously be very valuable.…”
Section: Methodsmentioning
confidence: 99%
“…Rapid progress in the development of a protective vaccine against HIV has been impaired by the lack of a suitable and cost-effective animal model. Successful infection of non-human primates has been achieved only in chimpanzees (43) and gibbons (P. Markham, personal communication), which are scarce, and to date these animals have not developed AIDS. Since the parental HIV-2SBL6669 and the molecular clone HIV-2sBL/ISy productively infect rhesus macaques (unpublished results) and since macaques are sensitive to the pathogenic effect of SIVmac, the development of an animal model using a highly related human virus will obviously be very valuable.…”
Section: Methodsmentioning
confidence: 99%
“…Chimpanzees are the only species that have become infected experimentally upon inoculation with the human immunodeficiency virus (HIV) (Alter et al, 1984;Fultz et al, 1986). Although this chimpanzee model will undoubtedly be used in a variety of studies relating to AIDS, particularly those involving vaccine development, it has a number of severe limitations.…”
Section: Long-term Persistent Infection Of Macaque Monkeys With the Smentioning
confidence: 99%
“…The species tropism of HIV-1 is narrower than that of viruses of the HIV-2 subgroup (HIV-2, SIV~A c and SIVMN E of the macaque monkey and SIVsM of the sooty mangabey, Cercocebus atys). Only higher primates [humans, chimpanzees (Pan troglodytes), gibbons (Hylobates lar)] and pig-tailed macaques (M. nemestrina) are susceptible to HIV-1 infection in vivo (Agy et al, 1992;Alter et al, 1984;Fultz et al, 1986;Gajdusek et al, 1985;Lusso et al, 1988;Nara et al, 1987), whereas various primates [humans, rhesus monkeys (Macaca mulatta), cynomolgus monkeys (M. fascicularis), pig-tailed monkeys, and sooty mangabeys] are productively infected with viruses of the HIV-2 subgroup (Benveniste et al, 1988;Daniel et al, 1985;Dewhurst et al, 1990;Franchini et al, 1990;Letvin et al, 1985;Naidu et al, 1988). In cultured peripheral blood mononuclear cells (PBMC), growth of HIV-1 is similarly restricted .…”
Section: Introductionmentioning
confidence: 99%