2009
DOI: 10.1002/lt.21756
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Transmission of human immunodeficiency virus and hepatitis C virus through liver transplantation

Abstract: TO THE EDITORS:We are writing in regard to a recently published article by Ahn and Cohen documenting the transmission of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) to a liver recipient, 2 kidney recipients, and 1 heart recipient. 1 The authors clearly present the case from their patients' perspective, allowing the transplant community to review many of the facts regarding their care. The authors state in the abstract and in the discussion that the transmission occurred secondary to the dono… Show more

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Cited by 13 publications
(18 citation statements)
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“…However, the transmission of HIV and HCV to four patients undergoing solid organ transplantation from a DIRVI in 2007 drew public attention to the possible negative consequences of accepting organs from these donors. (911)…”
Section: Introductionmentioning
confidence: 99%
“…However, the transmission of HIV and HCV to four patients undergoing solid organ transplantation from a DIRVI in 2007 drew public attention to the possible negative consequences of accepting organs from these donors. (911)…”
Section: Introductionmentioning
confidence: 99%
“…Two of our cases were HIV Ab−/NAT+ which raises the possibility of a potential window period infection or a false negative serology due to hemodilution(23). In the case of an acutely-infected HIV+ donor, a quantitative PCR result would generally be high as HIV RNA levels in acute infection can typically be over 1 million copies/mL of plasma (2426).…”
Section: Discussionmentioning
confidence: 98%
“…Seroconversion of transplant recipients may be impeded by the immunosuppressive medications the patients receive. 29,222,223 In most cases of known donor-derived HCV transmission, recipients failed to seroconvert to HCV seropositive status despite having high viral titers by NAT. 29,221,223 Likewise, in the confirmed HIV/HCV donor-derived transmission, one in four patients had an indeterminate Western blot.…”
Section: Vii: Expert Opinion Summariesmentioning
confidence: 99%