Transmission of IMI-2 carbapenemase-producing Enterobacteriaceae from river water to human

Laurens, C.; Jean-Pierre, Hélène; Licznar-Fajardo, Patricia; Hantova, Stefaniya; Godreuil, Sylvain; Martinez, Orianne; Jumas‐Bilak, Estelle

doi:10.1016/j.jgar.2018.06.022

Cited by 41 publications

(29 citation statements)

References 18 publications

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“…Besides, Enterobacter was con rmed to increase after both AMX administration and combine exposure of antibiotics, and the combination treatment caused its more substantial enrichment. Although these bacteria are considered commensal in the human gut, fecal carriage of this opportunistic pathogen con rmed to be a severe risk factor for the infection [77][78][79]. The signi cant increase in opportunistic pathogen associated with human disease-related pathways of human intestinal microbiota following combination of AMX and POL treatment exhibited in this study have not been reported in details yet.…”

Section: Combination Effects On the Genetic Level Attribute To Microbmentioning

confidence: 60%

Human gut microbiota evaluation and comparation after the separate or combined antibiotics exposure using the simulator of human intestinal microbial ecosystem (SHIME)

Liu¹,

Das²,

Suo³

et al. 2020

Preprint

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Background A cocktail of drugs is an emerging toxic contaminant that has potential public health risk worldwide, which also would cause human intestinal microbial disorder and develop multiple human diseases. However, to date, the combination effects of antibiotics cocktail on human intestinal microbiota dysbiosis and related health risk are not fully understood. Therefore, for the first time, this study evaluated and compared the in vitro ability of amoxicillin (AMX) and polymyxin E (POL) used separately or combined on antibiotic resistance genes (ARGs) as well as human disease-related pathways in the simulated human gut. Results This study indicated that the combination exposure of POL with AMX reduced the occurrence of drug resistance in the gut microbiota caused by single antibiotic treatment. However, in comparison with the separate use of AMX and POL, the combined treatment exhibited a significantly higher ability to increase the human disease-related pathways. The combination effects on genetic level might attribute to microbiota shift, as co-occurrence patterns suggested that Bifidobacterium attributed to ARGs increasing in the POL treatment group and Enterobacter played a crucial role in human disease-related pathways enrichment after combination treatment. Conclusion These results may open up new perspectives for assessing the direct effects of combination antibiotics on the intestinal microbiota. These suggested side-effects should be considered for a combination of antibiotics prescription.

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Section: Combination Effects On the Genetic Level Attribute To Microbmentioning

confidence: 60%

Human gut microbiota evaluation and comparation after the separate or combined antibiotics exposure using the simulator of human intestinal microbial ecosystem (SHIME)

Liu¹,

Das²,

Suo³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Riverine CRE often harbor several carbapenemase types [ 8 , 10 , 11 , 15 ]. A case of bla IMI-2 CP- Enterobacter asburiae bacteremia following a river near-drowning accident was described, and the infecting pathogen was isolated from the river one month later [ 16 ]. In two studies that reported the isolation of CPE from seawater, Enterobacter spp.…”

Section: Introductionmentioning

confidence: 99%

Multidrug-resistant enterobacteriaceae in coastal water: an emerging threat

Cohen

Paikin

Rokney

et al. 2020

Antimicrob Resist Infect Control

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Background The environmental role of carbapenemase-producing Enterobacteriaceae (CPE) acquisition and infection in human disease has been described but not thoroughly investigated. We aimed to assess the occurrence of CPE in nearshore aquatic bodies. Methods Enterobacteriaceae were cultured from coastal and estuary water near Netanya, Israel in June and July of 2018. Bacteria were identified by VITEK2® and their antimicrobial susceptibility was tested according to the CLSI guidelines. Enterobacteriaceae genomes were sequenced to elucidate their resistome and carbapenemase types. Results Among other clinically relevant bacteria, four CPE (three Enterobacter spp and one Escherichia coli isolate) were isolated from two river estuaries (Poleg and Alexander Rivers) and coastal water at a popular recreational beach (Beit Yanai). Molecular analysis and genome sequencing revealed the persistent presence of rare beta-lactamase resistance genes, including blaIMI-2 and a previously unknown blaIMI-20 allele, which were not found among the local epidemiological strains. Genome comparisons revealed the high identity of riverine and marine CPE that were cultivated one month apart. Conclusions We show that CPE contamination was widespread in nearshore marine and riverine habitats. The high genome-level similarity of riverine and marine CPEs, isolated one month apart, hints at the common source of infection. We discuss the clinical implications of these findings and stress the urgent need to assess the role of the aquatic environment in CPE epidemiology.

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“…Recent studies show that CRE may contaminate aquatic environments such as marine surface water(4-7), rivers (5,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), estuaries (18) and polluted drinking water (19). Riverine CRE often harbor several carbapenemase types [9,31] (8,10,11,15).…”

Section: Introductionmentioning

confidence: 99%

“…Riverine CRE often harbor several carbapenemase types [9,31] (8,10,11,15). A case of bla IMI-2 CP-Enterobacter asburiae bacteremia following a river near-drowning accident was described, and the infecting pathogen was isolated from the river one month later (16). In two studies that reported the isolation of CPE from seawater, Enterobacter spp.…”

Section: Introductionmentioning

confidence: 99%

“…Assessing the link between the clinical and aquatic epidemiology of CRE is often challenging. While some studies showed that clinical strains may be found in aquatic bodies (7,9,16), none such link was demonstrated in others (17,20). CRE may reach aquatic bodies as a result of organic contamination from multiple sources (21), including hospital e uents (22)(23)(24), wastewater treatment plants (WWTPs) (24)(25)(26), discharge of livestock farms and agriculture (3,27), seepage water(28) as well as others (21).…”

Section: Introductionmentioning

confidence: 99%

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Multidrug-Resistant Enterobacteriaceae in Coastal Water: An Emerging Threat

Cohen

Paikin

Rokney³

et al. 2020

Preprint

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Background: The environmental role of carbapenemase-producing Enterobacteriaceae (CPE) acquisition and infection in human disease has been described but not thoroughly investigated. We aimed to assess the occurrence of CPE in nearshore aquatic bodies.Methods: Enterobacteriaceae were cultured from coastal and estuary water near Netanya, Israel in June and July of 2018. Bacteria were identified by VITEK2® and their antimicrobial susceptibility was tested according to the CLSI guidelines. Enterobacteriaceae genomes were sequenced to elucidate their resistome and carbapenemase types. Results: Among other clinically relevant bacteria, four CPE (three Enterobacter spp and one Escherichia coli isolate) were isolated from two river estuaries (Poleg and Alexander Rivers) and coastal water at a popular recreational beach (Beit Yanai). Molecular analysis and genome sequencing revealed the persistent presence of rare beta-lactamase resistance genes, including blaIMI-2 and a previously unknown blaIMI-20 allele, which were not found among the local epidemiological strains. Genome comparisons revealed the high identity of riverine and marine CPE that were cultivated one month apart. Conclusions: We show that CPE contamination was widespread in nearshore marine and riverine habitats. The high genome-level similarity of riverine and marine CPEs, isolated one month apart, hints at the common source of infection We discuss the clinical implications of these findings and stress the urgent need to assess the role of the aquatic environment in CPE epidemiology.

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Transmission of IMI-2 carbapenemase-producing Enterobacteriaceae from river water to human

Cited by 41 publications

References 18 publications

Human gut microbiota evaluation and comparation after the separate or combined antibiotics exposure using the simulator of human intestinal microbial ecosystem (SHIME)

Human gut microbiota evaluation and comparation after the separate or combined antibiotics exposure using the simulator of human intestinal microbial ecosystem (SHIME)

Multidrug-resistant enterobacteriaceae in coastal water: an emerging threat

Multidrug-Resistant Enterobacteriaceae in Coastal Water: An Emerging Threat

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