Transmission of malaria tertiana by multi‐organ donation

Fischer, Lutz; Sterneck, Martina; Claus, Marc; Costard‐Jäckle, Angelika; Fleischer, Bernhard; Herbst, Hermann; Rogiers, Xavier; Broelsch, Christoph E.

doi:10.1034/j.1399-0012.1999.130609.x

Cited by 50 publications

(40 citation statements)

References 9 publications

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“…The prognosis of posttransplant malaria varies depending on a series of factors, including the type of organ transplanted, the species of Plasmodium involved, the type of immunosuppressive therapy, and, most importantly, the delay in diagnosis and initiation of treatment. In general, P. falciparum tends to be more virulent than other species (120,183,372). The parasites are capable of survival for more than 24 h in blood at 4°C, and therefore, the time of cold preservation does not prevent the transmission of the parasite.…”

Section: Routes Of Transmissionmentioning

confidence: 99%

“…Included in these data are the data from three publications that identified cases of malaria following multiorgan donation (81,120,245). In the cases reported by Fischer et al in 1999 following organ donation from an immigrant from an endemic zone (120), malaria due to P. vivax was detected in the liver recipient (28 days posttransplantation), heart recipient (suspected due to a rise in specific antibodies against P. vivax 12 months posttransplantation), and kidney recipient (6 weeks posttransplantation).…”

Section: Routes Of Transmissionmentioning

confidence: 99%

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Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Section: Routes Of Transmissionmentioning

confidence: 99%

Section: Routes Of Transmissionmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…A infecção de pacientes transplantados renais pode ser considerada rara por dois possíveis motivos: baixa divulgação em meio científico ou pelo fato dos grandes centros transplantadores não se localizarem em áreas endêmicas de malária. Assim, o objetivo deste trabalho foi relatar um caso de malária em paciente transplantado renal de longa data e suas peculiaridades 6,7,8 . Um paciente de 47 anos do gênero masculino, católico, pardo, minerador, natural de Mossoró (RN) e residente em Guarulhos (SP), portador de doença renal crônica (DRC) de etiologia indeterminada, hipertensão arterial sistêmica, transplantado renal de doador vivo há 13 anos e 10 meses, com creatinina estável em 1,1mg/dL.…”

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“…Assim, o transplantado pode se contaminar através da picada do inseto infectado (ciclo natural da doença) e pode evoluir mais gravemente pela maior replicação do parasita devido à terapia de imunossupressão a que está sujeito (terapia contra a rejeição do órgão transplantado) 7,8 . A doença pode, também, ser contraída pelo enxerto, quando este é extraído de doador infectado.…”

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Malária em paciente transplantado renal: uma nova ótica para um problema antigo – Relato de caso

Santos¹,

Gomes²,

Cardoso³

2018

R. Saúde

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ResumoA febre terçã ou malária é uma doença infecciosa endêmica da América Latina, África e Ásia e afetou em 2015 cerca de 212 milhões de pessoas, sendo que 459 mil pessoas foram a óbito. A malária é uma infecção considerada rara em transplantados renais e sua evolução é pouco descrita na literatura. O objetivo deste trabalho foi relatar esta doença em paciente transplantado renal de longa data e suas peculiaridades. Este paciente transplantado renal contraiu malária em fevereiro de 2017 em um garimpo de ouro na Guiana Francesa e foi tratando com Artesunato. Em março de 2017, após tratamento, retornou com sinais e sintomas e com comprovação de infecção por Plasmodium vivax através de exame laboratorial de gota espessa. Na sequência, o paciente foi tratado com cloroquina (3 dias) e primaquina (18 dias) com boa evolução clínica. Malária em paciente transplantado renal: Uma nova ótica para um problema antigo -Relato de caso Palavras AbstractThe third fever or malaria is an infectious disease endemic in Latin America, Africa and Asia and affected in 2015 about 212 million and 459 thousand people died. The objective of this study was to report malaria in a long-term renal transplant patient and its peculiarities. Renal transplant patient contracted malaria in February 2017 in gold panning in French Guiana, dealing with Artesunato. In March 2017 even after treatment returned with signs and symptoms, with evidence of infection by Plasmodium vivax through laboratory examination of thick gout was treated with good clinical evolution. Malaria infection in renal transplant patients is considered rare and its evolution is poorly understood by the scientific community.

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“…Recently, transmission of malaria tertiana from an organ donor to a liver recipient was reported in Germany. 117 The donor recently had migrated from Africa to Germany with no signs of active malaria. The liver and one renal recipient developed positive blood smears for Plasmodium vivax 5 to 6 weeks after transplantation.…”

Section: Malariamentioning

confidence: 99%

Impact of donor infections on outcome of orthotopic liver transplantation

Angelis

Cooper

Freeman

2003

Liver Transplantation

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Infection occurs when microbial agents enter the host, either through airborne transmission or by direct contact of a substance carrying the infectious agent with the host. Human body fluids, solid organs, or other tissues often are ideal vectors to support microbial agents and can transmit infections efficiently from donor to recipient. In the case of blood transfusion and tissue transplantation, the main consequence of such a transmission is infection of the recipient. However, in the case of solid-organ transplantation, and particularly for liver transplantation, donor infections are not only transmitted to the recipient, the donor infection also may affect the donated liver's preservability and subsequent function in the recipient irrespective of the systemic consequences of the infection. In addition, solid organ recipients of infected organs are less able to respond to the infectious agent because of their immunosuppressive treatment. Thus, transmission of infections from organ donor to liver recipient represents serious potential risks that must be weighed against a candidate's mortality risk without the transplant. However, the ever-increasing gap between the number of donors and those waiting for liver grafts makes consideration of every potential donor, regardless of the infection status, essential to minimize waiting list mortality. In this review, we will focus on assessing the risk of transmission of bacterial, fungal, viral, and parasitic infectious agents from cadaveric liver donors to recipients and the effect such a transmission has on liver function, morbidity, and mortality. We will also discuss risk-benefit deliberations for using organs from infected donors for certain types of recipients. These issues are critically important to maximize the use of donated organs but also minimize recipient morbidity and graft dysfunction. (Liver Transpl 2003; 9:451-462.)

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Transmission of malaria tertiana by multi‐organ donation

Cited by 50 publications

References 9 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Malária em paciente transplantado renal: uma nova ótica para um problema antigo – Relato de caso

Impact of donor infections on outcome of orthotopic liver transplantation

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