Transmission of whole body vibration – Comparison of three vibration platforms in healthy subjects

Spain, Lucy; Yang, Lang; Wilkinson, JM; McCloskey, Eugène

doi:10.1016/j.bone.2020.115802

Cited by 9 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characteristics of each of the aforementioned interventions to produce PSS, are summarized in Table 1. Frequency Range (Hz) 2.7-3.0 (Kawabata et al, 2013;Clermont et al, 2019) 1-1.7 (Raza et al, 2017;Lin et al, 2020) 12-60 (Sonza et al, 2015;Rawer, 2020;Spain et al, 2020) 1.7-3.0 (Kohler et al, 2007;Rokutanda et al, 2011) 1.7-3.0 (Sackner et al, 2019(Sackner et al, , 2020 Root Mean Square Acceleration (a RMS ) (m/s 2 1.5-2.5 N/A 2.1-7.0 dependent on amplitude, f, and location of measurement (Sonza et al, 2015) 2.0-3.5 1.0-3.0…”

Section: The Effects Of Wbpa and Jd On Diabetesmentioning

confidence: 99%

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

et al. 2021

View full text Add to dashboard Cite

Diabetes has reached worldwide epidemic proportions, and threatens to be a significant economic burden to both patients and healthcare systems, and an important driver of cardiovascular mortality and morbidity. Improvement in lifestyle interventions (which includes increase in physical activity via exercise) can reduce diabetes and cardiovascular disease mortality and morbidity. Encouraging a population to increase physical activity and exercise is not a simple feat particularly in individuals with co-morbidities (obesity, heart disease, stroke, peripheral vascular disease, and those with cognitive and physical limitations). Translation of the physiological benefits of exercise within that vulnerable population would be an important step for improving physical activity goals and a stopgap measure to exercise. In large part many of the beneficial effects of exercise are due to the introduction of pulsatile shear stress (PSS) to the vascular endothelium. PSS is a well-known stimulus for endothelial homeostasis, and induction of a myriad of pathways which include vasoreactivity, paracrine/endocrine function, fibrinolysis, inflammation, barrier function, and vessel growth and formation. The endothelial cell mediates the balance between vasoconstriction and relaxation via the major vasodilator endothelial derived nitric oxide (eNO). eNO is critical for vasorelaxation, increasing blood flow, and an important signaling molecule that downregulates the inflammatory cascade. A salient feature of diabetes, is endothelial dysfunction which is characterized by a reduction of the bioavailability of vasodilators, particularly nitric oxide (NO). Cellular derangements in diabetes are also related to dysregulation in Ca2+ handling with increased intracellular Ca2+overload, and oxidative stress. PSS increases eNO bioavailability, reduces inflammatory phenotype, decreases intracellular Ca2+ overload, and increases antioxidant capacity. This narrative review and perspective will outline four methods to non-invasively increase PSS; Exercise (the prototype for increasing PSS), Enhanced External Counterpulsation (EECP), Whole Body Vibration (WBV), Passive Simulated Jogging and its predicate device Whole Body Periodic Acceleration, and will discuss current knowledge on their use in diabetes.

show abstract

Section: The Effects Of Wbpa and Jd On Diabetesmentioning

confidence: 99%

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Compared to vertical vibration transmission, side alternating vibrations lead to higher neuromuscular activity [ 43 , 44 ], heart rate response and oxygen consumption [ 19 ]. Despite using similar input vibration characteristics, side-alternating WBV also produced greater acceleration magnitudes through the lower body [ 45 – 47 ]. If an increase in physiological response contributes to improved cognitive performance, side-alternating vs. vertical WBV might be more effective.…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of side-alternating Whole-Body Vibration on cognitive function of young adults

et al. 2023

View full text Add to dashboard Cite

Recent research in rodents and humans revealed that Whole-Body Vibration (WBV) is beneficial for cognitive functions. However, the optimal WBV conditions are not established: contrary to vertical WBV, side-alternating WBV was not investigated before. The present study investigated the short-term effects of side-alternating WBV in standing and sitting posture on specific cognitive function of young adults. We used a balanced cross-over design. Sixty healthy young adults (mean age 21.7 ± 2.0 years, 72% female) participated. They were exposed to three bouts of two-minute side-alternating WBV (frequency 27 Hz) and three control conditions in two different sessions. In one session a sitting posture was used and in the other session a standing (semi-squat) posture. After each condition selective attention and inhibition was measured with the incongruent condition of the Stroop Color-Word Interference Test. WBV significantly (p = 0.026) improved selective attention and inhibition in the sitting posture, but not in the standing posture. The sitting posture was perceived as more comfortable, joyous and less exhaustive as compared to the standing posture. This study demonstrated that side-alternating WBV in sitting posture improves selective attention and inhibition in healthy young adults. This indicates that posture moderates the cognitive effect of WBV, although the effects are still small. Future studies should focus on the working mechanisms and further optimization of settings, especially in individuals who are unable to perform active exercise.

show abstract

A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.

Fernandez‐Yague,

Palma,

Tofail

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Preserving the function of human tendon‐derived cells (hTDCs) during cell expansion is a significant challenge in regenerative medicine. In this study, a non‐genetic approach is introduced to control the differentiation of hTDCs using a newly developed tympanic bioreactor. The system mimics the functionality of the human tympanic membrane, employing a piezoelectrically tuned acoustic diaphragm made of polyvinylidene fluoride‐co‐trifluoroethylene and boron nitride nanotubes. The diaphragm is vibrationally actuated to deliver targeted electromechanical stimulation to hTDCs. The results demonstrate that the system effectively maintains the tendon‐specific phenotype of hTDCs, even under conditions that typically induce nonspecific differentiation, such as osteogenesis. This stabilization is achieved by modulating integrin‐mediated mechanosignaling via ion channel‐regulated calcium activity, potentially by TREK‐1 and PIEZO1, yet targeted studies are required for confirmation. Finally, the system sustains the activation of key differentiation pathways (bone morphogenetic protein, BMP) while downregulating osteogenesis‐associated (mitogen‐ctivated protein kinase, MAPK and wingless integrated, WNT) pathways and upregulating Focal Adhesion Kinase (FAK) signaling. This approach offers a finely tunable, dose‐dependent control over hTDC differentiation, presenting significant potential for non‐genetic approaches in cell therapy, tendon tissue engineering, and the regeneration of other mechanosensitive tissues.

show abstract

Transmission of whole body vibration – Comparison of three vibration platforms in healthy subjects

Cited by 9 publications

References 36 publications

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

Short-term effects of side-alternating Whole-Body Vibration on cognitive function of young adults

A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.

Contact Info

Product

Resources

About