Transmission risk of two chikungunya lineages by invasive mosquito vectors from Florida and the Dominican Republic

Alto, Barry W.; Wiggins, Keenan; Eastmond, Bradley; Vélez, Daniel Alberto Ospina; Lounibos, L. Phillip; Lord, Cynthia C.

doi:10.1371/journal.pntd.0005724

Cited by 54 publications

(80 citation statements)

References 59 publications

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“…aegypti [126,127,144,161–164,164–166], Ae. albopictus [127,144,162,164–167], Aedes terrens [168], and Haemagogus leucocelaenus [168] are all experimentally competent to transmit chikungunya virus. Chikungunya virus transmission in Ae.…”

Section: Resultsmentioning

confidence: 99%

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Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Jones

Kulkarni

Davidson

et al. 2019

Preprint

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27 Background 28 Three arthorpod-borne viruses (arboviruses) causing human disease have been the focus 29 of a large number of studies in the Americas since 2013 due to their global spread and 30 epidemiological impacts: Zika, dengue, and chikungunya viruses. A large proportion of 31 infections by these viruses are asymptomatic. However, all three viruses are associated with 32 moderate to severe health consequences in a small proportion of cases. Two mosquito species, 33 Aedes aegypti and Aedes albopictus, are among the world's most prominent arboviral vectors, 34 and are known primary vectors for all three viruses in the Americas. 35 Objectives 2 36 This review summarizes the state of the entomological literature surrounding the biology 37 and ecology of vectors of Zika, dengue and chikungunya viruses and factors affecting virus 38 transmission. The rationale of the review was to elucidate consensus and discord between 39 studies, and guide future research based on identified knowledge gaps. 40 Results 41 A total of 196 studies were included in the scoping review after initial screening and 42 subsequent exclusion of out-of-scope studies, secondary data publications, duplicate records, and 43 studies unavailable in English language. 44 Key findings 45 Temperature and humidity have the strongest impact on mosquito distribution and 46 dynamics, development of immatures and arborviral infection rates. Low socioeconomic status 47 and related factors, including poor infrastructure, inconsistent access to water, and high 48 household resident density, have been consistently associated with arbovirus vector occurrence. 49 Effects of interspecific competition on arboviral vector species is currently poorly understood. 50 Vector competence for Zika virus is well established for Ae. aegypti and Ae. albopictus. 51 Information on Zika virus vector transmission dynamics is sparse in contrast to the wealth of 52 research available for dengue and chikungunya viruses. 53 Conclusions 54Based on the internationally recognized urgency of Zika virus infection as a public health 55 concern, further research on arbovirus vectors and transmission dynamics is of pressing need. 56 57

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Section: Resultsmentioning

confidence: 99%

“…aegypti with Zika, chikungunya and dengue viruses minimally affected vector competence, and that vectors were able to transmit each viral pair, as well as three viruses simultaneously. Alto et al [167] found Ae. aegypti and Ae.…”

Section: Resultsmentioning

confidence: 99%

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Jones

Kulkarni

Davidson

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

Section: Virus Transmission Dynamicsmentioning

confidence: 98%

“…aegypti [46,[63][64][65][66][67][68], Ae. albopictus [46,64,[66][67][68][69], Aedes terrens [70], and Haemagogus leucocelaenus [70] are all experimentally competent to transmit chikungunya virus. Chikungunya virus transmission in Ae.…”

Section: Vector Species Compositionmentioning

confidence: 99%

Arbovirus vectors of epidemiological concern in the Americas: A scoping review of entomological studies on Zika, dengue and chikungunya virus vectors

et al. 2020

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Background Three arthropod-borne viruses (arboviruses) causing human disease have been the focus of a large number of studies in the Americas since 2013 due to their global spread and epidemiological impacts: Zika, dengue, and chikungunya viruses. A large proportion of infections by these viruses are asymptomatic. However, all three viruses are associated with moderate to severe health consequences in a small proportion of cases. Two mosquito species, Aedes aegypti and Aedes albopictus, are among the world's most prominent arboviral vectors, and are known vectors for all three viruses in the Americas. Objectives This review summarizes the state of the entomological literature surrounding the mosquito vectors of Zika, dengue and chikungunya viruses and factors affecting virus transmission. The rationale of the review was to identify and characterize entomological studies that have been conducted in the Americas since the introduction of chikungunya virus in 2013, encompassing a period of arbovirus co-circulation, and guide future research based on identified knowledge gaps. Methods The preliminary search for this review was conducted on PubMed (National Library of Health, Bethesda, MD, United States). The search included the terms 'zika' OR 'dengue'

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“…luteocephalus, Ae. neoafricanus have been revealed as vectors in sylvatic cycle, though, mainly in Africa [7,8]. Moreover, Culex species as a transmission vector for CHIKV in humans and birds has been mainly reported in Italy, France, Zimbabwe, Philippines and South Africa [9].…”

Section: Introductionmentioning

confidence: 99%

Antiviral therapeutics for chikungunya virus

Ghildiyal

Gabrani

2020

Expert Opinion on Therapeutic Patents

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Introduction: Chikungunya virus (CHIKV), a reemerging human arthropod borne virus, can causes global epidemic outbreaks and has become a serious health concern due to the unavailability of any antiviral therapy/vaccine. Extensive research has been conducted to target different proteins from CHIKV to curtail the spread of virus. Areas covered: This review provides an overview of the granted patents including the current status of antiviral strategies targeting CHIKV. Expert opinion: Under the current scenario, potential molecules and different approaches have been utilized to suppress CHIKV infection. MV-CHIKV and VRC-CHKVLP059-00-VP vaccine candidates have successfully completed phase I clinical trials and ribavirin (inhibitor) has shown significant inhibition of CHIKV replication and could be the most promising candidates. The drug resistance and toxicity can be modulated by using the inhibitors/drugs in combination. Moreover, nanoparticle formulations can improve the efficacy and bioavailability of drugs.

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Transmission risk of two chikungunya lineages by invasive mosquito vectors from Florida and the Dominican Republic

Cited by 54 publications

References 59 publications

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Arbovirus vectors of epidemiological concern in the Americas: A scoping review of entomological studies on Zika, dengue and chikungunya virus vectors

Antiviral therapeutics for chikungunya virus

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