Transoral gastroplasty is safe, feasible, and induces significant weight loss in morbidly obese patients: results of the second human pilot study

Abstract

This second pilot trial confirmed the feasibility and safety of transoral gastroplasty. The early results and technical improvements reported in the present study are encouraging in terms of safety, early weight loss, and quality of life, and clearly allowed multicenter trials, which are planned to start soon.

Initial Experience with New Intraluminal Devices for GERD Barrett’s Esophagus and Obesity

“…Deviere and Moreno have published pilot human studies using a transoral device to create a vertical gastroplasty. 10,11 The device named transoral gastroplasty (Satiety, Palo Alto, CA) contains a stapler body with two jaws and a septum with retraction wire to orient the stomach tissue for capture and stapling. Suction pulls tissue from the anterior and posterior walls of the stomach into the device and the stapler is closed and fired.…”

“…Investigations of intraluminal restrictive techniques for obesity are ongoing but durability of effect is in question. 10,11 Numerous mucosal ablation and excision methods for Barrett's esophagus have been devised; ablation techniques include photodynamic therapy, ultrasonic ablation, Argon beam coagulation, radiofrequency ablation, cryotherapy ablation, and bipolar electrocoagulation. [12][13][14][15] The primary excision technique is endoscopic mucosal resection (EMR) which is limited by cautery margins, specimen disorientation, and small size.…”

Endoscopic Approaches to Obesity

“…Moreno et al [20] reported more encouraging results in the second human pilot study due to those technical improvements of the procedure. Eleven patients (mean BMI 41.6 ± 4.3, range 37–53) were enrolled in this study.…”

Veille technologique sur les traitements endoscopiques de l’obésité en 2009–2010

“…La perte d'excès pondéral (PEP) était de 24,4 % à six mois chez des patients dont l'IMC moyen était de 43,3 avant la procédure [15]. Il est possible de modifier la poche après trois mois en cas de perte de poids insuffisante, en rajoutant des agrafes [16].…”