Transplacental and milk transfer of polybrominated biphenyls to perinatal guinea pigs from treated dams

Ecobichon, D. J.; Hidvegi, S.; Comeau, Anne Marie; Cameron, Pamela H.

doi:10.1016/0300-483x(83)90105-1

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…The particular congeners followed were chosen because they were convenient representatives (34.5% by weight) of those present in Fenclor 64, further they are known to accumulate in adipose tissue and are frequently found in animal and human milk or fat samples (Vodicnik et al 1980a, Mes 1988McFarland & Clarke 1989). After a single dose of Fenclor 64 administered during pregnancy these PCBs passed across the placenta and into foetal tissues as also observed in other animal species (Ecobichon et al 1983, Jacobson et al 1984Ring et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Elimination of PCB Congeners via Milk in Rabbits Administered Fenclor 64

Montesissa¹,

Lauro²,

Fadini³

et al. 1992

Pharmacology & Toxicology

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A single dose of 100 mg per kg body weight of a commercial mixture of polychlorinated biphenyls (PCB), Fenclor 64 was given intraperitoneally to pregnant rabbits. The distribution in dams and foetuses and excretion in milk was investigated for six of the congeners by quantifying them in fat from maternal adipose tissue, from whole foetuses and newborn bodies and from newborn gastric contents. The cytochrome-P-450 induction after Fenclor 64 in foetuses and suckling off-spring was followed by measuring the following hepatic mixed function oxidase (MFO) activities: p-nitroanisole-demethylase, ethoxyresorufin-deethylase, ethoxycoumarin-deethylase and NADPH cytochrome-C reductase. At the 28th day of pregnancy PCB fat concentrations in foetuses were similar to those in mothers (126.4 +/- 7.1 and 152.6 +/- 28.1 micrograms/g of fat, respectively). By the 5th day of life fat concentrations in the youngs were double those of foetuses (216.81 +/- 8.12 micrograms/g) and remained high until weaning (142.2 +/- 15.5 micrograms/g at the 20th day). PCB concentrations in mothers' fat decreased during lactation (104.1 micrograms/g at the 20th day) but at the end of the experiment they were still high (95.5 micrograms/g). The cytochrome-P-450 concentration and MFO activities in young rabbits' livers from treated dams were significantly higher than controls from the 5th (P less than 0.01) to the 10th (P less than 0.01) day of life, with the exception of NADPH-cyt-C-reductase (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Elimination of PCB Congeners via Milk in Rabbits Administered Fenclor 64

Montesissa¹,

Lauro²,

Fadini³

et al. 1992

Pharmacology & Toxicology

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“…46,47 A meia-vida desses compostos nos organismos é bastante variável, por exemplo, 22 dias em porquinhos--da-índia a 4 anos em macacos. 48,49 Em humanos, pode variar de 8 a 30 anos. 43 Esses tempos vão depender da idade, massa corpórea, gestação, histórico de vida, etc.…”

Section: Bifenilas Polibromadas (Pbbs)unclassified

Retardantes de chama bromados: uma revisão

Pieroni¹,

Leonel²,

Fillmann³

2016

Quim. Nova

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“…Guinea pigs of approximately 65 days gestation received a single oral dose of Firemaster FF-1 (50 mg/kg b.w.) (Ecobichon et al, 1983). The pregnant animals and their fetuses were killed 2 days later, at term.…”

Section: Distributionmentioning

confidence: 99%

Scientific Opinion on Polybrominated Biphenyls (PBBs) in Food

2010

EFSA Journal

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EFSA was asked by the European Commission to deliver a scientific opinion on polybrominated biphenyls (PBBs) in food. PBBs are additive flame retardants which were applied in synthetic fibres and polymers. PBBs are present in the environment at low concentrations and likewise in biota and in food and feed. Data from the analysis of 16 PBB congeners in 794 food samples were provided to EFSA by 6 Member States, covering the period from 2003 to 2009. Toxicity studies were carried out with technical PBB mixtures of which the exact congener composition is not known. Main targets were the liver, thyroid hormone homeostasis and the reproductive, nervous and immune systems. PBBs are not directly genotoxic. The Panel on Contaminants in the Food Chain (CONTAM Panel) selected the hepatic carcinogenic effects as the critical effect, with a no‐observed‐effect level (NOEL) of 0.15 mg/kg body weight (b.w.). Since this NOEL was obtained in a study with a technical PBB mixture, the congener profile of which differs from that currently found in food, the CONTAM Panel concluded that it was inappropriate to use this NOEL to derive a health based guidance value. The intake of PBBs by high and frequent consumers of fatty fish, the subgroup with the highest dietary exposure, was approximately 6 orders of magnitude less than this NOEL. Exposure for high consuming breast‐fed infants is 5 orders of magnitude less than this NOEL. Therefore the CONTAM Panel concluded that the risk to the European population from exposure to PBBs through the diet is of no concern. Since PBBs are no longer produced or used in Europe and taking into account low and declining environmental concentrations, the CONTAM Panel concluded that PBBs are a low priority for further research or monitoring efforts.

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Transplacental and milk transfer of polybrominated biphenyls to perinatal guinea pigs from treated dams

Cited by 5 publications

References 31 publications

Elimination of PCB Congeners via Milk in Rabbits Administered Fenclor 64

Elimination of PCB Congeners via Milk in Rabbits Administered Fenclor 64

Retardantes de chama bromados: uma revisão

Scientific Opinion on Polybrominated Biphenyls (PBBs) in Food

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