Transplacental transport of IgG antibodies to preterm infants: A review of the literature

Berg, Jolice P. van den; Westerbeek, Elisabeth A. M.; Klis, Fiona R.M. van der; Berbers, Guy A. M.; Elburg, Ruurd M. van

doi:10.1016/j.earlhumdev.2010.11.003

Cited by 175 publications

(117 citation statements)

References 45 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…1 This is likely due to a shortened period for maternal immunologic response and transfer of antibody to the fetus. 8 After primary immunization, antibodies to PT (37.2 vs 28.8), FHA (23.0 vs 25.5), and Fim (119 vs 114) were generally comparable between premature and term infants born to vaccinated mothers, but lower than in the sera of the infants of unvaccinated mothers. 1 Given that the UK schedule does not include any further pertussis immunization until children are 3 years old, it is reassuring that the observed differences between the groups had resolved by 12 months of age, a finding also previously reported in term infants.…”

Section: Discussionmentioning

confidence: 90%

“…[3][4][5] Premature infants have an increased risk of pertussis infection and are more likely to develop severe illness, resulting in prolonged hospitalization, intensive care admission, and death. 6,7 At the same time, because transplacental transfer of maternal antibodies to the fetus occurs predominantly in the last trimester of pregnancy, 8 premature infants may not benefit from maternal vaccination to the same extent as their term-born peers.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy

et al. 2016

View full text Add to dashboard Cite

on behalf of the PUNS study group abstract BACKGROUND AND OBJECTIVES: Maternal antenatal pertussis-containing vaccination is recommended for the prevention of neonatal pertussis, but the ability of maternal vaccination to protect premature infants is unknown. We hypothesized that that infants born prematurely to antenatally vaccinated women would have higher pertussis antibody concentrations than those born to unvaccinated women.

show abstract

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Yet total IgG level is markedly lower in neonates (cord blood) than in adults (28). Furthermore, differences in transport kinetics between the IgG subclasses may cause qualitative differences in titers of IgG subclasses (29,30), e.g., IgG1, IgG3, and IgG4 are fairly efficiently transported across the placenta, whereas transport of IgG2 is less efficient (30). It has previously been reported that preterm neonates have considerably lower titers of anticoagulase-negative staphylococci IgG antibodies and antibody-mediated opsonic activity against coagulase-negative staphylococci as compared with adults (31,32).…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults

et al. 2012

View full text Add to dashboard Cite

Background: Staphylococcus epidermidis (se) is an important cause of late-onset sepsis in neonates. se frequently produces a polysaccharide intercellular adhesin (PIa) biofilm, important in the pathogenesis of these infections. Little is known about how the neonatal innate immune system reacts to se biofilm-associated infections. Our hypothesis was that se biofilms induce a lower complement activation in neonates as compared with adults. Methods: cord blood from term infants (n = 15) and blood from adults (n = 6) were studied in an ex vivo whole-blood sepsis model. a PIa biofilm-producing strain (se1457) and its isogenic mutant (M10), producing a non-PIa biofilm, were used. results: Both se biofilms induced stronger complement activation in adult than in cord blood (P ≤ 0.033). We found lower levels of antibodies toward both PIa (P = 0.002) and the whole bacterium (P = 0.001) in cord vs. adult blood. By contrast, the interleukin-8 (IL-8) and IL-6 secretion were higher in cord than in adult blood (P ≤ 0.002). The PIa biofilm induced stronger complement activation than the non-PIa biofilm. conclusion: We conclude that the neonatal complement system exhibits a maturational deficiency. This may reduce the ability of neonates to combat biofilm-associated se infections. Staphylococcus epidermidis (SE) is the most prevalent pathogen causing late-onset sepsis in neonates (1). These infections are seldom lethal, but they cause significant morbidity, especially in preterm infants (1,2). SE infections are often associated with biofilm production on the surface of foreignbody implants (3,4). Biofilms are adherent multicellular bacterial aggregates embedded in a self-produced extracellular matrix. The best-described matrix compound in SE biofilms is a β-(1,6)-linked N-acetylglucosamine named polysaccharide intercellular adhesin (PIA) (5,6).SE and SE biofilms interfere with the host immune response at different levels. PIA biofilms inhibit the action of antimicrobial peptides (7), decrease neonatal inflammatory response (8), and decrease phagocytosis and degranulation by neutrophils (7). Biofilms may "decoy" antibodies and complement on the bacterial surface and thereby decrease opsonization and phagocytosis (9-11). The ability of biofilm-producing bacteria to avoid immune clearance and the general immaturity of the neonatal immune system (12) are postulated to increase the risk of neonatal SE sepsis (13). As compared with adults, neonates have a lower quantitative and qualitative complement activation (14,15), reduced upregulation of cellular response (12), and an immature cytokine response pattern (16)(17)(18)(19). Preterm infants demonstrate a markedly reduced capacity to upregulate oxidative burst in leukocytes in response to SE (20). However, some authors have reported that SE may induce a similar proinflammatory cytokine response in neonates and adults (19,21), indicating a differential maturation of various parts of the neonatal innate immune system. Differences in maturation have also been described when challenging t...

show abstract

“…Features of immaturity of innate immunity following preterm birth including a smaller pool of effector cells (neutrophils, monocytes, natural killer cells and antigen presenting cells) and lower levels of inflammatory cytokines have been reported by several studies [18,21,22]. In addition, the levels of antigen specific immunoglobulins are substantially reduced in preterm infants, since these antibodies are largely transferred across the placenta during the third trimester, particularly after the 32nd week of gestation [23]. Preterm birth is also associated with limited production and function of antimicrobial proteins, peptidases and soluble cytokines [22,24,25].…”

Section: Preterm Birth and Bronchopulmonary Dysplasia: An Immature Symentioning

confidence: 95%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

View full text Add to dashboard Cite

Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

show abstract

Transplacental transport of IgG antibodies to preterm infants: A review of the literature

Cited by 175 publications

References 45 publications

Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy

Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy

Staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults

The impact of respiratory viruses on lung health after preterm birth

Contact Info

Product

Resources

About