The combined ethics committee of the Organ Procurement and Transplantation Network (OPTN) and the United Network for Organ Sharing (UNOS) issued a 2015 white paper explaining the ethical principles that should guide allocation of human organs. The white paper does not mention procurement of organs, other than to say that selling organs is prohibited. Must procurement of organs also adhere to certain ethical principles? If so, which principles and why? In view of your argument, is use of social media to solicit organ donation ethical? Response The need for more organ donation in the United States is an ongoing struggle for the transplant community. According to the US Department of Health and Human Services (HHS), approximately 22 people die daily awaiting an organ transplant [1]. As of October 2015, an estimated total of 122,440 people nationwide were on organ waiting lists, a roughly fivefold increase from 1991 [1]. Unfortunately, the number of organ transplants performed in 2014 remained stagnant at around 29,532, which is less than a twofold increase over a 23-year period [1]. Recent social media campaigns, described below, have focused on increasing online organ registry enrollment rates, an alternative to registering citizens through states' driver's licensure processes. The United States currently uses an "opt-in" system for organ donation, requiring "concrete action" from citizens to declare their intentions to donate [2]. An alternative option in the US is "mandated choice"; for example, in 2006, Illinois passed a first-person consent law, according to which citizens are required to indicate legally binding organ donation preferences when registering or renewing their driver's licenses [2]. In contrast, some European countries such as Spain, Belgium, and Austria use an "opt-out" system [2] in which consent to donate is presumed [3]. This presumed consent model generally applies to all organs; a model is termed "soft" if family views are taken into account or "hard" if only the patient's wishes are honored [3]. A 2006 study that followed the organ donation rates of 22 "presumed consent" countries over a 10-year period found that, after correcting for other determinants impacting donation, "cadaveric donation rates [were] 25-30% higher on average in presumed consent countries" [4]. This study suggests that increased organ donation rates are due to legislative changes, but the