Transplantable Myeloid Rat Leukaemia Induced by 7,12-Dimethylbenz(a)anthracene

F, Gál; Somfai, S; Szentirmay, Zoltán

doi:10.1159/000208415

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…This myeloid nature showed similarities with both human CML (as demonstrated by high peroxidase and Sudan black B positive cells and reduction in alkaline phosphatase positivity) and human AML (non-specific esterase activity, highly reduced in the peripheral blood but slightly reduced in BM). These findings do not support the use of these rats as an exclusive AML model [68].…”

Section: Rodent Modelsmentioning

confidence: 86%

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology

Skayneh

Jishi

Hleihel

et al. 2019

Genes

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Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous hematological malignancies. AML prognosis largely depends on acquired cytogenetic, epigenetic, and molecular abnormalities. Despite the improvement in understanding the biology of AML, survival rates remain quite low. Animal models offer a valuable tool to recapitulate different AML subtypes, and to assess the potential role of novel and known mutations in disease progression. This review provides a comprehensive and critical overview of select available AML animal models. These include the non-mammalian Zebrafish and Drosophila models as well as the mammalian rodent systems, comprising rats and mice. The suitability of each animal model, its contribution to the advancement of knowledge in AML pathophysiology and treatment, as well as its advantages and limitations are discussed. Despite some limitations, animal models represent a powerful approach to assess toxicity, and permit the design of new therapeutic strategies.

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Section: Rodent Modelsmentioning

confidence: 86%

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology

Skayneh

Jishi

Hleihel

et al. 2019

Genes

View full text Add to dashboard Cite

show abstract

“…Furthermore, experimental models recapitulating AML uncovered much about the molecular pathophysiology (11,12) and the therapeutic approaches of the disease (13)(14)(15). Considering the largely comparable myeloid features of subcutaneously transplanted Wistar/Furth (W/Fu) AML ( 16) or 7, 12dimethylbenz(a)anthracene (DMBA)-generated acute rat leukemia (17) to those of the human disease, AML models could also be applicable for the evaluation of anti-tumor drug candidates prior to clinical usage.…”

mentioning

confidence: 99%