Transplantation of adipose stromal cells, but not mature adipocytes, augments ischemia-induced angiogenesis

Mesenchymal stem cells in mammary adipose tissue stimulate progression of breast cancer resembling the basal-type

“…show that expression of VEGF-A, but not bFGF, by bMSCs is necessary for chemoattracting endothelial cells. Our observation that bMSCs assemble into vessel-like structures within Matrigel in vitro and in vivo, suggest that perhaps bMSC promote tumor vascularity by a second (and not necessarily mutually exclusive) mechanism: rather than recruiting endothelial cells to the tumor microenvironment, they incorporate into vessels within the tumor by directly differentiating into endothelial cells, as previously reported for adipose MSCs in an ischemic injury model [34][35][36] and the 4T1 murine model of breast cancer progression. 23 Despite our in vitro data favoring the potential involvement of bMSCs in promoting breast cancer vascularity, we did not observe a significant difference in capillary density either within or around the tumor when comparing T4-2 vs. T4-2/bMSC xenografts at two (fat pad and subcutaneous) inoculation sites.…”

Angiogenesis and development of adipose tissue

“…progenitor cell supply and growth factor release) suggests that autologous subcutaneous adipose tissue may be a next generation candidate as cell source for therapeutic angiogenesis. Murine, as well as human adipose tissue-derived stromal cells, augmented new vessel formation when transplanted into the ischemic hind limb in mice, confirming the potential therapeutic value (Rehman et al, 2004;Sumi et al, 2007).…”

Transplantation of Adipose Stromal Cells Promotes Neovascularization of Random Skin Flaps

“…Large quantity of SVF will surely play same roles as homogeneous ADSCs and could be used as a better option for implantation. A positive role of SVF has been verified in ischemic hindlimb study (Sumi et al 2007). However, its therapeutic effect on flap ischemia has remained unclear.…”

“…These cells could differentiate into endothelial cells and, when palced in methylcellulose, were capable of forming capillary-like structures producing a high level of VEGF (De Francesco et al 2009). Sumi et al (Sumi et al 2007) transplanted SVF of C57BL/6 mice into ischemic hindlimb, and discovered that SVF significantly augmented collateral development as determined by the restoration of blood perfusion and capillary density of the ischemic muscle. Based on the positive findings in previous studies, SVF may be a better choice for the clinical treatment of ischemia therapy.…”