Transplantation of Bone Marrow Cells Reduces Ccl4–Induced Liver Fibrosis in Mice

Sakaida, Isao; Terai, Shuji; Yamamoto, Naoki; Aoyama, Koji; Ishikawa, Tsuyoshi; Nishina, Hiroshi; Okita, Kiwamu

doi:10.1002/hep.20452

Cited by 500 publications

(466 citation statements)

References 29 publications

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“…The incidence of plasticity has been shown to be very variable, from extremely rare to a range from 20% to 40% [12,13] . Although there is still controversy about which part of bone marrow cells can differentiate into hepatocytes, the present study clearly shows that transplanted bone marrow cells may help restore the hepatic degenerative diseases and reduce CCl4-induced liver fibrosis [14] . Some studies readily demonstrated bone marrow stromal cells (BMSCs) differentiated into hepatocyte-like cells in culture after HGF treatment in vitro [15] .…”

Section: Introductionmentioning

confidence: 50%

“…However, other data demonstrate that bone marrow-derived hepatocyte is only a possible but rare event, even in the presence of very strong selection pressure [23] . Several reports have demonstrated that cell fusion is the principal source of bone marrow-derived hepatocytes [24] , and bone marrow-derived hepatocytes are primarily of mature myelomonocytic cells which fuse spontaneously with host hepatocytes producing functional liver repopulation [14] .…”

Section: Discussionmentioning

confidence: 99%

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Transplanted bone marrow stromal cells are not cellular origin of hepatocellular carcinomas in a mouse model of carcinogenesis

Zheng¹,

Liu²

2008

WJG

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AIM:To investigate the malignant potential of hepatic stem cells derived from the bone marrow stromal cells (BMSCs) in a mouse model of chemical hepatocarcinogenesis. METHODS:BMSCs from male BALB/c mice were harvested and cultured, then transplanted into female syngenic BALB/ c mice via portal vein. Hepato-carcinogenesis was induced by 6 mo of treatment with diethylnitrosamine (DEN). Six months later, the liver was removed from each treated mouse and evaluated by immunohistochemistry and fluorescence in situ hybridization (FISH). RESULTS:Twenty-six percent of recipient mice survived and developed multiple hepatocellular carcinomas (HCCs). Immunohistochemically, HCC expressed placental form of glutathione-S-transferase (GST-P) and α-fetoprotein, but did not express cytokeratin 19. Y chromosome

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Section: Introductionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Transplanted bone marrow stromal cells are not cellular origin of hepatocellular carcinomas in a mouse model of carcinogenesis

Zheng¹,

Liu²

2008

WJG

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“…The fate of the cells in the human liver is unknown, neither is the mechanism that underlies any improvement clear; one animal study [121] claims that bone marrow cells differentiate to hepatocytes and secrete MMPs that degrade the bands of collagen.…”

Section: Liver Fibrosismentioning

confidence: 99%

Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly

Alison

Islam

Lim

2008

The Journal of Pathology

201

149

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The worldwide shortage of donor livers to transplant end stage liver disease patients has prompted the search for alternative cell therapies for intractable liver diseases, such as acute liver failure, cirrhosis and hepatocellular carcinoma (HCC). Under normal circumstances the liver undergoes a low rate of hepatocyte 'wear and tear' renewal, but can mount a brisk regenerative response to the acute loss of two-thirds or more of the parenchymal mass. A body of evidence favours placement of a stem cell niche in the periportal regions, although the identity of such stem cells in rodents and man is far from clear. In animal models of liver disease, adopting strategies to provide a selective advantage for transplanted hepatocytes has proved highly effective in repopulating recipient livers, but the poor success of today's hepatocyte transplants can be attributed to the lack of a clinically applicable procedure to force a similar repopulation of the human liver. The activation of bipotential hepatic progenitor cells (HPCs) is clearly vital for survival in many cases of acute liver failure, and the signals that promote such reactions are being elucidated. Bone marrow cells (BMCs) make, at best, a trivial contribution to hepatocyte replacement after damage, but other BMCs contribute to the hepatic collagen-producing cell population, resulting in fibrotic disease; paradoxically, BMC transplantation may help alleviate established fibrotic disease. HCC may have its origins in either hepatocytes or HPCs, and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.

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“…MSCs are interesting because they are easily isolated from a small aspirate of bone marrow and readily generate single-cellderived colonies [4] . They can differentiate into different types of cells and for these reasons they are currently being tested for their potential use in cell and gene therapy for a number of diseases [5,6] . Further, MSCs administration could repair injured lung, liver, or heart by reducing inflammation, collagen deposition and remodeling [7].…”

Section: Discussionmentioning

confidence: 99%

Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats

Sakr

Rashed

Zarouk

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Transplantation of Bone Marrow Cells Reduces Ccl4–Induced Liver Fibrosis in Mice

Cited by 500 publications

References 29 publications

Transplanted bone marrow stromal cells are not cellular origin of hepatocellular carcinomas in a mouse model of carcinogenesis

Transplanted bone marrow stromal cells are not cellular origin of hepatocellular carcinomas in a mouse model of carcinogenesis

Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly

Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats

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