Transplantation of insulin-secreting cells differentiated from human adipose tissue-derived stem cells into type 2 diabetes mice

Nam, Ji Sun; Kang, Hyun Mi; Kim, Jiyoung; Park, Seah; Kim, Haekwon; Ahn, Chul Woo; Park, Jin Oh; Kim, Kyung Rae

doi:10.1016/j.bbrc.2013.10.059

Cited by 30 publications

(20 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Later, Xie et al studied the differentiation of human BM-MSCs into IPCs by a three-step process and resulted in them becoming insulin-secreting cells in a glucose dose-dependent manner [233,234]. Similarly, Nam et al performed in vitro differentiation of human eyelid AD-MSCs into IPCs and transplanted them into T2DM mice model [235]. Out of the two groups; T2DM and control, T2DM mice group experienced IPCs mediated improvement, high IL-6 and also an increase in circulating insulin level promoting the metabolic improvements.…”

Section: Mechanistic Details Of Mscs With Clinical Trialsmentioning

confidence: 99%

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Mishra

Shih

Parveen

et al. 2020

Cells

122

View full text Add to dashboard Cite

The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immunosuppression and their therapeutic role in immune disorders. MSCs migrate towards inflamed microenvironments, produce anti-inflammatory cytokines and conceal themselves from the innate immune system. These signatures are the reason for the uprising in the sciences of cellular therapy in the last decades. Irrespective of their therapeutic role in immune disorders, some factors limit beneficial effects such as inconsistency of cell characteristics, erratic protocols, deviating dosages, and diverse transfusion patterns. Conclusive protocols for cell culture, differentiation, expansion, and cryopreservation of MSCs are of the utmost importance for a better understanding of MSCs in therapeutic applications. In this review, we address the immunomodulatory properties and immunosuppressive actions of MSCs. Also, we sum up the results of the enhancement, utilization, and therapeutic responses of MSCs in treating inflammatory diseases, metabolic disorders and diabetes.

show abstract

Section: Mechanistic Details Of Mscs With Clinical Trialsmentioning

confidence: 99%

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Mishra

Shih

Parveen

et al. 2020

Cells

122

View full text Add to dashboard Cite

show abstract

“…However, only a few cases of stem cell-based research were performed recently [118][119][120][121][122] to develop a therapeutic option for type 2 diabetes, as type 1 diabetes has stood as the forefront. Deriving insulinsecreting β-cells from stem cells for treatment of type 1 diabetes seems relatively straightforward compared to developing an alternative treatment option for type 2 diabetes.…”

Section: Challenges and Opportunities For Adscs In Diabetesmentioning

confidence: 99%

Adipose stem cell-based regenerative medicine for reversal of diabetic hyperglycemia

Paek

Kim

Williams

2014

WJD

View full text Add to dashboard Cite

Core tip: Adipose-derived stem cells (ADSCs) can provide a promising cell therapy for treatment of diabetes and associated complications. ADSCs' multipotency allows differentiation into insulin-producing β-cells. Antiinflammatory and immunomodulatory capabilities of ADSCs can facilitate enhanced engraftment of transplanted donor islets. Although many challenges lie ahead for ADSC-based cell therapies are used clinically to treat diabetic hyperglycemia, ADSCs represent a novel treatment option to many diabetic patients worldwide.Paek HJ, Kim C, Williams SK. Adipose stem cell-based regenerative medicine for reversal of diabetic hyperglycemia. World J Diabetes 2014; 5(3): 235-243 Available from:

show abstract

“…Multiple intravenous bone marrow-derived MSC injections normalized hyperglycemia in rats in which T2DM was induced by a high fat diet and STZ (Hao et al, 2013 ). Human adipose tissue-derived MSCs also differentiate into glucose-sensitive insulin-producing cells, which help improve glucose levels and decrease levels of inflammatory cytokines and free fatty acids in T2DM mice (Dave et al, 2013 ; Nam et al, 2013 ). Umbilical cord blood-derived-MSCs have also been shown to differentiate into insulin-producing cells, and these cells expressed pancreatic beta cell development-related genes.…”

Section: Stem Cell Therapies For T2dmmentioning

confidence: 99%

Stem cell transplantation improves aging-related diseases

Ikehara

2014

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. The number of patients with age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, Alzheimer's disease (AD), Parkinson's disease, atherosclerosis, and cancer has increased recently. Aging-related diseases are related to a deficiency of the immune system, which results from an aged thymus and bone marrow cells. Intra bone marrow-bone marrow transplantation (IBM-BMT) is a useful method to treat intractable diseases. This review summarizes findings that IBM-BMT can improve and treat aging-related diseases, including T2DM, osteoporosis and AD, in animal models.

show abstract

Transplantation of insulin-secreting cells differentiated from human adipose tissue-derived stem cells into type 2 diabetes mice

Cited by 30 publications

References 28 publications

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Adipose stem cell-based regenerative medicine for reversal of diabetic hyperglycemia

Stem cell transplantation improves aging-related diseases

Contact Info

Product

Resources

About