Transplantation of islet-like cell clusters derived from human dental pulp stem cells restores normoglycemia in diabetic mice

Kanafi, Mohammad Mahboob; Rajeshwari, Y. B.; Gupta, Sarita; Dadheech, Nidheesh; Nair, Prabha D.; Gupta, Pawan Kumar; Bhonde, Ramesh

doi:10.1016/j.jcyt.2013.05.008

Cited by 79 publications

(76 citation statements)

References 20 publications

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“…In addition to preclinical trials in animals, several clinical trials (phase I/II) have endorsed the safety and efficacy of human MSCs (hMSCs) for myocardial infarction [15], multiple sclerosis [16], kidney transplantation [17], acute ischemic stroke [18] and Parkinson’s disease [19]. Our group has recently shown that MSCs could be effective for the metabolic disorder type II diabetes in STZ-induced diabetic mice without immunosuppression [20]. Furthermore, allogeneic MSCs have been demonstrated to be safe and efficacious for critical limb ischemia (CLI) in a phase I clinical study [21].…”

Section: Introductionmentioning

confidence: 99%

The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration

et al. 2016

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The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their multipotentiality have rendered them attractive to researchers and clinicians. In addition to the differentiation potential, the broad repertoire of secreted trophic factors (cytokines) exhibiting diverse functions such as immunomodulation, anti-inflammatory activity, angiogenesis and anti-apoptotic, commonly referred to as the MSC secretome, has gained immense attention in the past few years. There is enough evidence to show that the one important pathway by which MSCs participate in tissue repair and regeneration is through its secretome. Concurrently, a large body of MSC research has focused on characterization of the MSC secretome; this includes both soluble factors and factors released in extracellular vesicles, for example, exosomes and microvesicles. This review provides an overview of our current understanding of the MSC secretome with respect to their potential clinical applications.

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Section: Introductionmentioning

confidence: 99%

The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration

et al. 2016

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“…78 Carnevale et al 99 reported that hDPSCs under appropriate stimuli express genes related to pancreatic β-cell development and function, including insulin, pancreatic, and duodenal homeobox-1. Kanafi et al 76 demonstrated the transplantation of islet-like cell clusters (ICCs) derived from hDPSC and SHED in diabetic mice. They noticed the reversal of hyperglycemia to the normal level in experimental diabetic mice.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…These observations suggested the use of dental pulp as an autologous stem cell therapy in diabetic patients. 76,100 …”

Section: Diabetes Mellitusmentioning

confidence: 99%

Therapeutic potential of dental stem cells

et al. 2017

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Stem cell biology has become an important field in regenerative medicine and tissue engineering therapy since the discovery and characterization of mesenchymal stem cells. Stem cell populations have also been isolated from human dental tissues, including dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla, dental follicle progenitor cells, and periodontal ligament stem cells. Dental stem cells are relatively easily obtainable and exhibit high plasticity and multipotential capabilities. The dental stem cells represent a gold standard for neural-crest-derived bone reconstruction in humans and can be used for the repair of body defects in low-risk autologous therapeutic strategies. The bioengineering technologies developed for tooth regeneration will make substantial contributions to understand the developmental process and will encourage future organ replacement by regenerative therapies in a wide variety of organs such as the liver, kidney, and heart. The concept of developing tooth banking and preservation of dental stem cells is promising. Further research in the area has the potential to herald a new dawn in effective treatment of notoriously difficult diseases which could prove highly beneficial to mankind in the long run.

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“…Kanafi et al [ 120 ] conducted a study to assess the effi cacy of SHEDs and DPSCs in streptozotocin-induced DM model in mice. It was demonstrated that about 90 % of diabetic mice transplanted with encapsulated stem cell-derived islets survived, and were restored to normoglycemia within 2 weeks after transplantation and maintained normoglycemia for 2 months while their body weight and glucose levels in urine reverted to normal conditions.…”

Section: Islet-like Cells Related Studiesmentioning

confidence: 99%

Dental Stem Cell Differentiation Toward Endodermal Cell Lineages: Approaches to Control Hepatocytes and Beta Cell Transformation

Gnanasegaran¹,

Govindasamy²,

Nathan³

et al. 2016

Dental Stem Cells

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Transplantation of islet-like cell clusters derived from human dental pulp stem cells restores normoglycemia in diabetic mice

Cited by 79 publications

References 20 publications

The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration

The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration

Therapeutic potential of dental stem cells

Dental Stem Cell Differentiation Toward Endodermal Cell Lineages: Approaches to Control Hepatocytes and Beta Cell Transformation

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