Transplantation of Viable Meniscal Allograft

Verdonk, Peter; Demurie, Alex; Almqvist, Karl; Veys, Eric; Verbruggen, Gust; Verdonk, René

doi:10.2106/jbjs.e.00875

Cited by 79 publications

(108 citation statements)

References 23 publications

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“…This allows for all-inside suture fixation of the allograft to the meniscal rim. In addition, the meniscal soft tissue at the anterior and posterior horns may be fixed in tibial tunnels with interference or biotenodesis screw fixation or transosseous suture Anterior horn fixation may be augmented using suture anchors [74]. Alternatively, surgeons may eliminate tibial tunnels and tibial fixation entirely.…”

Section: Open Technique: Medial Double Bone Plugmentioning

confidence: 99%

Meniscus allograft transplantation: a current concepts review

Lubowitz

Verdonk

Reid

et al. 2007

Knee Surg Sports Traumatol Arthrosc

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146

113

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Meniscus allotransplantation represents the biological solution for the symptomatic, meniscus-deficient patient who has not developed advanced osteoarthritis. A growing body of evidence suggests that pain relief and functional improvement may reliably be achieved at short- and medium-term follow-up, and even, in some cases, at long-term (>10 years) follow-up. Future research must address the issue of optimal timing of the procedure and whether meniscal transplantation results in demonstrable long-term benefits, especially with regard to protection of articular cartilage.

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Section: Open Technique: Medial Double Bone Plugmentioning

confidence: 99%

Meniscus allograft transplantation: a current concepts review

Lubowitz

Verdonk

Reid

et al. 2007

Knee Surg Sports Traumatol Arthrosc

Self Cite

146

113

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“…Some indicate that the time of cell survival is very short and in a goat model it does not exceed 1 month (Jackson et al 1993). On the other hand, Verdonk et al (2006) have demonstrated the results of their first 100 meniscal transplantation procedures using fresh allografts. They used 39 medial and 61 lateral menisci.…”

Section: Discussionmentioning

confidence: 99%

“…In the next step, the graft should be placed in a culture medium containing 20 % of the recipient’s serum and stored at 37 °C in continuously controlled environmental conditions. The parameters such as viability of cells in the fresh graft must be carefully documented (Verdonk 2002; Verdonk et al 2006; Schubert et al 2010). …”

Section: Types Of Graftsmentioning

confidence: 99%

Preservation and sterilization methods of the meniscal allografts: literature review

Mickiewicz

Binkowski

Bursig³

et al. 2013

Cell Tissue Bank

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Nowadays, there are four types of meniscal allografts known: fresh, cryopreserved, deep-frozen and lyophilized ones but only two of them are widely used in clinical practice. Use of different types of meniscal allografts still remains controversial due to preparation method, their biomechanical properties as well as cost which is connected with processing and storage. The main aim of this review is to present the current status of knowledge concerning meniscal allograft preservation and sterilization, especially the advantages and disadvantages of each method. Authors wanted to show a broad spectrum of methods used and conceptions presented by other authors. The second aim is to gather available information about meniscal preservation and sterilization methods in one paper. Deep-frozen and cryopreserved meniscal allografts are the most frequently used ones in the clinical practice. The use of fresh grafts stays controversial but also has many followers. Lyophilized grafts in turn are not applied at present due to some serious drawbacks including reduction of tensile strength, poor rehydration, graft shrinkage and post-transplantation joint effusion as well as increased risk of meniscal size reduction. An application of sterilizing agents make the meniscal allograft free from the bacteria and viruses, but also it may cause serious structure changes. Therefore, choosing just one ideal method of meniscal allograft preservation and sterilization is complicated and should be based on broad knowledge and experience of surgeon performing the transplantation.

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“…This result can be achieved with bony fixation of the anterior and posterior horns94,95 and better results were reported using this procedure 96. However, some authors have reported satisfactory results with soft-tissue fixation alone 97,98. Bony fixation requires accurate anatomical graft placement, and cadaveric studies reported poor mechanical properties in case of malpositioning of the bony anchors 99,100.…”

Section: Managementmentioning

confidence: 99%

Meniscal tears

Maffulli

Longo²,

Campi³

et al. 2010

OAJSM

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Abstract:The menisci are two semilunar-shaped fibrocartilagenous structures, which are interposed between the femoral condyles and tibial plateaux. They have an important role in knee function. Long-term follow-up studies showed that virtually all meniscectomized knees develop arthritic changes with time. The meniscus has functions in load bearing, load transmission, shock absorption, joint stability, joint lubrication, and joint congruity. Because of these functions, meniscal tissue should be preserved whenever possible. A well-trained surgeon can safely rely on clinical examination for diagnosing meniscal injuries. History and clinical examination are at least as accurate as magnetic resonance imaging in the skilled orthopedic surgeon's hand. When meniscal repair is not possible, partial resection of the meniscus is indicated. Meniscal repair has evolved from open to arthroscopic techniques, which include the inside-out and outside-in suture repairs and the all-inside techniques. Meniscal transplantation is generally accepted as a management alternative option for selected symptomatic patients with previous complete or near-complete meniscectomy.

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Transplantation of Viable Meniscal Allograft

Cited by 79 publications

References 23 publications

Meniscus allograft transplantation: a current concepts review

Meniscus allograft transplantation: a current concepts review

Preservation and sterilization methods of the meniscal allografts: literature review

Meniscal tears

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