Transplantation Tolerance Across Major Histocompatibility Barriers After Total Lymphoid Irradiation

Evolution of Liver Transplantation

“…Efforts to use preoperative TDD in liver recipients usually created insurmountable problems because of the prodigious quantities (as much as 2 liters per hr) of thoracic duct lymph which patients with hepatic insufficiency produced (80). Lymphoid depletion by total lymphoid irradiation for conditioning before grafting (81,82) has not been tried in liver recipients.…”

The Pretreatment Principle in Renal Transplantation as Illustrated by Thoracic Duct Drainage

“…We have treated two livec recipients and one kidney recipient in this way. The procedures of total lymphoid irradiation (25) and thymectomy are variations on the same theme. So would be pretransplantation conditioning with powerful antilymphocyte sera and globulins, an approach that has been made impractical in patients by immune reactions to the heterologous protein (22).…”

Transplantation: The realization of a dream

“…At the outset of this editorial, it was mentioned that one of the first forms of immunosuppression was with irradiation, and this therapeutic possibility has been kept alive by research with total lymphoid irradiation plus drug therapy and antigenic challenge for tolerance induction. 33,34 Diagnostic radiology has played such an important role that transplantation has become the most "radiology-intense" of all specialties. [35][36][37] The function and anatomic integrity of transplanted organs has been studied with the rapidly evolving radiologic techniques of the last quarter century, including radio nuclide scanning, the diagnostic and therapeutic procedures of interventional radiology, and particularly in the last 10 years with the mass utilization of the imaging techniques.…”