Transplante de membrana amniótica associado ao transplante de conjuntiva autólogo no tratamento do pterígio primário

Castellano, Alessandra Guerra Daros; Malfatti, Fernando Antonio; Zago, Rommel Josué; Carvalho, Ana Cristina Alvarez de; Reichmann, Rafael Potrich; Moreira, Hamílton

doi:10.1590/s0004-27492005000500016

Arq. Bras. Oftalmol.

2005

DOI: 10.1590/s0004-27492005000500016

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Transplante de membrana amniótica associado ao transplante de conjuntiva autólogo no tratamento do pterígio primário

Alessandra Guerra Daros Castellano¹,

Fernando Antonio Malfatti²,

Rommel Josué Zago³

et al.

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2014

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Transplantation of the allogeneic conjunctiva and conjunctival extracellular matrix

D¹,

Wang²,

H³

2014

BLL

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Objectives: To investigate the characteristics and effects of allogenic conjunctiva and conjunctival extracellular matrix (ECM) as the substitute of conjunctival tissues. Background: The symptoms of the frequently-occurring conjunctival injury not only make people ugly, but also lead to blindness, which seriously endanger the quality of life of the patients. Methods: The bulbar conjunctivas of 6 out of 30 rabbits were prepared into a conjunctival defect model, and the remaining rabbits were randomly divided into 2 groups (n = 12). The conjunctivas of the trial group were repaired by transplanting conjunctival ECM prepared by tissue engineering technology, and the control group received fresh conjunctival allograft. Thereafter, the postoperative conjunctival reconstruction was observed. Their conjunctivas were examined by naked eye, microscope, immunohistochemical and lymphocyte toxicity tests. Results: Blood vessels of the trial group began to grow into the graft after one week, and the conjunctivas appeared almost normal without immune rejection after 8 weeks. The transplanted conjunctival epitheliums were observed to recover after 4 weeks under light microscope. A large number of invasive infl ammatory cells were found in the grafts of the control group 2 weeks after surgery. Conclusion: Conjunctival ECM is an ideal substitute for conjunctiva, which can be used for the effective surface reconstruction of cornea and conjunctiva (Fig. 7, Ref.

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Transplantation of the allogeneic conjunctiva and conjunctival extracellular matrix

D¹,

Wang²,

H³

2014

BLL

View full text Add to dashboard Cite

show abstract

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Transplante de membrana amniótica associado ao transplante de conjuntiva autólogo no tratamento do pterígio primário

Cited by 1 publication

References 16 publications

Transplantation of the allogeneic conjunctiva and conjunctival extracellular matrix

Transplantation of the allogeneic conjunctiva and conjunctival extracellular matrix

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