Lateral superlattices have attracted major interest as this may allow one to modify spectra of two dimensional (2D) electron systems and, ultimately, create materials with tailored electronic properties 1-8 . Previously, it proved difficult to realize superlattices with sufficiently short periodicity and weak disorder, and most of the observed features could be explained in terms of commensurate cyclotron orbits 1-4 . Evidence for the formation of superlattice minibands (so called Hofstadter's butterfly 9 ) has been limited to the observation of new low-field oscillations 5 and an internal structure within Landau levels 6-8 . Here we report transport properties of graphene placed on a boron nitride substrate and accurately aligned along its crystallographic directions. The substrate's moiré potential 10-12 leads to profound changes in graphene's electronic spectrum. Second-generation Dirac points 13-22 appear as pronounced peaks in resistivity accompanied by reversal of the Hall effect. The latter indicates that the sign of the effective mass changes within graphene's conduction and valence bands. Quantizing magnetic fields lead to Zak-type cloning 23 of the third generation of Dirac points that are observed as numerous neutrality points in fields where a unit fraction of the flux quantum pierces the superlattice unit cell. Graphene superlattices open a venue to study the rich physics expected for incommensurable quantum systems 7-9,22-24 and illustrate the possibility to controllably modify electronic spectra of 2D atomic crystals by using their crystallographic alignment within van der Waals heterostuctures 25 .Since the first observation of Weiss oscillations 1,2 , 2D electronic systems subjected to a periodic potential have been studied in great detail [3][4][5][6][7][8] . The advent of graphene has rapidly sparked interest in its superlattices, too [13][14][15][16][17][18][19][20][21][22] . The principal novelty in this case is the Dirac-like spectrum and the fact that charge carriers are not buried deep under the surface, allowing a relatively strong superlattice potential on a true nanometer scale. One promising avenue for making nanoscale graphene superlattices is the use of a potential induced by another crystal. For example, graphene placed on top of graphite or hexagonal boron nitride (hBN) exhibits a moiré pattern [10][11][12]26 , and graphene's tunneling density of states becomes strongly modified 12,26 indicating the formation of superlattice minibands. The spectral reconstruction occurs near the edges of superlattice's Brillouin zone (SBZ) that are characterized by wavevector G =4/ D and energy E S =v F G/2 (D is the superlattice period and v F graphene's Fermi velocity) 12,22 .To observe moiré minibands in transport properties, graphene has to be doped so that the Fermi energy reaches the reconstructed part of the spectrum. This imposes severe constraints on the misalignment angle of graphene relatively to hBN. Indeed, D is given by and the 1.8% difference between the two lattice constants ...