Transport studies of β-lactam antibiotics and their degradation products across electrified water/oil interface

Simultaneous determination of three carbapenem antibiotics in plasma by HPLC with ultraviolet detection

“…Phosphate buffer 0.1 M (pH 6.8) was used as aqueous part of mobile phase, because of carbapenems low stability at basic or acidic pH [22,27,28,34]. Initial tests were performed in isocratic mode using 20% methanol.…”

Interface Between Two Immiscible Liquid Electrolytes: A Review

“…One of the early work demonstrated determination of monensin, useful in synthesis of this compound for cattle feed [50][51][52][53][54] , or nigericin 55,56 . Valinomycin, which forms very selective complex with potassium, was studied on such ITIES [57][58][59][60][61][62][63] as were β-lactam antibiotics and their derivatives 64 , the channel former alamecithin 65 . It is not without interest that antibiotics can be also synthesized, using a two phase method, on a liquidliquid interface 66,67 The interface is also a natural site where polar and in particular large molecules can be absorbed.…”

Column-switching technique for the sensitive determination of ertapenem in human cerebrospinal fluid using liquid chromatography and ultraviolet absorbance detection

“…Ertapenem and other ␤-lactams are unstable in an acidic environment and will tend to convert to the open-ring form [2,6]. However, no conversion of ertapenem to the open-ring form was detected using this assay, possibly because of the short time the drug was exposed to the acidic mobile phase: ertapenem eluted in approximately 7 min and was probably protected from the acid by partitioning into the oily C18 stationary phase.…”