Transport through crosslinked poly(2‐hydroxyethyl methacrylate) hydrogel membranes

Abstract

SummaryThe transport of urea and other biologically interesting solutes in aqueous solution across poly(2-hydroxyethyl methacrylate) (p-HEMA) hydrogel membranes has been studied. The results show that p-HEMA membranes have a high permeability to urea due to a strong interaction between the polymer and urea, and, in addition, they are consistent with a pore flow model in which solute transport takes place through water-filled regions essentially unaffected by the surrounding polymer matrix. The results indicate that such p-HEMA membranes might be suitable for hemodialysis applications.

Proangiogenic scaffolds as functional templates for cardiac tissue engineering

“…Bimodal scaffolds having interconnected spherical pore regions and channels with high aspect ratios were templated from poly (methyl methacrylate) (PMMA) beads and polycarbonate (PC) core/PMMA optical fiber (POF) shell according to published methods (10, 13) with slight modifications (SI Materials and Methods). The template was infiltrated with monomer solution (2-HEMA and 5% MAA) using tetraethylene glycol dimethacrylate as a cross-linker and Irgacure 651 (Ciba) as a UV initiator (38). The PC/PMMA template was solubilized in dichloromethane over 5 d; then the hydrogel was rehydrated to water and surface derivatized with rat tail collagen I (BD) using ethyl(dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) chemistry.…”

Water transport in 2-hydroxyethyl methacrylate copolymer irradiated by ? rays in air and related phenomena

“…The 2-hydroxyethyl methacrylate (HEMA) copolymers have been widely studied and employed as biomaterials, including soft contact lenses, 1,2 kidney dialysis systems, 3,4 drug delivery systems 5,6 and artificial liver support systems. 7,8 The presence of a hydroxyl group and a carbonyl group on each repeated unit makes the polymers compatible with water, and the hydrophobic ␣-methyl group and backbone impart hydrolytic stability to the polymers and support the mechanical strength of the polymer matrix.…”

Self-assembled molecular structures as ultrasonically-responsive barrier membranes for pulsatile drug delivery

“…11,12 Briefly, 5 g of the HEMA monomer and 0.2 g of the TEGDMA crosslinking agent were added to a water/ethylene glycol mixed solvent (1 g/1.5 g) containing 0.5 mL each of 15% sodium metabisulfite and 40% ammonium persulfate as redox initiators to begin the radical polymerization (formulation B, Table I). …”

“…11,[21][22][23][24][25] Using the established methodology, we have incorporated ciprofloxacin, an FDA-approved antibiotic, in homogeneous pHEMA matrices crosslinked with TEGDMA (formulation B, Table I). This antibiotic-containing polymer was further coated with C12 isocyanate to form a diffusional membrane consisting of ordered, crystalline methylene chains.…”