High-amplitude radial pulsations of a single gas bubble in several glycerine and water mixtures have been observed in an acoustic stationary wave system at acoustic pressure amplitudes on the order of 150 kPa ( 1.5 atm) at 21-25 kHz. Sonoluminescence (SL), a phenomenon generally attributed to the high temperatures generated during the collapse of cavitation bubbles, was observed as short light pulses occurring once every acoustic period. These emissions can be seen to originate at the geometric center of the bubble when observed through a microscope. It was observed that the light emissions occurred simultaneously with the bubble collapse. Using a laser scattering technique, experimental radius-time curves have been obtained which confirm the absence of surface waves, which are expected at pressure amplitudes above 100 kPa. [S. Horsburgh, Ph.D. dissertation, University of Mississippi (1990) ]. Also from these radius-time curves, measurements of the pulsation amplitude, the timing of the major bubble collapse, and the number of rebounds were made and compared with several theories. The implications of this research on the current understanding of cavitation related phenomena such as rectified diffusion, surface wave excitation, and sonoluminescence are discussed.

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The standard approach to the analysis of the pulsations of a driven gas bubble is to assume that the pressure within the bubble follows a polytropic relation of the form p=p0(R0/R)3κ, where p is the pressure within the bubble, R is the radius, κ is the polytropic exponent, and the subscript zero indicates equilibrium values. For nonlinear oscillations of the gas bubble, however, this approximation has several limitations and needs to be reconsidered. A new formulation of the dynamics of bubble oscillations is presented in which the internal pressure is obtained numerically and the polytropic approximation is no longer required. Several comparisons are given of the two formulations, which describe in some detail the limitations of the polytropic approximation.

Acoustic characterization of high intensity focused ultrasound ͑HIFU͒ fields is important both for the accurate prediction of ultrasound induced bioeffects in tissues and for the development of regulatory standards for clinical HIFU devices. In this paper, a method to determine HIFU field parameters at and around the focus is proposed. Nonlinear pressure waveforms were measured and modeled in water and in a tissue-mimicking gel phantom for a 2 MHz transducer with an aperture and focal length of 4.4 cm. Measurements were performed with a fiber optic probe hydrophone at intensity levels up to 24 000 W / cm 2 . The inputs to a Khokhlov-Zabolotskaya-Kuznetsov-type numerical model were determined based on experimental low amplitude beam plots. Strongly asymmetric waveforms with peak positive pressures up to 80 MPa and peak negative pressures up to 15 MPa were obtained both numerically and experimentally. Numerical simulations and experimental measurements agreed well; however, when steep shocks were present in the waveform at focal intensity levels higher than 6000 W / cm 2 , lower values of the peak positive pressure were observed in the measured waveforms. This underrepresentation was attributed mainly to the limited hydrophone bandwidth of 100 MHz. It is shown that a combination of measurements and modeling is necessary to enable accurate characterization of HIFU fields.