Transportation and Routine Veterinary Interventions Alter Immune Function in the Dog

DeClue, Amy E.; Axiak‐Bechtel, Sandra M.; Cowan, Cynthia Friedman; Zhang, Yan; Amorim, Juliana; Halpin, Rachel; Melillo, Gabrielle N; Hagan, Catherine E.

doi:10.1016/j.tcam.2020.100408

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…For example, chronic heat stress in dairy cows enhances a pro-inflammatory state (Koch et al, 2023) as well as acute and intense exercise in American Quarter Horses (Wilson et al, 2023). Stress induced by transportation and hospitalization in healthy dogs is associated with alteration in the immune function characterized by increased immune cells apoptosis and downregulation of major histocompatibility complex class II within neutrophils and macrophages (DeClue et al, 2020).…”

Section: Infl Ammationmentioning

confidence: 99%

“…For example, chronic heat stress in dairy cows enhances a pro‐inflammatory state (Koch et al, 2023) as well as acute and intense exercise in American Quarter Horses (Wilson et al, 2023). Stress induced by transportation and hospitalization in healthy dogs is associated with alteration in the immune function characterized by increased immune cells apoptosis and downregulation of major histocompatibility complex class II within neutrophils and macrophages (DeClue et al, 2020). Therefore, inflammation and immune response could be seen as the boundary between a controlled stress response by protecting and favouring adaptation to stress, and a dysregulated stress response by resulting in diseases or worsening the initial pathological state, including reproductive disorders (Rohleder, 2019).…”

Section: Inflammationmentioning

confidence: 99%

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Pathogenesis of the crosstalk between reproductive function and stress in animals – part 2: Prolactin, thyroid, inflammation and oxidative stress

Jaillardon,

Kaiser

2023

Reprod Domestic Animals

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Stress has a significant impact on reproductive health and fertility in both humans as well as various animal species. In particular, chronic stress can disrupt the delicate balance of the hormonal system that regulates reproductive function, leading to a variety of reproductive disorders and fertility issues. Beside the action of the hypothalamic‐pituitary‐adrenal (HPA) system and the sympatho‐adrenomedullary system (SAM), other subsequent mechanisms have been incriminated. Thus, stress has also been associated with increased prolactin level, resulting in an inhibition of the hypothalamo‐pituitary‐gonadal (HPG) system leading to several reproductive disorders. Thyroid function is inhibited during chronic stress, and therefore considered an important regulator of reproductive function. Thus, and in particular by interfering with the HPA system, stress‐induced immune dysregulation can have adverse effects on reproduction. In addition, oxidative stress and inflammation have been proposed as potential mechanisms by which chronic stress affects reproductive function. This is caused by an increase in reactive oxygen species (ROS) production that has a harmful effect on cells. Furthermore, inflammation can lead to tissue damage and scarring, which can affect fertility. The present review completes the complex mechanism linking stress and reproduction through the current knowledge in various animal species in a comparative point of view.

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Section: Infl Ammationmentioning

confidence: 99%

Section: Inflammationmentioning

confidence: 99%

Pathogenesis of the crosstalk between reproductive function and stress in animals – part 2: Prolactin, thyroid, inflammation and oxidative stress

Jaillardon,

Kaiser

2023

Reprod Domestic Animals

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How to evaluate and manage stress in dogs – A guide for veterinary specialist

Kartashova¹,

Ganina²,

Karelina³

et al. 2021

Applied Animal Behaviour Science

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Effects of a Saccharomyces cerevisiae fermentation product-supplemented diet on fecal characteristics, oxidative stress, and blood gene expression of adult dogs undergoing transport stress

Wilson

Oba

Applegate

et al. 2022

Journal of Animal Science

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Previously, a Saccharomyces cerevisiae fermentation product (SCFP) was shown to positively alter fecal microbiota, fecal metabolites, oxidative stress, and circulating immune cell function of adult dogs. The objective of this study was to measure the effects of SCFP on fecal characteristics, serum oxidative stress biomarkers, and whole blood gene expression of dogs undergoing transport stress. Sixteen adult pointer dogs [8M, 8F; mean age = 6.7 ± 2.1 y; mean body weight (BW) = 25.5 ± 3.9 kg] were used in a randomized crossover design study. All dogs were fed a control diet for 4 weeks, then randomly assigned to a control or SCFP-supplemented diet (formulated to include approximately 0.13% of the active SCFP ingredient) and fed to maintain BW for 11 weeks. A 6-week washout preceded the second 11-week experimental period with dogs receiving opposite treatments. After 11 weeks, fresh fecal and blood samples were collected before and after transport in a van for 45 minutes. Change from baseline data (i.e., before and after transport) were analyzed using the Mixed Models procedure of SAS 9.4, with P < 0.05 being significant and P < 0.10 being trends. Change in serum malondialdehyde concentrations increased (P < 0.05) and serum 8-isoprostane concentrations tended to increase (P < 0.10) in dogs fed SCFP, but decreased (P < 0.05) in control dogs after transport. Other serum markers were unaffected by diet during transport stress. Fecal dry matter percentage tended to be affected (P < 0.10) by diet during transport stress, being reduced in control dogs, but stable in dogs fed SCFP. Other fecal characteristics were unaffected by diet during transport stress. Genes associated with activation of innate immunity were impacted by diet in response to transport stress, with blood cyclooxygenase-2 and malondialdehyde mRNA expression being increased (P < 0.05) in control dogs, but stable or decreased in dogs fed SCFP. Expression of other genes was unaffected by diet during transport stress. These data suggest that the benefits of feeding a SCFP during transport stress may be mediated through suppression of innate immune cell activation.

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Transportation and Routine Veterinary Interventions Alter Immune Function in the Dog

Cited by 3 publications

References 41 publications

Pathogenesis of the crosstalk between reproductive function and stress in animals – part 2: Prolactin, thyroid, inflammation and oxidative stress

Pathogenesis of the crosstalk between reproductive function and stress in animals – part 2: Prolactin, thyroid, inflammation and oxidative stress

How to evaluate and manage stress in dogs – A guide for veterinary specialist

Effects of a Saccharomyces cerevisiae fermentation product-supplemented diet on fecal characteristics, oxidative stress, and blood gene expression of adult dogs undergoing transport stress

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