Transporter-mediated Regulation of Pharmacokinetics of Lifestyle-related Substances

Takada, Tappei

doi:10.1248/yakushi.12-00258

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Other therapeutics such as XDH inhibitors also share similar shortcomings [ 14 ]. According to some scientists, if endogenous uric acid was excreted through intestinal tract [ 15 ], then the drug treatment for hyperuricemia could be done locally, which in turn avoid the systemic adverse reactions.…”

Section: Introductionmentioning

confidence: 99%

Intestinal tract is an important organ for lowering serum uric acid in rats

Yin

Gao

et al. 2017

PLoS ONE

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The kidney was recognized as a dominant organ for uric acid excretion. The main aim of the study demonstrated intestinal tract was an even more important organ for serum uric acid (SUA) lowering. Sprague-Dawley rats were treated normally or with antibiotics, uric acid, adenine, or inosine of the same molar dose orally or intraperitoneally for 5 days. Rat’s intestinal tract was equally divided into 20 segments except the cecum. Uric acid in serum and intestinal segment juice was assayed. Total RNA in the initial intestinal tract and at the end ileum was extracted and sequenced. Protein expression of xanthine dehydrogenase (XDH) and urate oxidase (UOX) was tested by Western blot analysis. The effect of oral UOX in lowering SUA was investigated in model rats treated with adenine and an inhibitor of uric oxidase for 5 days. SUA in the normal rats was 20.93±6.98 μg/ml, and total uric acid in the intestinal juice was 308.27±16.37 μg, which is two times more than the total SUA. The uric acid was very low in stomach juice, and attained maximum in the juice of the first segment (duodenum) and then declined all the way till the intestinal end. The level of uric acid in the initial intestinal tissue was very high, where XDH and most of the proteins associated with bicarbonate secretion were up-regulated. In addition, SUA was decreased by oral UOX in model rats. The results suggested that intestinal juice was an important pool for uric acid, and intestinal tract was an important organ for SUA lowering. The uric acid distribution was associated with uric acid synthesis and secretion in the upper intestinal tract, and reclamation in the lower.

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Section: Introductionmentioning

confidence: 99%

Intestinal tract is an important organ for lowering serum uric acid in rats

Yin

Gao

et al. 2017

PLoS ONE

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Translational Research Based on Understanding the Regulatory Mechanisms of <i>in Vivo</i> Behaviors of Fat-soluble Compounds

Yamanashi

2019

YAKUGAKU ZASSHI

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Several fat-soluble compounds such as cholesterol and fat-soluble vitamins have important physiological activities in the body, and their excess and/or deˆciency have been reported to be closely associated with the onset and progression of several conditions such as lifestyle-related diseases. It is important to clarify not only the physiological activities but also in vivo kinetics of fat-soluble compounds to understand their in vivo activity (toxicity). This review introduces our recent (reverse) translational research in a combination of basic and clinical studies to reveal the regulatory mechanisms of in vivo behaviors of fat-soluble compounds and eŠects of their disruption in humans.

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Transporter-mediated Regulation of Pharmacokinetics of Lifestyle-related Substances

Cited by 2 publications

References 33 publications

Intestinal tract is an important organ for lowering serum uric acid in rats

Intestinal tract is an important organ for lowering serum uric acid in rats

Translational Research Based on Understanding the Regulatory Mechanisms of <i>in Vivo</i> Behaviors of Fat-soluble Compounds

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