Transrectal ultrasound versus magnetic resonance imaging for detection of rectal wall invasion by prostate cancer

Leibovici, Dan; Kamat, Ashish M.; A., Kim; Pettaway, Curtis A.; Ng, Chaan S.; Evans, Robert B.; Rodrı́guez-Bigas, Miguel A.; Skibber, John M.; Wang, Xuemei; Pisters, Louis L.

doi:10.1002/pros.20127

Cited by 18 publications

(5 citation statements)

References 17 publications

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“…The possible explanation is local control, removing the potential source of future metastases, and improving the response to systemic therapy [44]. Although it is inappropriate to make inferences regarding the role of TPE in the management of prostate cancer with rectal involvement based on the findings in this retrospective review, we and others [49] believe that TPE should be further evaluated as treatment strategies for selected patients, especially in nonextrarectal metastatic hormonally untreated patients, because they may provide better local control and a potential long-term survival and cure.…”

Section: Discussionmentioning

confidence: 96%

Factors associated with the survival of prostate cancer patients with rectal involvement

Wang

Yao

2014

Diagn Pathol

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BackgroundProstate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated.Patients and methodsWe collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in the literature. The associations of clinical characteristics with survival were evaluated using Cox regression models.ResultsThis study included 94 patients (5 admitted to our hospital and 89 from studies in the literature) of prostate cancer with rectal involvement. 11 patients in the group of synchronous rectal involvement at first cancer diagnosis (n = 58) and 23 patients in the group of metachronous diagnosis of rectal involvement (n = 29) died at the latest follow up. The estimated overall survival rate (% ± SE) at 1, 3, and 5 years were 68.3 ± 5.3%, 54.4 ± 7.2%, and 38.1 ± 11.1%, respectively. In the Cox univariate analysis, Asian prostate cancer (p = 0.001) was associated with better survival, while rectal bleeding (p = 0.043), metachronous presentation of development of rectal involvement (p = 0.000), prior hormonal therapy (p = 0.000) and extrarectal metastases (p = 0.054) were associated with poor survival. In multivariate analysis, prior hormone therapy (HR = 14.540, p = 0.000) and rectal bleeding (HR = 2.195, p = 0.041) retained independent poor prognostic values. There were 13 patients survived for more than 3 years, the longest survival time was 96 months. Total pelvic extenteration (TPE) combined with hormonal therapy in 12 hormone-untreated prostate cancer give us six of thirteen long-term survivors for more than 3 years in this series.ConclusionsOur findings suggest that rectal involvement does not necessarily predict a worse outcome when presenting as a previously hormone-untreated disease and that the prognosis was worse when presenting as a hormone relapsed disease. Prior hormone therapy and rectal bleeding were associated independently with a significantly poor overall survival in prostate cancer patients with rectal involvement. TPE combined with hormonal therapy appears to confer better overall survival in hormonally untreated patients.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1604504118106105.

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Section: Discussionmentioning

confidence: 96%

Factors associated with the survival of prostate cancer patients with rectal involvement

Wang

Yao

2014

Diagn Pathol

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“…Recently, two more studies on larger cohorts of patients comparing TRUS versus MRI in staging of prostate and rectal cancer were published (25,26) . Both studies found higher accuracy achieved using TRUS than MRI.…”

Section: Discussionmentioning

confidence: 99%

Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer

Fischerová¹,

Cibula²,

Stenhova³

et al. 2008

International Journal of Gynecological Cancer

134

114

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The goal of this study was to determine the sensitivity, specificity, and accuracy of transrectal ultrasound (TRUS) in comparison to magnetic resonance imaging (MRI) in the evaluation of tumor volume, early parametrial infiltration, and identification of residual tumor in early-stage cervical cancer. Patients in whom an early-stage cervical cancer was diagnosed by clinical examination were enrolled in the study. Only those patients who were examined by both MRI and TRUS with following surgical treatment were included. Imaging results were compared with pathology findings. Altogether, 120 patients were consecutively enrolled from January 2004 to February 2006. Data from 95 patients were evaluated. Correlation coefficient for TRUS- and MRI-derived volumes versus volumes at pathology reached R = 0.996 and R = 0.980, respectively. The accuracy for detecting tumor in 95 patients was 93.7% for TRUS and 83.2% for MRI (P

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“…3D‐TRUS was a simple and easy investigation, which did not require special preparation. It is cheap, by contrast with other imaging methods of current interest, especially endorectal MRI [15]. 3D‐TRUS is easy to interpret by experts in conventional TRUS.…”

Section: Discussionmentioning

confidence: 99%

The value of three‐dimensional transrectal ultrasonography in staging prostate cancer

et al. 2007

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RESULTSPathological staging of specimens showed extracapsular extension in 69 patients, of whom 53 had pathological capsular perforation and 16 had seminal vesicle invasion. 3D-TRUS identified 58 patients with sites of extracapsular extension with 84% sensitivity, 96% specificity, 94% positive predictive value, 91% negative predictive value and an overall accuracy of 92%. Of the 16 patients with seminal vesicle invasion 14 were identified correctly on 3D-TRUS. Overall the 3D-TRUS staging sensitivity was 84%, specificity 96%, positive predictive value 93%, negative predictive value 91% and accuracy 91%. CONCLUSIONS3D-TRUS seems to be an accurate technique for staging localized prostate cancer. If 3D-TRUS indicates locally advanced disease, the probability of capsular perforation or seminal vesicle invasion is very high.

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Transrectal ultrasound versus magnetic resonance imaging for detection of rectal wall invasion by prostate cancer

Abstract: TRUS is a highly sensitive diagnostic modality for rectal wall involvement in patients with locally advanced prostate cancer. Although MRI is very specific, it cannot reliably rule out rectal involvement in the presence of a positive TRUS.

Cited by 18 publications

References 17 publications

Factors associated with the survival of prostate cancer patients with rectal involvement

Factors associated with the survival of prostate cancer patients with rectal involvement

Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer

The value of three‐dimensional transrectal ultrasonography in staging prostate cancer

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