Transverse myelitis related to COVID-19 infection

Zachariadis, Alexandros; Tulbu, Anca; Strambo, Davide; Dumoulin, Alexis; Virgilio, Gabriella Di

doi:10.1007/s00415-020-09997-9

Cited by 54 publications

(77 citation statements)

References 6 publications

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“… Acute demyelination 7 Acute disseminated encephalomyelitis (ADEM) 4 Articles [ 120 ], [ 121 ], [ 122 ], [ 123 ] 4 2M 2F 61(51–71) Reichard RR et al [ 122 ], study reported post-mortem examinations of a 71 Y/O M which revealed ADEM-like appearance at the brain biopsy. 8 Acute Myelitis 5 Articles [ 125 ], [ 126 ], [ 127 ], [ 128 ], [ 129 ] 5 3M 2F 55.6(22–69) In one of these patients [ 125 ] CSF or MRI exam was not performed. Sotoca J et al [ 127 ], reported 69 y/o F acute necrotizing myelitis.…”

Section: Resultsmentioning

confidence: 99%

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

186

182

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Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. Methods: This systematic review serves to summarize available information regarding the potential effects of different types of CoV on the nervous system and describes the range of clinical neurological complications that have been reported thus far in COVID-19. Results: Two hundred and twenty-five studies on CoV infections associated neurological manifestations in human were reviewed. Of those, 208 articles were pertinent to COVID-19. The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. Conclusion: There are several similarities between neurological complications after SARS-CoV-1, MERS-CoV and COVID-19, however, the scope of the epidemics and number of patients are very different. Reports on the neurological complications after and during COVID-19 are growing on a daily basis. Accordingly, comprehensive knowledge of these complications will help health care providers to be attentive to these complications and diagnose and treat them timely.

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Section: Resultsmentioning

confidence: 99%

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

186

182

View full text Add to dashboard Cite

show abstract

“…There are also multiple descriptions of CNS pathological observations that include a predominance of reports of cerebrovascular injury, such as diffuse cerebral ischemia, ischemic and hemorrhagic stroke, microhemorrhages, white matter microangiopathy, and arterial thrombosis as well as meningitis, encephalitis, acute transverse myelitis (ATM), and encephalopathy 4,20,23,24,27,29,30,39,40,67,70,72,76,90,100,102,103,109,[123][124][125][126] (see also other works 24,69,121,[127][128][129][130][131][132]. Investigators have also observed associations between magnetic resonance (MRI) abnormalities and neurological deficits persisting in 55% of hospitalized patients 3 months after disease onset.…”

Section: Clinical Presentationsmentioning

confidence: 99%

Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

DeKosky

Kochanek

Valadka

et al. 2021

Journal of Neurotrauma

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are worldwide descriptions of neurological deficits in COVID-19 patients. Central nervous system (CNS) symptoms can be present early in the course of the disease. As many as 55% of hospitalized COVID-19 patients have been reported to have neurological disturbances three months after infection by SARS-CoV-2. The mutability of the SARS-COV-2 virus and its potential to directly affect the CNS highlight the urgency of developing technology to diagnose, manage, and treat brain injury in COVID-19 patients. The pathobiology of CNS infection by SARS-CoV-2 and the associated neurological sequelae of this infection remain poorly understood. In this review, we outline the rationale for the use of blood biomarkers (BBs) for diagnosis of brain injury in COVID-19 patients, the research needed to incorporate their use into clinical practice, and the improvements in patient management and outcomes that can result. BBs of brain injury could potentially provide tools for detection of brain injury in COVID-19

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“…A French study in 58 intensive-care unit (ICU) patients further reported a high frequency of encephalopathy and corticospinal signs 1 . Since then, a variety of neurological complications have been described, including cerebrovascular complications [2][3][4][5] , encephalitis 6,7 , acute disseminated encephalomyelitis (ADEM) 8 , seizures 9,10 , myelitis 11 , Guillain-Barré syndrome 12 , cranial nerve palsies 13,14 , anosmia and dysgeusia [15][16][17] . Several studies have raised concerns about a high prevalence of anxiety, mood disorders and posttraumatic stress disorders in Covid-19 patients 18 .…”

Section: Introductionmentioning

confidence: 99%

The wide spectrum of neuropsychiatric complications in Covid-19 patients within a multidisciplinary hospital context

Delorme

Houot

Rosso

et al. 2020

Preprint

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Objective: To describe the spectrum of neurological and psychiatric complications in patients with Covid-19 seen in a multidisciplinary center over six months. Methods: We conducted a retrospective, observational study on all patients showing neurological or psychiatric symptoms in the context of Covid-19 seen in the Department of Neurology and Psychiatry of the APHP-Sorbonne University. We collected demographic data, medical and treatment history, comorbidities, symptoms, date of onset, and severity of Covid-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from cerebrospinal fluid (CSF) analysis, brain magnetic resonance (MRI) imaging, 18-fluorodesoxyglucose-position emission computed tomography (FDG-PET/CT)), electroencephalography (EEG) and electroneuromyography (ENMG). Results: 245 patients were included in the analysis. One-hundred fourteen patients (47%) were admitted to the intensive care unit (ICU) and 10 (4%) died. The most frequently reported neuropsychiatric symptoms were motor deficit (41%), cognitive disturbance (35%), impaired consciousness (26%), psychiatric disturbance (24%), headache (20%) and behavioral disturbance (18%). The most frequent syndromes diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%), and cerebrovascular disorders (16%). No patients showed evidence of SARS-CoV-2 in their CSF. Encephalopathy was associated with greater age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the ICU. Conclusions: The majority of the neuropsychiatric complications recorded could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders.

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Transverse myelitis related to COVID-19 infection

Cited by 54 publications

References 6 publications

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

The wide spectrum of neuropsychiatric complications in Covid-19 patients within a multidisciplinary hospital context

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