Tratamento da anemia ferropriva com ferro por via parenteral

Cançado, Rodolfo Delfini; Lobo, Clarisse; Friedrich, J

doi:10.1590/s1516-84842010005000066

Cited by 12 publications

(14 citation statements)

References 21 publications

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“…15,16 While intravenous (IV) iron by passes these problems, fear remains about its harmful effects and the potential for long-term hazards from multiple doses of iron administration. 17,18 Parenteral iron preparations which were available in the olden days were associated with dangerous complications like anaphylactic reactions and death, due to which they have gone in disrepute. 19 The high-molecular-weight iron dextran formulation most frequently were responsible for these side effects seen in 2.3% of the patients.…”

Section: Discussionmentioning

confidence: 99%

Intravenous iron sucrose for treatment of anemia in gynecology patients awaiting surgery

Gandhi

Satia

2016

Int J Reprod Contracept Obstet Gynecol

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Background: Anemia refers to reduction in the total circulatory erythrocyte mass which results in decrease in the oxygen carrying capacity of the blood. Patients who require a surgical intervention as regards their complaints are many a times denied fitness because of anemia. Current anesthetic and surgical practice ideally recommend a hemoglobin level of > 10 g/dl or a hematocrit of >30 % for any surgical intervention. Surgery is postponed until cause of anemia is identified and the anemia corrected without resorting to blood transfusions. The current study evaluates other alternatives to increase the hemoglobin as early as possible without resorting to blood transfusion. The efficacy and safety of intravenous iron sucrose along with the achievement of the desired hemoglobin values for patients posted for elective gynecological surgeries within the next menstrual cycle was evaluated. Methods: This study was an open label, single arm, and prospective study of women with iron deficiency anemia in gynecological disorders. 100 patients attending Gynecology OPD of Seth G. S. Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India requiring surgical intervention but not given fitness due to anaemia were the subjects of this study. All patients with surgically treatable conditions with hemoglobin level >7g/dL but < 10 g/dl were the inclusion criteria Selected subjects received intravenous iron sucrose. Maximum dose 200mg/weekX3 weeks initially. At the end of three weeks of starting therapy Hb estimation was done and compared with the baseline levels as regarding the hemoglobin rise. The results were statistically analyzed using the "paired t" test. Results: The requirement of iron-sucrose for the individual patient was calculated based on the weight of the patient. The analysis of iron requirement-sucrose combination showed a mean of 481.7 mg with standard deviation (SD) of 62.72 mg and a range of 378.85 mg. The minimum iron-sucrose requirement was 361.55 mg and the maximum was 740.40 mg The mean Hb (gm%) value before intervention was 8.43 with a standard deviation of 0.56, whereas, the mean Hb (gm %) value after intervention was higher, 10.41 with standard deviation (SD) of .56 the mean Hb (gm %) Increase in 2 weeks was 1.60 with standard deviation (SD) of 0.31, whereas, in 3 weeks was 2.03 with standard deviation (SD) of 0.51. The mean Hb (gm %) increase was higher in participants with 3 weeks, which was statistically significant (p<0.05). Conclusions: Parenteral iron therapy was not safe in the past but iron sucrose has made it the safest and effective therapy. Parenteral iron therapy can be used for patients with Hb level between 6-8mg/dl It is highly efficacious and reliable way to achieve the desired Hb level patient compliance is assured with intravenous iron sucrose patient can be satisfactorily posted for surgery within a period of 3 weeks i.e. within her next menstrual period by reliably and effectively correcting her anemia with intravenous iron sucrose.

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Section: Discussionmentioning

confidence: 99%

Intravenous iron sucrose for treatment of anemia in gynecology patients awaiting surgery

Gandhi

Satia

2016

Int J Reprod Contracept Obstet Gynecol

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“…15 In our study, minor adverse events were recorded in twenty-six patients which are similar to observations made by others. 9 Only four patients had more than five minor adverse events, while eighteen patients had up to four minor adverse events. Though there have been increase in the tolerable minor side effects only one patient reported moderate intensity adverse event in the form of urticaria and patient refused to continue iron therapy.…”

mentioning

confidence: 92%

“…Iron dextran has been associated with fatal anaphylactic reactions. 8 Fatal anaphylactic reactions are rarely reported with iron sucrose, but it is to be given in the form of 5 doses of 200 mg each over 14 days' period to achieve a cumulative dose of 1000 mg. 9,10 In such condition, multiple doses of iron sucrose over a prolonged period of time have to be given to achieve desired therapeutic effect which leads to multiple hospital visits and chances of drop-out rate increases. To overcome this an accelerated iron sucrose dosing regimen utilizing 500 mg of iron sucrose on daily basis has been given in patients of IDA with chronic kidney disease (CKD), inflammatory bowel disease (IBD) and pregnancy.…”

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confidence: 99%

Efficacy and safety of high dose accelerated intravenous iron sucrose in patients of iron deficiency anemia

et al. 2017

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Background: Low dose (200 mg) extended Intravenous iron sucrose remains the most common treatment option in patients who are intolerant to oral iron therapy in patients with Iron deficiency anemia (IDA). The objective of this study was to evaluate the efficacy and safety of high dose accelerated intravenous iron sucrose (IS) in the treatment of adults with iron deficiency anemiaMethods: One hundred adult patients with iron deficiency anemia, who had intolerance or showed no effect with oral iron therapy, received daily doses of 500 mg of intravenous iron sucrose until the hemoglobin level was corrected or until receiving the total dose of intravenous iron calculated for each patient.Results: The mean and median Hb (g/dL) 6.47±1.656 and 6.6 (2) at baseline, 9.61±1.629 and 9.6 (2) at 2 weeks of treatment, 11.85±1.277 and 12 (1) at 4 weeks of treatment respectively. The mean rise of Hb was 3.13±1.41 and 5.37±1.50 after 2 and 4 weeks of treatment respectively (p<0.000). A total of 303 intravenous infusions of iron sucrose were administered and iron sucrose was generally well tolerated with twenty-six patients developing mild and one patient developing moderate adverse drug reactions. There was no serious adverse event recorded.Conclusions: Accelerated high dose intravenous iron sucrose is a safe and cost effective option minimizing frequent hospital visits in the treatment of adults with iron deficiency anemia who are intolerant or lack satisfactory response to oral iron therapy.

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“…Os riscos mais evidenciados que envolvem o processo de administração de medicamentos por meio da via IM são: dor persistente no local, endurecimento, diminuição da sensibilidade, dano tecidual (lesão de nervos), hematomas, abscessos, reações alérgicas, lesões de necrose tecidual, contratura de grupos musculares, fibrose e até perda de amplitude de movimentos articulares (6)(7) . Neste contexto, o processo de administração de medicamentos por meio da via IM na pediatria exige dos profissionais envolvidos conhecimentos sobre o preparo correto, visto que esses pacientes constituem um grupo vulnerável, possuindo características farmacocinéticas e farmacodinâmicas com modificações rápidas ao longo do desenvolvimento infantil (8)(9) .…”

Section: Introductionunclassified

Preparo De Medicamentos Administrados via Intramuscular Na Pediatria: Atuação Da Equipe De Enfermagem

Mota¹,

Brito²,

Souza³

et al. 2016

Cogitare Enferm.

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RESUMO: Objetivou-se avaliar a atuação da equipe de Enfermagem na organização do ambiente, no preparo e na diluição de medicamentos administrados por via intramuscular na pediatria. Estudo observacional, quantitativo, desenvolvido mediante 327 observações do preparo de medicamento intramuscular, no período de dezembro de 2014 a maio de 2015, em um hospital pediátrico, Fortaleza-Ceará. Para observações utilizou-se um checklist composto pelas etapas: organização do ambiente com quatro ações; preparo e diluição de medicamentos com 12 ações. Na organização do ambiente, alcançou-se desempenho satisfatório na ação organizar a bancada, com 231 (70,6%). A etapa de preparo e diluição do medicamento obteve desempenho satisfatório em seis ações: separar bolas de algodão com álcool e seca, com 252 (77%); escolher seringa compatível com o volume a ser administrado, com 264 (80,7%); selecionar adequadamente a agulha para aspiração, com 233 (71,2%), e a agulha para administração, com 320 (97,8%); trocar agulha depois do preparo, com 266 (81,3%); e reconstituir medicação em água destilada, com 327 (100% RESUMEN: Se objetivó evaluar la actuación del equipo de Enfermería en la organización del ámbito, la preparación y dilución de medicamentos de administración intramuscular en pediatría. Estudio observacional, desarrollado sobre 327 observaciones de preparación de medicamentos intramusculares, entre diciembre de 2014 y mayo de 2015 en un hospital pediátrico de Fortaleza-Ceará. Se utilizó en las observaciones un check-list integrado por las etapas: organización del ámbito, con cuatro acciones; preparación y dilución de medicamentos, con 12 acciones. En la organización del ámbito se alcanzó desempeño satisfactorio en acción de organización de mesada, con 231 (70,6%). La etapa de preparación y dilución del medicamento obtuvo desempeño satisfactorio en seis acciones: separar trozos de algodón con alcohol y secos, con 252 (77%); elegir jeringa compatible con volumen a administrar, con 264 (80,7%); selección adecuada de aguja para aspiración, con 320 (97,8%); cambiar aguja luego de preparación, con 266 (81,3%); y reconstitución de medicación con agua destilada, con 327 (100%). Así, fueron identificadas debilidades, como observar fecha de vencimiento del medicamento e identificar la medida preparada, que interfieren con la seguridad de administración de medicamentos en pediatría.

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Tratamento da anemia ferropriva com ferro por via parenteral

Cited by 12 publications

References 21 publications

Intravenous iron sucrose for treatment of anemia in gynecology patients awaiting surgery

Intravenous iron sucrose for treatment of anemia in gynecology patients awaiting surgery

Efficacy and safety of high dose accelerated intravenous iron sucrose in patients of iron deficiency anemia

Preparo De Medicamentos Administrados via Intramuscular Na Pediatria: Atuação Da Equipe De Enfermagem

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