Trauma: o avesso da memória

Moreno, Maria Manuela Assunção

doi:10.11606/d.47.2009.tde-10022010-073843

Cited by 3 publications

(3 citation statements)

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“…The dose applied in our in vivo studies (1.12 g/kg) were about ten times less than the reported oral LD 50 in mice (>13.36 g/kg) (Hoffman-LaRoche, 1967). The oral LD 50 in rats have also been reported to be >5 g/kg (Moreno, 1974), indicating that the doses we used are within the sub-toxic range. Nonetheless, it may be possible to alter the dosing regimen such that the concentration of bisabolene administered is reduced but compensated by a higher frequency of doses.…”

Section: Discussionmentioning

confidence: 80%

β‐Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines

Yeo

Ali

Hayward

et al. 2015

Phytotherapy Research

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The essential oils from Commiphora species have for centuries been recognized to possess medicinal properties. Here, we performed gas chromatography-mass spectrometry on the essential oil from opoponax (Commiphora guidotti) and identified bisabolene isomers as the main constituents of this essential oil. Opoponax essential oil, a chemical component; β-bisabolene and an alcoholic analogue, α-bisabolol, were tested for their ability to selectively kill breast cancer cells. Only β-bisabolene, a sesquiterpene constituting 5% of the essential oil, exhibited selective cytotoxic activity for mouse cells (IC50 in normal Eph4: >200 µg/ml, MG1361: 65.49 µg/ml, 4T1: 48.99 µg/ml) and human breast cancer cells (IC50 in normal MCF-10A: 114.3 µg/ml, MCF-7: 66.91 µg/ml, MDA-MB-231: 98.39 µg/ml, SKBR3: 70.62 µg/ml and BT474: 74.3 µg/ml). This loss of viability was because of the induction of apoptosis as shown by Annexin V-propidium iodide and caspase-3/7 activity assay. β-bisabolene was also effective in reducing the growth of transplanted 4T1 mammary tumours in vivo (37.5% reduction in volume by endpoint). In summary, we have identified an anti-cancer agent from the essential oil of opoponax that exhibits specific cytotoxicity to both human and murine mammary tumour cells in vitro and in vivo, and this warrants further investigation into the use of β-bisabolene in the treatment of breast cancers.

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Section: Discussionmentioning

confidence: 80%

β‐Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines

Yeo

Ali

Hayward

et al. 2015

Phytotherapy Research

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“…On the other hand, people who suffer sexual trauma often do not report it or even do not remember it, possibly because recalling these events would threaten psychic balance and lead to psychological distress 38,39 . Furthermore, the influence of maternal depression on the emotional development of the child in adulthood is best evaluated through longitudinal studies.…”

Section: Discussionmentioning

confidence: 99%

Relationship between maternal depression as a risk factor for childhood trauma and mood disorders in young adults

Barbosa¹,

Quevedo²,

Silva³

et al. 2014

Rev. psiquiatr. clín.

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Background: Maternal depression may be a risk factor for childhood trauma (CT), with resultant offspring development of mood disorders (MD) in adult life. Objective: To verify the relationship between maternal depression (as a risk factor for childhood trauma) and mood disorders in young adults. Methods: The sample was composed of 164 young adults and their mothers. Maternal depression was identified through the Mini International Neuropsychiatric Interview (M.I.N.I.). Mood Disorders in the young adults were confirmed with the Structured Interview for the DSM-IV (SCID), whereas the CT was evaluated using the Childhood Trauma Questionnaire (CTQ). Results: In the group of young adults with MD, individuals who had depressed mothers presented higher mean scores of CT in comparison to the ones who did not have mothers with Depression (p < 0.005). Childhood trauma was also associated with lower social classes (p < 0.005). In the group of young adults without MD, the only variable that was associated with CT was the young adult's (not) current work (p < 0.005). Discussion: Maternal depression was considered to be a risk factor for CT and MD in young adults. Thus, preventing and treating maternal psychiatric disorders may diminish the risk of offspring childhood trauma, and, consequently, avoid negative effects in the offspring's adult life.

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“…Seguindo a ideia que temos apresentado a respeito da dimensão traumática evocada no encontro da criança com a violência, Éric Laurent (2014) nos ensina que é preciso pensar no trauma sob a lógica de dois lugares: o furo do real no simbólico e o avesso, o furo do simbólico no real. Compreendemos ser importante considerar essas duas dimensões do trauma, uma vez que é a partir do traumático -e não da eliminação do trauma -que, inevitavelmente, novas respostas poderão ser construídas pela criança, conforme nos diz Laurent (2014).…”

Section: Considerações Finais: Que Saída?unclassified

Traumatismo e violência: a criança em meio à guerra urbana brasileira

Souza,

Marcos

2023

Estilos Clín. (Online)

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O cotidiano de muitas crianças no Brasil tem sido atravessado por situações violentas extremas, evidenciando um estado de abandono social. Sendo assim, o presente artigo visa compreender, a partir da história de Sandro Barbosa do Nascimento e da psicanálise, a natureza do traumatismo e sua relação ao trauma na experiência da criança que vivencia cenas violentas em seu cotidiano. Compreendemos que o traumatismo se constitui na dimensão singular de cada criança, a partir do modo como lidam com o encontro com o trauma que as cenas violentas comportam, bem como com o gozo que irrompe da proximidade do Outro totalitário. Estes modos podem se constituir do recurso simbólico de cada sujeito, mas também da experiência com o não-sentido.

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Trauma: o avesso da memória

Cited by 3 publications

References 0 publications

β‐Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines

β‐Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines

Relationship between maternal depression as a risk factor for childhood trauma and mood disorders in young adults

Traumatismo e violência: a criança em meio à guerra urbana brasileira

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