Traumatic Brain Injury, Apolipoprotein E-ϵ4, and Cognition in Older Adults: A Two-Year Longitudinal Study

Rapoport, Mark J.; Wolf, Uri; Herrmann, Nathan; Kiss, Alex; Shammi, Prathiba; Reis, Marciano D.; Phillips, Andrea; Feinstein, Anthony

doi:10.1176/jnp.2008.20.1.68

Cited by 31 publications

(12 citation statements)

References 31 publications

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“…However, the details of how TBI associates with the onset of cognitive impairment is still unclear due to a number of factors such as varied criteria for defining TBI severity [2], as well as various types and severity of cognitive impairment. A history of TBI has been found to correlate with an elevated risk for developing cognitive impairment [3–7]. For example, a 5-year follow-up study found that TBI could increase the risk of developing dementia by 1.7 fold after adjusting for covariates [8].…”

Section: Introductionmentioning

confidence: 99%

Traumatic brain injury and age at onset of cognitive impairment in older adults

Risacher

McAllister

et al. 2016

J Neurol

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There is a deficiency of knowledge regarding how traumatic brain injury (TBI) is associated with age at onset (AAO) of cognitive impairment in older adults. Participants with a TBI history were identified from the Alzheimer’s disease neuroimaging initiative (ADNI 1/GO/2) medical history database. Using an analysis of covariance (ANCOVA) model, the AAO was compared between those with and without TBI, and potential confounding factors were controlled. The AAO was also compared between those with mild TBI (mTBI) and moderate or severe TBI (sTBI). Lastly, the effects of mTBI were analyzed on the AAO of participants with clinical diagnoses of either mild cognitive impairment (MCI) or Alzheimer’s disease (AD). The AAO for a TBI group was 68.2 ± 1.1 years [95 % confidence interval (CI) 66.2–70.3, n = 62], which was significantly earlier than the AAO for the non-TBI group of 70.9 ± 0.2 years (95 % CI 70.5–71.4, n = 1197) (p = 0.013). Participants with mTBI history showed an AAO of 68.5 ± 1.1 years (n = 56), which was significantly earlier than the AAO for the non-TBI group (p = 0.032). Participants with both MCI and mTBI showed an AAO of 66.5 ± 1.3 years (95 % CI 63.9–69.1, n = 45), compared to 70.6 ± 0.3 years for the non-TBI MCI group (95 % CI 70.1–71.1, n = 935) (p = 0.016). As a conclusion, a history of TBI may accelerate the AAO of cognitive impairment by two or more years. These results were consistent with reports of TBI as a significant risk factor for cognitive decline in older adults, and TBI is associated with an earlier AAO found in patients with MCI or AD.

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Section: Introductionmentioning

confidence: 99%

Traumatic brain injury and age at onset of cognitive impairment in older adults

Risacher

McAllister

et al. 2016

J Neurol

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“…Lastly, many studies reporting a lack of association between TBI and dementia have relied upon self-report 1,2,33 (raising concern for recall bias), have used a report of “head injury” 3–5 to approximate a history of TBI (raising concern for misdiagnosis), or have provided insufficient longitudinal follow-up. 2,14 …”

Section: Discussionmentioning

confidence: 99%

“…13 Even among studies reporting a positive association between TBI and dementia, there is dramatic variability in the magnitude of reported risk, which may be due to differences in TBI severity, age of subjects, and follow-up period (with some being as short as two years) between studies. 2,14 …”

Section: Introductionmentioning

confidence: 99%

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma

et al. 2014

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“…At a system level, diffuse axonal injury may lead to increased vulnerability to N-methyl-D-aspartate toxicity (Arundine et al, 2004;Wolf et al, 2001), but brain injury severity may not be related to the apolipoprotein E-4 allele (Rapoport et al, 2008). In microdialysis studies of four TBI patients who had catheters in the area of the cranial bone flap and in the frontal lobe, the lesion site had higher FDG-PET metabolic rates and higher lactate and pyruvate than the frontal lobe site (Hutchinson et al, 2009).…”

Section: Regional Effectsmentioning

confidence: 98%

Statistical Parametric Mapping and Cluster Counting Analysis of [¹⁸F] FDG-PET Imaging in Traumatic Brain Injury

Zhang

Mitsis

Chu

et al. 2010

Journal of Neurotrauma

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In this study we investigated regional cerebral glucose metabolism abnormalities of [(18)F] fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in traumatic brain injury (TBI). PET images of 81 TBI patients and 68 normal controls were acquired and a word list learning task was administered during the uptake period. The TBI group included 35 patients with positive structural imaging (CT or MRI) findings soon after injury, 40 patients with negative findings, and 6 cases without structural imaging. Statistical parametric mapping (SPM) analysis was applied with several levels of spatial smoothing. Cluster counting analysis was performed for each subject to identify abnormal clusters with contiguous voxel values that deviated by two standard deviations or more from the mean of the normal controls, and to count the number of clusters in 10 size categories. SPM maps demonstrated that the 81 patients had significantly lower FDG uptake than normal controls, widely across the cortex (including bilateral frontal and temporal regions), and in the thalamus. Cluster counting results indicated that TBI patients had a higher proportion of larger clusters than controls. These large low-FDG-uptake clusters of the TBI patients were closer to the brain edge than those of controls. These results suggest that deficits of cerebral metabolism in TBI are spread over multiple brain areas, that they are closer to the cortical surface than clusters in controls, and that group spatial patterns of abnormal cerebral metabolism may be similar in TBI patients with cognitive deficits with and without obvious acute abnormalities identified on structural imaging.

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Traumatic Brain Injury, Apolipoprotein E-ϵ4, and Cognition in Older Adults: A Two-Year Longitudinal Study

Cited by 31 publications

References 31 publications

Traumatic brain injury and age at onset of cognitive impairment in older adults

Traumatic brain injury and age at onset of cognitive impairment in older adults

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma

Statistical Parametric Mapping and Cluster Counting Analysis of [¹⁸F] FDG-PET Imaging in Traumatic Brain Injury

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Traumatic Brain Injury, Apolipoprotein E-ϵ4, and Cognition in Older Adults: A Two-Year Longitudinal Study

Cited by 31 publications

References 31 publications

Traumatic brain injury and age at onset of cognitive impairment in older adults

Traumatic brain injury and age at onset of cognitive impairment in older adults

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma

Statistical Parametric Mapping and Cluster Counting Analysis of [18F] FDG-PET Imaging in Traumatic Brain Injury

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Product

Resources

About

Statistical Parametric Mapping and Cluster Counting Analysis of [¹⁸F] FDG-PET Imaging in Traumatic Brain Injury