2011
DOI: 10.1590/s0102-86502011000200004
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Traumatic brain injury: clinical and pathological parameters in an experimental weightdrop model

Abstract: The experimental cranium trauma animal model by weight drop is an alternative of low cost and easy reproduction that allows evaluating clinical and pathological alterations in accordance with studies in experimental surgery aims for new traumatic brain injury approach in rats.

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Cited by 9 publications
(5 citation statements)
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“…For the weight-drop model, this model is limited in the production of primary lesions that are macroscopically meaningful once it is not capable of creating cranial fractures with levels of energy compatible with life after impact. It presented discrete focal lesions in a small number of animals and only at elevated levels of energy, but in accordance with what was described in similar studies [ 59 ]. Moreover, any single animal model may not be able to fully mimic the highly heterogeneous nature of human TBI [ 60 ].…”
Section: Discussionsupporting
confidence: 91%
“…For the weight-drop model, this model is limited in the production of primary lesions that are macroscopically meaningful once it is not capable of creating cranial fractures with levels of energy compatible with life after impact. It presented discrete focal lesions in a small number of animals and only at elevated levels of energy, but in accordance with what was described in similar studies [ 59 ]. Moreover, any single animal model may not be able to fully mimic the highly heterogeneous nature of human TBI [ 60 ].…”
Section: Discussionsupporting
confidence: 91%
“…The force to be applied to the head was determined not to exceed 0.5 joules so that the animals would survive the head injury and maintain their nourishment functions. For this purpose, we used weight and height upper limits of 50 g and 1 m, respectively [9].…”
Section: Methodsmentioning
confidence: 99%
“…In order to mimic human diffuse TBI caused by falls or motor vehicle accidents, we used the Marmarou’s impact acceleration model (Marmarou´s IAM) that recreates global impact on the brain ( Foda and Marmarou, 1994 ; Marmarou et al, 1994 ; Silva et al, 2011 ; Xiong et al, 2013 ). For this purpose, animals were anesthetized (Ketamine 55 mg/kg/xylazine 11 mg/kg) and subjected to a controlled TBI, described elsewhere ( Marmarou et al, 1994 ; Silva et al, 2011 ). Briefly, the “trauma device” consists of 1 m removable aluminum tube, attached to a wooden platform, which allows a controlled impact when dropping a 45 gr brass sphere onto a stainless steel disc located above the animal head, causing a 0.45J impact when it is dropped from the mentioned height.…”
Section: Methodsmentioning
confidence: 99%