Travel-acquired Japanese encephalitis and vaccination considerations

Pavli, Androula; Maltezou, Helena C.

doi:10.3855/jidc.5108

Cited by 16 publications

(10 citation statements)

References 36 publications

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“…Various reasons such as climate change ( i. e . elevated temperature), soil humidity and change in vegetation, are also contributing factors towards changes in the composition and density of sand fly species, populations of rodents and finally the increased incidence rate of leishmaniasis worldwide . Therefore, search for effective antileishmanial agents is critically important to control the epidemic of such infectious diseases.…”

Section: Resultsmentioning

confidence: 99%

Gold‐NHC complexes as potent bioactive compounds

et al. 2016

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This report describes the evaluation of the biological activities of 13 gold‐NHC complexes. These complexes were evaluated in vitro for their antioxidant properties, α‐glucosidase, thymidine phosphorylase, β‐glucuronidase and xanthine oxidase enzyme inhibition activities. Among the tested complexes, those bearing chloride ligands were found to be potent antioxidant, α‐glucosidase, thymidine phosphorylase, β‐glucuronidase and xanthine oxidase enzyme inhibitors, showing several hundred fold higher activity than the standard drugs. Some of these complexes were found to be potent antileishmanial agents, which were superior to standard antileishmanil drugs. These gold complexes were also evaluated for their in vitro cytotoxic activity against PC‐3 (normal cells), HeLa (cervical cancer), MCF‐3 (breast cancer) and 3T3 (mouse fibroblast) cell lines.

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Section: Resultsmentioning

confidence: 99%

Gold‐NHC complexes as potent bioactive compounds

et al. 2016

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“…The estimated risk for travelers is considered very low (< 1 per million people traveling from non-endemic countries to Asia). Cases among travelers are correlated with long stay (≥ 1 month), rural area visits, and spending time under very basic conditions; thus, immunization for JE is generally recommended [28][29][30] . There are four vaccines available for JE.…”

Section: Japanese Encephalitismentioning

confidence: 99%

Preventing diseases in round-the-world travelers: a contemporary challenge for travel medicine advice

Rodrigues

Moreira

2018

Rev. Soc. Bras. Med. Trop.

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Providing advice for travelers embarking on long-term trips poses a challenge in travel medicine. A long duration of risk exposure is associated with underuse of protective measures and poor adherence to chemoprophylaxis, increasing the chances of acquiring infections. Recently, in our clinic, we observed an increase in the number of travelers undertaking round-the-world trips. These individuals are typically aged around 32 years and quit their jobs to embark on one-to-two-year journeys. Their destinations include countries in two or more continents, invariably Southeast Asia and Indonesia, and mostly involve land travel and visiting rural areas. Such trips involve flexible plans, increasing the challenge, especially with regard to malaria prophylaxis. Advising round-the-world travelers is time-consuming because of the amount of information that must be provided to the traveler. Advisors must develop strategies to commit the traveler to his/her own health, and verify their learnings on disease-prevention measures. Contacting the advisor after the appointment or during the trip can be helpful to clarify unclear instructions or diagnosis made and prescriptions given abroad. Infectious diseases are among the most frequent problems affecting travelers, many of which are preventable by vaccines, medicines, and precautionary measures. The dissemination of counterfeit medicines, particularly antibiotics and antimalarial medicines, emphasizes the need for travelers to carry medicines that they may possibly need on their trip. Additional advice on altitude, scuba diving, and other possible risks may also be given. Considering the difficulties in advising this group, we present a review of the main recommendations on advising these travelers.

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“…The occurrence of leishmaniasis has worsened with the emergence of the HIV/ Leishmania co‐infection and with the development of drug‐resistance by parasites. An increase in the incidents of leishmaniasis can be associated with environmental changes, populations of rodents and finally the increased worldwide incidence rate of leishmaniasis . One of the main strategies to combat this phenomenon and to discover new therapeutic leads is to investigate new classes of potentially bioactive compounds.…”

Section: Figurementioning

confidence: 99%

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

et al. 2017

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The aim of this research is to evaluate for the first time the in vitro leishmanicidal activity and inhibition of a-glucosidase and b-glucuronidase of new gold(I) and gold(III) complexes involving N-heterocyclic carbene (NHC) ligands, with the general formula [Au(X) n (NHC)R 2 ][BF 4 ] (X=Cl, OAc, R = various aromatic and aliphatic substituents). The Au(III) complexes were shown to have a significant antileishmanial activity, and were also found to be more potent inhibitors of a-glucosidase and b-glucuronidase enzymes than the standard drugs. Some complexes were also identified as potent anti-inflammatory agents with activity comparable to that of tested standard drugs, allopurinol and ibuprofen. These gold complexes were also evaluated for their in vitro cytotoxic activity against HeLa (cervical cancer), MCF-3 (breast cancer), and 3T3 (mouse fibroblast) cell lines.Recent advancements in transition-metal-based compounds have found wide medical applications. The use of cisplatin to treat ovarian cancer and the discovery of the gold-based drug auranofin to treat rheumatoid arthritis are among the numerous examples that have seen transition metal complexes combat human ailments. Nowadays, large libraries of platinum-, palladium-, ruthenium-and gold-containing molecules are being synthesized for therapeutic purposes. [1][2][3]

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Travel-acquired Japanese encephalitis and vaccination considerations

Cited by 16 publications

References 36 publications

Gold‐NHC complexes as potent bioactive compounds

Gold‐NHC complexes as potent bioactive compounds

Preventing diseases in round-the-world travelers: a contemporary challenge for travel medicine advice

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

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