Treadmill exercise enhances ABCA1 expression in rat liver

Ghanbari–Niaki, Abbass; Khabazian, Behzad Mehdi; Hossaini-Kakhak, Seyed Alireza; Rahbarizadeh, Fatemeh; Hedayati, Mehdi

doi:10.1016/j.bbrc.2007.07.100

Cited by 61 publications

(53 citation statements)

References 44 publications

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“…The main findings of Hoang et al were that leukocyte ABCA1 expression relates positively with frequency of exercise and muscle ABCA1 expression relates positively with alcohol consumption [20]. Khabazian et al reported that six week of endurance training increased Liver and intestine ABCA1 mRNA expression significantly higher in trained rats compared to control rats [9,18]. In the present study, we investigate lymphocyte ABCA1 gene expression in human and use specific eight weeks training protocol that may be more accurate than questionnaire or acute exercise.…”

Section: Discussionmentioning

confidence: 99%

Effect of Eight Weeks of Wrestling and Circuit Fitness Training on APO Lipoprotein A-I and Lymphocyte ABCA1 Gene Expression in Well-Trained Wrestlers

Rashidlamir

Saadatnia

Ebrahimi-Atri

et al. 2011

International Journal of Wrestling Science

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ABSTRACT:Introduction: Atherosclerotic cardiovascular disease is now the leading cause of death in most countries. The ABCA1 gene provides instructions for the production of proteins (ATP-binding transporter protein) whose function is to export phospholipid and cholesterol out of the cells where they are bound to circulating apolipoprotein A1 (apoA1) and removed in the liver. Increased ABCA1 activity could inhibit atherosclerosis. In the present study, ABCA1 gene expression in lymphocytes and the associated effect of exercise were studied. Method: Subjects were 16 well-trained wrestlers randomly assigned into experimental and control groups. The experimental group performed 8 weeks of wrestling and circuit fitness training and the control group remained sedentary. Blood samples were collected 48 hours before the first session and 48 hours after the last session (subjects were fasting). After isolating lymphocytes by centrifugation, ABCA1 gene expression in lymphocytes was measured using semi-quantitative-RT-PCR. Data analyzed by SPSS software (version 16). Results: a significant increase in lymphocyte ABCA1 gene expression was shown following the 8 weeks of training (experimental p<0.001, t=-9.954). Plasma HDL-C concentrations and Apo A-I increased (P<0.001, t=4.97 P<0.05, t=2.67 respectively) and plasma LDL-C concentration decreased (P<0.001, t=4.35) in experimental group when compared with the control group. Discussion and Conclusion: Anaerobic exercises like wrestling and circuit fitness training can increase ABCA1 gene expression, an effective factor in the prevention of cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Effect of Eight Weeks of Wrestling and Circuit Fitness Training on APO Lipoprotein A-I and Lymphocyte ABCA1 Gene Expression in Well-Trained Wrestlers

Rashidlamir

Saadatnia

Ebrahimi-Atri

et al. 2011

International Journal of Wrestling Science

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“…It should be noted that this is the first study to determine the effects of training program with Sorkh valik extract on ABCA1, ABCG1, LXR and PPAR-α mRNA expression in rat heart. Considering ABCA1, Ghanbari-Niaki et al reported a higher and significant level of ABCA1 mRNA expression in rat liver after 12 weeks of endurance (25 m/min, 90 min/ day) exercise training [3]. A higher and significant ABCA1 mRNA expression in rat heart and small intestine tissues were also reported by Khabazian et al [17] and GhanbariNiaki [4] who employed the same treadmill running program but short duration (60 min/day).…”

Section: Discussionmentioning

confidence: 56%

“…The animals were familiarized with animal room, treadmill apparatus for 10 days. The exercise groups were trained on a motor driven treadmill for 8 weeks according to the previously reported elsewhere [3]. The rats were submitted to run at low intensity [15 m/min, for 20 min] and then speeds and duration gradually were increased and at the first of third week rats were able to run at 34 m/min for 60 minutes, 5 days/week [13].…”

Section: Methodsmentioning

confidence: 99%

“…The responses of ATP-binding cassette protein transporters A and G families members, particularly, ABCA1 and ABCG1 to different types of physical exercise in human and animal has also been investigated by several researchers [3][4][5][6]. ABCA1 is a multispan molecule with high expression level in the heart and other tissues and up-regulated by several factors such as cholesterol influx and physical activity [5].…”

Section: Introductionmentioning

confidence: 99%

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Heart ATP-Binding Cassette protein A1 and G1, Peroxisome Proliferator-Activated Receptor-α and Liver X Receptors Genes Expression in Response to Intensive Treadmill Running and Red Crataegus pentaegyna (Sorkh valik) in Male Rats

Ghanbari–Niaki

Abarghooi

Gholizadeh

2015

Zahedan J Res Med Sci

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Background:The heart has a very high energy demand and to sustain sufficient ATP generation, can use a variety of different carbon substrates as energy sources if available. Objectives:The purpose of the current study was to investigate the effect of a high intensity treadmill running training (8 weeks) with or without aqueous extraction of Crataegus pentaegyna (Sorkh valik) on heart ABCA1, ABCG1, PPARα and LXR genes expression. Materials and Methods:In this experimental study, 20 Wistar male rats (4-6 weeks old, 158.9 ± 9.59 g weight) were used. Animals were randomly assigned into saline-control (SC, n = 5), saline-training (ST, n = 5), Sorkh valik-control (SVC, n = 5) and Sorkh valik-training (SVT, n = 5) groups. Training groups have performed a high intensity running program 34 m/min on a motor-driven treadmill for 8 weeks. Animals were fed orally with Sorkh valik extraction (500 mg/kg) and saline solution for last 6 weeks. Seventy two hours after the last training session, rats were sacrificed, heart were excised, cleaned and immediately frozen in liquid nitrogen and stored at -70°C until RNA extraction. Statistical analysis was performed using a two way ANOVA, and significance was accepted at P < 0.05. Results: Changes in ABCA1 and ABCG1 gene expression were not significant and a non-significant increase in PPAR-α and LXR genes expression were found in the trained rats and Sorkh valik-control group than in the control group. Conclusions: The findings indicate that training and Sorkh valik extraction solely were able to increase non-significantly all selected genes expression in rat heart. It seems that exercise with Sorkh valik supplementation trend to decrease mentioned genes expression.

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“…Using the training methods previously described, the exercise group was trained for 8 weeks [52,53]. Running at 25 m/min for 60 minutes, 5 d/wk, the rats were scarified 72 hours after the last session of exercises.…”

Section: Exercise Training Protocolmentioning

confidence: 99%

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

Shirvani¹,

Ghanbari–Niaki²,

Rahmati-Ahmadabad

et al. 2017

Int J Appl Exerc Physiol

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ABSTRACT:The aim of present study was to investigate the effects of aerobic training with and without Pistacia-atlantica (Bane) extraction as a plant rich in fatty acids, on rat tissues nesfatin-1/nucleobindin-2 and ghrelin gene expression and also on plasma lipid and lipoproteins profiles.Twenty healthy and intact Wistar rats were obtain and randomly were assigned into saline-control (SC), saline-training (ST), Bane-control (BC), and Bane-training (BT) groups. Training groups ran on a motor driven treadmill (at intensity 25m/min, 5days/wk.) for 8 weeks. Rats were orally received saline or bene solution (100 mg/kg and 7.5ul/g of body weight). Blood was collected to determine biochemical variables and liver and visceral fat were also obtain for Nesfatin-1/nucleobindin-2 and ghrelin mRNA expressions by using a Real-time PCR technique.A higher and significant nesfatin-1 mRNA expressions in liver and visceral fat and liver estradiol were observed in trained groups. However, the level of ghrelin expression was lower in trained groups when compared to control rats. In general, lower tissues nesfatin-1mRNA expression and lower plasma and higher estradiol HDL-C were observed in bane-treated rats. A negative and positive correlation between liver estradiol and liver ghrelin expression, plasma estradiol, HDL-C and visceral fat nesfatin-1 expression were found respectively. The results of present study indicate that exercise combined with bane-treatment induced considerable changes on liver and visceral fat nesfatin-1 and ghrelin expression which was accompanied with a significant change in plasma HDL-C as a cardiovascular risk factor.

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Treadmill exercise enhances ABCA1 expression in rat liver

Cited by 61 publications

References 44 publications

Effect of Eight Weeks of Wrestling and Circuit Fitness Training on APO Lipoprotein A-I and Lymphocyte ABCA1 Gene Expression in Well-Trained Wrestlers

Effect of Eight Weeks of Wrestling and Circuit Fitness Training on APO Lipoprotein A-I and Lymphocyte ABCA1 Gene Expression in Well-Trained Wrestlers

Heart ATP-Binding Cassette protein A1 and G1, Peroxisome Proliferator-Activated Receptor-α and Liver X Receptors Genes Expression in Response to Intensive Treadmill Running and Red Crataegus pentaegyna (Sorkh valik) in Male Rats

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

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