Treadmill Running Reduces Parathyroid Hormone Concentrations During Recovery Compared With a Nonexercising Control Group

Scott, Jonathan; Sale, Craig; Greeves, Julie P.; Casey, Albert E.; Dutton, John; Fraser, William D.

doi:10.1210/jc.2013-3027

Cited by 26 publications

(12 citation statements)

References 43 publications

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“…In the study by Li et al (2014), blood estradiol concentration increased significantly in ovariectomized rats after treatment using voluntary wheel running exercise, and such changes in concentration was attributed to the appropriate exercise intensity 32 . These results supported the findings by Kim (2012) and Scott et al (2014) on moderate-intensity aerobic exercise using a treadmill 30 , 33 and Stringhetta-Garcia et al (2016) on resistance exercise showed that the serum estradiol levels were decreased or similar compared to the levels of control group (ovariectomized) 34 . Therefore, it is believed that additional studies in accordance with the exercise intensity are needed to accurately identify factors that impact lipid and bone metabolism and changes in the blood estradiol concentration based on exercise after ovariectomy.…”

Section: Discussionsupporting

confidence: 88%

The effects of downhill and uphill exercise training on osteogenesis-related factors in ovariectomy-induced bone loss

Kang

Kim

2017

JENB

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[Purpose]Recent evidence suggests that regular exercise training plays a decisive role in maintaining homeostasis and promoting muscle and skeletal formation. However, the effect of downhill exercise training on osteogenesis-related factors is not well understood.[Methods]Thus, we investigated the effect of uphill and downhill training on ovariectomy (OVX)-induced bone loss. After ovary removal, the exercise method performed included uphill (16 m/min, +15°) and downhill training (16 m/min, –15°) for 60 min/day and 5 days/week, respectively, for 8 weeks.[Results]Our results showed that both uphill and downhill training significantly decreased the body weight, total cholesterol, and creatine kinase (CK) levels in the context of OVX-induced bone loss. On the contrary, levels of an osteogenesis indicator, osteocalcin and alkaline phosphatase were elevated. Consequently, the uphill and downhill training reduced OVX- induced bone loss in the distal femoral metaphysis. Likewise, the bone microstructure in OVX-induced bone loss was enhanced upon training. In particular, the inhibition of RANKL-induced osteoclast formation and osteoclast-specific gene expression improved upon downhill training compared to uphill training.[Conclusion]These results suggest that the uphill and downhill exercise types appeared to positively affect the expression of osteogenesis-related factors along with bone density and microstructure. Particularly, the downhill training has more beneficial effects on the maintenance of homeostasis during bone formation.

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Section: Discussionsupporting

confidence: 88%

The effects of downhill and uphill exercise training on osteogenesis-related factors in ovariectomy-induced bone loss

Kang

Kim

2017

JENB

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“…In this regard, two days of exercise significantly increased serum Ca, phosphorus and Ca/phosphorus ratio levels in elderly mice, while no significant change in these markers was reported after 3 and 8 weeks of exercise, nevertheless in line with the present study, bone density and strength significantly increased after long-term exercise in 16-month-old mice (16). Researchers have shown that exercise modulates the parathyroid hormone levels, but has no significant effect on Ca and phosphorus in young men (18); also, combined endurance and strength trainings increased bone strength by reducing parathyroid hormone levels, reducing inflammatory cytokines, and increasing osteocalcin (19).…”

Section: Discussionsupporting

confidence: 87%

The Effect of High Intensity Interval Training with Genistein on Biomechanical Properties of Femur Bone in Elderly Female Rats

et al. 2020

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Background and objective: Proper exercise and nutrition can help prevent bone disorders in old age, therefore present study aimed to investigate the effects of high intensity interval training (HIIT) with genistein (Ge) on biomechanical properties of femur bone in elderly female rats. Methods: In this experimental study, 40 elderly female rats with mean age of 18-24 months and mean weight of 220.15±15.28 g were divided into five groups of eight rats including: 1) control (C), 2) sham (Sh), 3) HIIT, 4) HIIT + Ge, and 5) Ge. During eight weeks groups 3 and 4 performed HIIT for three sessions per week with an intensity of 90 to 95% of maximum oxygen consumption (VO2max) in high intensity intervals and 40 to 45% VO2max in low intensity intervals and groups 4 and 5 received 60 mg/kg/day Ge peritoneally. Maximum bending strength (Fmax) measured with three-point bending test and serum levels of calcium (Ca) and phosphorus were measured by o-Cresolphthalein and molybdate methods, respectively. Shapiro-Wilk, one way ANOVA with Tukey's posthoc tests were used for analysis of data (P≤0.05). Results: HIIT (P=0.02), Ge (P=0.001) and HIIT+Ge (P=0.001) significantly increased Fmax also Ge (P=0.04) and HIIT+Ge (P=0.03) had more favorable effect on increasing Fmax compare to HIIT nevertheless HIIT, Ge and HIIT+Ge had not significant effect on Ca and phosphorus (P≥0.05). Conclusion: Although HIIT and Ge alone can enhance Fmax in femur of elderly female rats, nevertheless HIIT+Ge has more favorable effect on increase of Fmax compare to HIIT.

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“…Although the mechanism is still unclear, an increased running distance may potentially influence increased PTH concentration. PTH concentration has been reported to be transient-increase dependent on exercise intensity and duration [ 20 , 21 ]. In addition, teriparatide (recombinant human PTH), a therapeutic osteoporosis drug, has been reported to decrease 25(OH)D concentration [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Ongoing Vitamin D and Low-Fat Milk Intake on Bone Metabolism in Female High-School Endurance Runners

et al. 2018

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BackgroundVitamin D and calcium are essential nutrients for bone health. In addition, vitamin D suppresses inflammatory cytokines and increases bone resorption. Therefore, improvements in bone health by calcium and vitamin D supplementation have the potential to not only improve calcium metabolism but also suppress inflammation associated with exercise training. The purpose of this study was to determine whether ongoing vitamin D supplementation and low-fat milk intake by female high-school endurance runners would improve bone metabolism by suppressing inflammatory cytokines and the parathyroid hormone (PTH).MethodsTwenty female high-school runners were assigned to a vitamin D supplement and low-fat milk intake group (MKD) or a control group (CON). Participants in the MKD group consumed a vitamin D supplement (1,000 IU/day) and low-fat milk (Ca 315 mg/day) for 6 months. Bone mineral density measurements, blood samples, and questionnaires (regarding menses and diet) were carried out. The UMIN Clinical Trials Registry number is UMIN000027854.ResultsThe 25-hydroxyvitamin D (25(OH)D) concentration in MKD was sustained and PTH concentration was decreased regardless of the state of menses. The correlation coefficients of 25(OH)D or PTH concentrations and bone metabolism markers were analyzed by partial correlation coefficient via adjusting the model for frequency of menses. CTX and 25(OH)D concentration were significantly and inversely correlated at baseline (r = -0.61, P < 0.01), 3 months (r = -0.54, P = 0.02), and 6 months (r = -0.53, P = 0.02). CTX and PTH were significantly and positively correlated at 3 months (r = 0.63, P < 0.01) and 6 months (r = 0.52, P = 0.02). The bone alkaline phosphatase (BAP)/CTX ratio and 25(OH)D concentration were significantly and positively correlated at 3 months (r = 0.59, P = 0.01) and 6 months (r = 0.56, P = 0.01). The BAP/CTX ratio and PTH were significantly and inversely correlated at 3 months (r = -0.59, P = 0.01) and 6 months (r = -0.58, P < 0.01).ConclusionsThis study suggested that vitamin D and low-fat milk supplementation improves bone metabolism by sustaining the 25(OH)D concentration and decreasing the PTH concentration in female high-school endurance runners regardless of the state of menses.

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Treadmill Running Reduces Parathyroid Hormone Concentrations During Recovery Compared With a Nonexercising Control Group

Abstract: Lower PTH concentrations after acute endurance running compared with a rested control condition suggest a true effect of exercise.

Cited by 26 publications

References 43 publications

The effects of downhill and uphill exercise training on osteogenesis-related factors in ovariectomy-induced bone loss

The effects of downhill and uphill exercise training on osteogenesis-related factors in ovariectomy-induced bone loss

The Effect of High Intensity Interval Training with Genistein on Biomechanical Properties of Femur Bone in Elderly Female Rats

The Effect of Ongoing Vitamin D and Low-Fat Milk Intake on Bone Metabolism in Female High-School Endurance Runners

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