Treating anxiety and depression in inflammatory bowel disease: a systematic review

Prendergast, Kathryn; Gowey, Marissa A.; Barnes, Margaux; Keller, Caroline V; Horne, Caitlin; Young, John

doi:10.1080/08870446.2020.1867135

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…27 Patients with IBD are on multiple medications and may often be resistant to pharmacological therapy, furthering the need for mindfulness techniques, relaxation, and cognitive reconstruction. 28 There are several limitations to this study. The study identified cohorts retrospectively and cannot determine causality.…”

Section: Discussionmentioning

confidence: 94%

Relation between inflammatory bowel disease, depression, and inpatient outcomes in the United States

Ali

Pamarthy

Bolick

et al. 2022

Baylor University Medical Center Proceedings

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The relationship between inflammatory bowel disease (IBD) and depression is complicated. The effect of depression on ulcerative colitis (UC) and Crohn's disease (CD) among the inpatient US population has not previously been studied. We retrospectively analyzed patients admitted with UC and CD from 2016 to 2019 using the National Inpatient Sample database. Our primary outcome was the effect of depression on hospital length of stay (LOS), costs, and mortality. Secondary outcomes included the comparison between UC and CD cases. In the UC population, 13.4% had depression, compared to 14.9% in the CD population. LOS was longer in UC and CD patients with depression (P < 0.001). Subgroup analysis revealed that LOS was longer in CD patients than UC patients in the depressed cohort (P < 0.001). Inpatient hospital costs were lower in IBD patients with depression (P < 0.001). Subgroup analysis revealed that hospital cost was $17,974 higher in CD patients than UC patients (P < 0.001). Depression did not increase mortality in the IBD population but increased LOS, with a greater impact on CD than UC. White women were found to have an increased prevalence of depression in the IBD population.

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Section: Discussionmentioning

confidence: 94%

Relation between inflammatory bowel disease, depression, and inpatient outcomes in the United States

Ali

Pamarthy

Bolick

et al. 2022

Baylor University Medical Center Proceedings

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“…The most common psychological issues related to UC are anxiety and depression. The chronic inflammation associated with UC makes patients prone to psychological issues owing to their early diagnosis and lifelong symptoms (Neuendorf et al, 2016 ; Prendergast et al, 2022 ). There is a high prevalence of anxiety and depression in patients with UC, with up to one-third of patients experiencing anxiety symptoms and a quarter experiencing depression (Yu et al, 2023 ); female gender, lack of social support, and disease activity were associated with depression and anxiety in UC (Mikocka-Walus et al, 2016 ; Neuendorf et al, 2016 ; Williet and Sarter, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The variation characteristics of fecal microbiota in remission UC patients with anxiety and depression

Xu,

Li,

2023

Front. Microbiol.

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BackgroundUlcerative colitis (UC) patients with relapsed disease are most likely to suffer from anxiety and depression. Increasing data indicates that psychological issues can change the composition of intestinal flora. Thus, we aim to seek the variation of intestinal microbiota composition in remission UC patients with anxiety and depression in Northwest China.ResultsIn this study, 45 UC patients in remission were enrolled. The incidence of anxiety was 33.3%, and the prevalence of depression was 22.2%. There was no statistical difference in the alpha diversity of fecal microbiota, while beta diversity had a significant difference between the anxiety group and the non-anxiety group and the depression group and the non-depression group. Species composition analysis results showed that the ratio of Bifidobacterium and Lactobacilales significantly decreased. At the same time, the proportion of Escherichia-Shigella and Proteus_mirabilis increased in the anxiety group, and the ratio of Faecalibacterium and Bifidobacterium significantly decreased. In contrast, Escherichia-Shigella increased in the depression group at the gene levels.ConclusionAnxiety and depression still exist in UC patients even in the remission period. We first identify that the proportion of probiotics decreases while the proportion of pathogens increases in UC patients with anxiety and depression. These findings may provide a new pathophysiological mechanism for the recurrence of disease caused by impaired psychological function and a new method for the treatment strategy of UC patients with psychological issues.

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Burden of depression and anxiety among patients with inflammatory bowel disease: results of a nationwide analysis

Tarar

Zafar

Farooq

et al. 2021

Int J Colorectal Dis

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Treating anxiety and depression in inflammatory bowel disease: a systematic review

Cited by 4 publications

References 31 publications

Relation between inflammatory bowel disease, depression, and inpatient outcomes in the United States

Relation between inflammatory bowel disease, depression, and inpatient outcomes in the United States

The variation characteristics of fecal microbiota in remission UC patients with anxiety and depression

Burden of depression and anxiety among patients with inflammatory bowel disease: results of a nationwide analysis

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