Treatment and outcome of maxillary sinusitis associated with maxillary medication-related osteonecrosis

Sawada, Shunsuke; Kojima, Yasuyuki; Yasui, Hiroki; Kirihigashi, Mako; Yun, Yasutaka; Hayashida, Shinsaku; Rokutanda, Satoshi; Soutome, Sakiko; Yanamoto, Souichi; Umeda, Masahiro; Iwai, Hiroshi

doi:10.1016/j.ajoms.2021.01.012

Cited by 5 publications

(3 citation statements)

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“…As described above, it has become common to recommend surgery as a treatment method for MRONJ. However, the majority of these reports were related to patients with MRONJ in the mandible, and few papers described in detail how to treat maxillary cases [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sawada reported that four patients with maxillary MRONJ with sinusitis achieved healing by resection of necrotic bone combined with ESS [ 10 ]. Park reported that ESS showed a higher percentage of resolution of MRONJ, as described above [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Okuyama et al reported that complete resection of necrotic bone is needed to achieve complete healing of maxillary MRONJ and that concomitant maxillary sinusitis tends to heal or improve clinically alongside the healing of maxillary MRONJ [ 9 ]. Sawada reported good results from simultaneously performing endoscopic sinus surgery (ESS) and necrotic bone resection [ 10 ]. However, their study had short follow-up cases and did not reveal the indications for ESS.…”

Section: Introductionmentioning

confidence: 99%

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Retrospective Analysis of Treatment Outcomes of Maxillary Sinusitis Associated with Medication-Related Osteonecrosis of the Jaw

Otsuru

Hayashida

Morishita

et al. 2022

IJERPH

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Although maxillary sinusitis often occurs in patients with medication-related osteonecrosis of the jaw (MRONJ) of the upper jaw, there have been few reports on the treatment and outcomes for maxillary sinusitis associated with maxillary MRONJ. This study aimed to retrospectively investigate the treatment outcomes of maxillary sinusitis in patients with MRONJ of the upper jaw. There were 34 patients diagnosed with maxillary MRONJ and sinusitis by preoperative computed tomography who underwent surgery in our institution between January 2011 and December 2019. Age, sex, primary disease, stage of MRONJ, class and administration period of an antiresorptive agent, corticosteroid administration, preoperative leukocyte count and serum albumin level, periosteal reaction, sinusitis grade, maxillary sinus surgical procedure, and treatment outcomes of MRONJ and sinusitis were examined. There were 7 male and 27 female patients (average age, 74.7 years). Complete healing of MRONJ was obtained in 29 of 34 patients (85.3%). Maxillary sinusitis resolved or improved in 21 patients (61.8%) but did not change or worsen in 13 patients (38.2%). We found that complete resection of necrotic bone with intraoperative irrigation of the maxillary sinus may provide good treatment outcomes for maxillary sinusitis associated with MRONJ, although our findings were not statistically significant owing to the small number of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%