Treatment-emergent hypomania possibly associated with over-the-counter supplements

Olsufka, William; Abraham, Mary-Ann A.

doi:10.9740/mhc.2017.07.160

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…reported that G. simplicifolia and 5‐HTP were sold online as ingredients of ‘designer drugs’ or ‘party pills’ as an alternative to the synthetic psychoactive substance ecstasy [104] . A previous study demonstrated the occurrence of hypomania in a man using 5‐HTP and adenosylmethionine [105] . Another study reported a case of hospitalization due to serotonin syndrome associated with G. simplicifolia /5‐HTP supplementation [106]…”

Section: Ingredients Permitted (Or Not Specified) By Wadamentioning

confidence: 99%

Risk Associated with the Use of Selected Ingredients in Food Supplements

Jędrejko

Lazur

Muszyńska

2021

Chemistry & Biodiversity

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This review focuses on four new product categories of food supplements: pre‐workout, fat burner/thermogenic, brain/cognitive booster, and hormone/testosterone booster. Many food supplements have been shown to be contaminated with unauthorized substances. In some cases, the ingredients in the new categories of dietary supplements were medicinal products or new synthetic compounds added without performing clinical trials. Some of the new ingredients in dietary supplements are plant materials that are registered in the pharmacopoeia as herbal medicines. In other cases, dietary supplements may contain plant materials that have no history of human use and are often used as materials to ‘camouflage’ stimulants. In the European Union, new ingredients of dietary supplements, according to European Food Safety Authority or unauthorized novel food. Furthermore, selected ingredients in dietary supplements may be prohibited in sports and are recognized as doping agents by World Anti‐Doping Agency.

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Section: Ingredients Permitted (Or Not Specified) By Wadamentioning

confidence: 99%

Risk Associated with the Use of Selected Ingredients in Food Supplements

Jędrejko

Lazur

Muszyńska

2021

Chemistry & Biodiversity

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Evidence to Support the Use of S-Adenosylmethionine for Treatment of Post-Concussive Sequelae in the Military

Schieffler

Matta²

2021

Military Medicine

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Introduction Since the year 2000, over 413,000 service members have sustained traumatic brain injury (TBI) and may present with post-concussive sequelae including headaches, fatigue, irritability, cognitive problems, depression, insomnia, and chronic pain. Although the focus of the article is on military TBI, the usefulness of S-adenosylmethionine (SAMe) would extend to both civilian and military populations. This narrative review examines the preclinical and clinical literature of SAMe’s metabolism and alterations seen in disease states such as depressive disorders, pain disorders, fatigue, cognition, dementia, use in pregnancy and peripartum, children, adolescents, and adults, to the elderly with and without dementia, stroke, and neurodegeneration, in order to highlight its potential benefit in post-concussive sequelae after TBI. Materials and Methods A MEDLINE/PubMed and Cochrane Database search was conducted between May 3, 2018 and July 30, 2019 by combining search terms for SAMe with terms for relevant disease states including depression, brain injury, dementia, Alzheimer’s disease, Parkinson’s disease, cognition, fatigue, and pain. This search retrieved a total of 676 references. 439 were excluded for being over a 10-year publication date, except where clinically relevant. After additional removal of repeated articles, the number of articles were totaled 197. An additional 59 articles were excluded: 10 not in English, 4 duplicates, 4 not original investigations, and 41 outside the scope of this article. The remaining 138 articles were used in this review and included 25 clinical studies, 46 preclinical studies, 63 reviews, and 4 case reports. Results This narrative review examined the preclinical and clinical literature of SAMe’s metabolism and alterations seen in MDD, pain disorders, fatigue, cognition and memory, dementia, and other disorders to highlight the potential benefit of SAMe in post-concussive sequelae in mTBI. The literature showed potential for improvement, safety, and tolerability in these symptom clusters commonly seen in military mild TBI (mTBI). Conclusion There is evidence of a potential benefit of SAMe as an intervention to help with symptoms across the range of post-concussive sequelae and syndromes commonly seen in military mTBI. Since the discovery of SAMe in 1952, this pleiotropic molecule has shown the significance of its involvement in several metabolic cascades in such disparate systems as epigenetics, bioenergetics, DNA methylation, neurotransmitter systems, and potential usefulness in military TBI. Significant limitations include disparate presentations seen in patients with mild TBI, those with post-concussive syndrome, as well as those with comorbid depression and posttraumatic stress disorder. Also, over-the-counter medications are not regulated and SAMe products may vary widely in price and quality. Given the potential for mania in patients with bipolar disorder, evaluation and recommendations should be made by a physician able to evaluate the underlying bipolar diathesis. Furthermore, this narrative review serves as the rationale for future open-label and double-blind placebo-controlled trials in military mTBI and SAMe.

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The different roles of Griffonia simplicifolia in the treatment of depression: a narrative review

Ribas¹,

Oliveira²,

Silva³

et al. 2021

IJCAM

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The oldest recorded entry on the use of medicinal plants for the purpose of making a pharmacological compound for the treatment of diseases was found on a chalkstone, from approximately 3000 BC, from the ancient Sumerian civilization in Nagpur, a city in India, in the state of Maharashtra. 1,2 In this registry, 12 formulations were found for the organization and preparation of drugs consisting of more than 250 different herbs.There are reports in the literature that put the Egyptian civilization in this dispute for the pioneering of the discoveries of medicinal plants, dating from 6000years ago, approximately 4,000 BC, however, it includes, in addition to plants, products of animal origin. 3 Then, this dispute approaches, the Chinese book on roots and grasses, written by Emperor Shen Nung around 2500 BC, which discusses about 365 medicinal substances, derived from the dry parts of different plants and, at the same time, the encyclopaedia of the days Chinese medical material published in 1977 registered almost 6000 medicinal substances, of which 4800 are of plant origin. 1 The use of medicinal plants was also widespread among the peoples of India, around 2000years ago. 4 The Indian sacred books, Vedas, composed in a language called Vedic Sanskrit, mention the treatment with plants, which are abundant in that country. Many spice plants used today are from India, such as: nutmeg, pepper, cloves, among others. 1 The peoples of Mexico and Central America, the Aztecs, have been exploring the effectiveness of medicinal herbs for at least 1000years, even referring to treatments for simple diseases, such as acne, even the most complex, such as epilepsy. 3 In ancient history, the most relevant record on plant drugs was prepared by the Greco-Roman author, Pedânio Dioscórides, considered the founder of pharmacognosy, who, as a military doctor and responsible for pharmacology in Nero's army, studied medicinal plants. Around 77 AD, he wrote a work, 5 divided into 5 books, where, of the total of 944 drugs described, 35 drugs were of animal origin, 90 of mineral origin, of which only about 130 already appeared in the Corpus hippocraticum and 657 were of vegetable origin. 1 The great strength and the first leap, which made it possible to study the effects of medicinal plants, was given by a Swedish botanist, zoologist and physician, Carolus Linnaeus, creator of binomial nomenclature and scientific classification, considered the founder of modern taxonomy, who documented and classified in a standardized manner thousands of botanical species about medicinal plants in the 18th century. Species Plantarum was first published in 1753 in two volumes. 6 Anyway, there are several studies that address the effects of medicinal plants on diseases that affect the liver, kidneys, stomach,

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Treatment-emergent hypomania possibly associated with over-the-counter supplements

Cited by 5 publications

References 16 publications

Risk Associated with the Use of Selected Ingredients in Food Supplements

Risk Associated with the Use of Selected Ingredients in Food Supplements

Evidence to Support the Use of S-Adenosylmethionine for Treatment of Post-Concussive Sequelae in the Military

The different roles of Griffonia simplicifolia in the treatment of depression: a narrative review

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