Treatment for Malignant Struma Ovarii in the Eyes of Thyroid Surgeons

Abstract

Malignant struma ovarii (MSO) is a rare malignant ovarian germ cell tumor that has been scarcely reported by thyroid surgeons focusing on treatment. There are no golden standards for its treatment. There has not been any Chinese case included in the English language literatures. This is the first study by collecting all Chinese cases with clinical information. We emphasize on using I131 therapy after operation.Presented is a case of struma ovarii with malignant histologic features who underwent definitive initial surgery of reproductive system tumors and a total thyroidectomy combined with thyroid-stimulating hormone (TSH)-suppressive therapy following treatment with I131. Furthermore, a Chinese full-text database literature search for cases of MSO was performed, and advisable clinical data were collected following our treatment advice.Clinical data from 34 additional cases were compiled. As Chinese genetic background and environment are different from those of Western countries, our clinical data closely mirror theirs in some aspects. In addition, we provide a rare gene mutation type of MSO by the case from our department.Integrating literatures with the experience of thyroid surgeons, we recommend “multidisciplinary joint treatment” for MSO, namely traditional radical initial surgery of ovarian cancer and a total thyroidectomy combined with TSH-suppressive therapy following treatment with I131 for those who do not desire preservation of fertility.

Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report

“… [13] . The management of thyroid nodules in these patients varies as well, including regular checkups with ultrasound and thyroglobulin levels or a total thyroidectomy with or without 131 I radioablation therapy postoperatively [14] , [15] .…”

Struma Ovarii. Can we face this Challenge? A Case Report

“…Due to its rarity, there is no consensus on stratifying risk or establishing optimal treatment for malignant SO. After the second surgery we were facing a metastatic scenario of malignant SO, in which many authors suggest the same management as differentiated thyroid cancer [6]. According to this, we performed surgical removal of the tumor as the initial step, followed by prophylactic total thyroidectomy (eliminating all possibilities of hidden thyroid primary malignancy).…”