Treatment of acne vulgaris

Nguyen, Rebecca; Su, John

doi:10.1016/j.paed.2010.09.012

Cited by 20 publications

(20 citation statements)

References 12 publications

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“…The prevalence tended to lower with age. It was around 10% after 25 years and 6% after 40 years of age (1). Acne vulgaris is not a life-threatening disease but it can lead to physical problems such as inflammatory lesions, permanent scars, and keloids.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

et al. 2013

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The objective of this study was to study the effect of formulation compositions on physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract (AM). Film-forming solution bases and film-forming solutions containing AM were prepared by using Eudragit RL PO or Klucel LF or combinations of them as film-forming polymers. Rheological properties, pH values of the solutions, and mechanical properties of the dry films were investigated. An optimized formulation was selected and evaluated for the film surface, in vitro AM release, an anti-P. acnes activity, and potential for being a skin irritant. It was found that mechanical properties of the dry films were affected by total polymer contents, ratios of Klucel LF/Eudragit RL PO, AM, and contents of triethyl citrate. The film-forming solutions containing AM had pH values around 7.0. Their flow curves exhibited Newtonian flow behaviors. The optimized formulation provided films possessing smooth and nonporous surfaces. These films showed greater anti-P. acnes activity than their base films without toxicity to skin fibroblasts. Furthermore, AM released from the film matrix obeyed Higuchi's equation. In conclusion, the film-forming solutions containing AM had potential for treatment of acne vulgaris caused by P. acnes. However, further in vivo study is necessary to determine their efficacy and safety for using in patients suffering from acne vulgaris.

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Section: Introductionmentioning

confidence: 99%

Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

et al. 2013

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“…Treatment options include suitable skin care, topical and oral antimicrobial agents, retinoid, benzoyl peroxide, and oral contraceptive. These are frequently combined and can be readjusted as needed …”

Section: Resultsmentioning

confidence: 99%

“…These are frequently combined and can be readjusted as needed. 13,14 P. acnes are anaerobic gram-positive bacteria that colonize and live in the human skin, especially in pilosebaceous follicles.…”

Section: Acnementioning

confidence: 99%

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

Mottin

Suyenaga

2018

Int J Dermatology

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Acne and Atopic Dermatitis (AD) are chronic inflammatory skin conditions with severe impact on a patient's life. Current treatments are related to adverse effects and do not represent a definitive cure. The present paper reviews the alterations in skin microbiome, specifically in acne and AD, and aims in searching for potential treatments based on benefic microorganisms, called probiotics. The review was made through bibliographic search of the main databases (Science Direct, PubMed, Scielo, Medline) between September 2015 and June 2016. Acne lesions create an environment that facilitates the excess growth of Propionibacterium acnes (P. acnes). AD is related to an increase in the proportion of Staphylococcus aureus (S. aureus) during flare-ups. Some microorganisms have been shown to act not only in the prevention but also in the competition for pathogenic microorganisms and beneficially affect the inflammatory process present in these conditions. Despite the high variety of tested bacteria, Staphylococcus, Streptococcus, Lactococcus, Lactobacillus, and Enterococcus are the ones which showed the highest potential to control acne, and Vitreoscilla filiformis (V. filiformis), Staphylococcus epidermidis (S. epidermidis), and species of Lactobacillus and Bifidobacterium in the treatment of AD. Many of these studies were in vitro, and more detailed research should be performed in order to prove the real efficacy and safety of probiotics in these situations. An interesting alternative seems to be the use of Bacteriocin-like inhibitory substances produced by probiotics, responsible for their antimicrobial activity.

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“…, Pseudomonas or Klebsiella spp. (24,25). As noted above, in terms of the photodynamic eradication of such pathogens, these cationic photosensitizers are highly effective against Gram‐negative bacteria, whereas their anionic counterparts, such as the hematoporphyrin derivatives are very weak (26), although protoporphyrin IX, if produced in situ ( i.e.…”

Section: Discussionmentioning

confidence: 99%

Comparative Photodynamic Evaluation of New Phenothiazinium Derivatives against Propionibacterium acnes^†

Wainwright

Smalley

Scully

et al. 2011

Photochem & Photobiology

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The screening of recently patented derivatives of the standard phenothiazinium agents methylene blue and toluidine blue was carried out against Propionibacterium acnes, the main bacterium associated with acne vulgaris. Comparative tests were made using the topical agent benzoyl peroxide (BPO) and standard tetracyclines. Each of the photosensitizers employed, including the lead compounds, was photobactericidal at lower concentrations than BPO, and produced a much more rapid kill than the tetracyclines. In addition, the tetracyclic and pentacyclic phenothiazinium derivatives exhibited high light:dark kill ratios, suggesting that these examples might be particularly useful in practice.

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Treatment of acne vulgaris

Cited by 20 publications

References 12 publications

Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

Comparative Photodynamic Evaluation of New Phenothiazinium Derivatives against Propionibacterium acnes^†

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Treatment of acne vulgaris

Cited by 20 publications

References 12 publications

Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

Comparative Photodynamic Evaluation of New Phenothiazinium Derivatives against Propionibacterium acnes†

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Comparative Photodynamic Evaluation of New Phenothiazinium Derivatives against Propionibacterium acnes^†