Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs

Abstract

Asthmatic inflammation is mediated by a type 2 helper T cell (Th2) cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein (GFP) reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.

Structural elucidation ofin vitrometabolites of bavachinin in rat liver microsomes by LC-ESI-MSnand chemical synthesis

“…Bavachinin (Figure 1), isolated from P. corylifolia (Chen et al, 2012), is a prenylated flavonoid. Bavachinin exhibits antiallergic, anti-inflammatory (Chen et al, 2013(Chen et al, , 2014, antiangiogenic, antitumor (Nepal et al, 2012) and antioxidant activities (Xiao et al, 2010), and inhibits severe acute respiratory syndrome coronavirus papain-like protease (Kim et al, 2014). In our study (WO2014/169800), natural bavachinin exhibited peroxisome proliferator-activated receptor g (PPAR-g) agonist activity.…”

Enhancing the Therapeutic Efficacy of Daunorubicin and Mitoxantrone with Bavachinin, Candidone, and Tephrosin

“…Lately, three flavonoids, namely, bavachinin [12], candidone [13], and tephrosin [14], have been introduced to cancer treatment research. Bavachinin is a flavonoid obtained from the seeds of Psoralea corylifolia Linn that displays various activities, including antiangiogenic, antitumor [15], antibacterial [16], antiallergic, and anti-inflammatory activities [17, 18]. Moreover, candidone, which is obtained from the stems and leaves of Tephrosia candida [19], exhibits antitumor [13] and antibacterial activities [20].…”

Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways

“…It has been reported as a natural pan-PPAR agonist to lower glucose and triacylglycerol levels in db/db mice [ 14 , 15 ]. Bavachinin, as a potent anti-asthma drug, significantly inhibits Th2 cytokine production, including IL-4, IL-5 and IL-13 [ 16 , 17 ]. Bavachinin has potent anti-angiogenic and anti-tumor activity in vitro and in vivo by targeting hypoxia-inducible factor-1α [ 18 ].…”