Treatment of antigen‐induced arthritis in rabbits with dysprosium‐165–ferric hydroxide macroaggregates

Zuckerman, Joseph D.; Sledge, Clement B.; Shortkroff, Sonya; Venkatesan, Prasanna

doi:10.1002/jor.1100070108

Cited by 16 publications

(5 citation statements)

References 13 publications

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“…Arthritis was induced according to the methodology described by Zuckerman et al [12]. NZW rabbits were primed with ovalbumin, with booster injections of ovalbumin given 2 and 5 weeks later.…”

Section: Induction Of Arthritis In Rabbitsmentioning

confidence: 99%

Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration

Chowdhary¹,

Ratkay²,

Canaan³

et al. 1998

Biopharm. Drug Dispos.

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Section: Induction Of Arthritis In Rabbitsmentioning

confidence: 99%

Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration

Chowdhary¹,

Ratkay²,

Canaan³

et al. 1998

Biopharm. Drug Dispos.

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“…Attempts to destroy proliferative synovium with chemical compounds have been too destructive of other normal articular tissues to merit clinical use ( 1 4 ) . Radiation synovectomies have had limited success (5)(6)(7)(8)(9)(10). In this study we investigate the feasibility of using photodynamic therapy to destroy diseased synovium in an effort to develop a less invasive and less morbid synovectomy technique.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Synovectomy Using Benzoporphyrin Derivative in an Antigen‐induced Arthritis Model for Rheumatoid Arthritis

Trauner

Gandour‐Edwards

Bamberg

et al. 1998

Photochem & Photobiology

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Experimental photodynamic therapy (PDT) has recently been adapted for the treatment of inflammatory and rheumatoid arthritis. The biodistribution of benzoporphyrin derivative monoacid ring A (BPD-MA) and the effect of percutaneous light activation via intra-articular bare cleaved optical fibers was investigated using a rabbit-antigen-induced arthritis model. Qualitative evaluation of intra-articular photosensitizer clearance was performed with laser-induced fluorescence from 0 to 6 h following intravenous injection. The compound was rapidly taken up within the joint and then cleared steadily over the 6 h interval. Biodistribution was determined by fluorescence microscopy and spectrofluoroscopic extraction techniques 3 h following intravenous injection of 2 mg/kg BPD-MA. The biodistribution study demonstrated elevated levels of BPD-MA in synovium (0.35 microgram/g) and muscle (0.35 microgram/g). Fluorescence microscopy demonstrated presence of the compound within pathologic synovium but absence of the photosensitizer within meniscus, ligament, bone and articular cartilage. Tissue effects were evaluated histologically at 2 and 4 weeks posttreatment. BPD-MA-mediated PDT caused synovial necrosis in the region of light activation in 50% of treatment knees at 2 weeks and 43% at 4 weeks. No damage to nonpathologic tissues was observed. These studies indicate that selective destruction of synovium can be achieved by the light-activated photosensitizing agent BPD-MA without damage to articular cartilage or periarticular soft tissues. PDT needs to be further evaluated to optimize treatment parameters to provide for a new minimally invasive synovectomy technique.

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“…Articular cartilage appears to be highly resistant to radiation , although animal data are limited and contradictory. Atrophy of the articular cartilage and severe disorganization of the growth plates were reported in a controlled study of 300 g rats given intra‐articular injections of 0.25 mCi P‐32.…”

Section: Radiosynovectomy Safety Concernsmentioning

confidence: 99%

Opinions on radiosynovectomy for chronic haemophilic synovitis: point/counterpoint

2012

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Joint bleeding is the hallmark of severe haemophilia and the major cause of disability in patients with this coagulopathy. Repeated bleeding into the same joint can lead to chronic synovitis and progressive arthropathy. Radiosynovectomy is one option for the treatment of chronic haemophilic synovitis, but concerns about the risks of exposure to ionizing radiation have divided clinicians as to the safety and appropriate use of the procedure. This article presents two differing viewpoints, one from a pair of orthopaedic surgeons who collectively have performed more than 300 radiosynovectomies in patients with haemophilia. They maintain that radiosynovectomy is a simple, effective, safe and low-cost technique children and adults with chronic haemophilic synovitis. The other perspective is from an experienced haemophilia treater who directs a major US haemophilia treatment centre. She believes that unresolved questions about the safety of radiation exposure in children argue against the use of radiosynovectomy in paediatric patients with haemophilia.

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Treatment of antigen‐induced arthritis in rabbits with dysprosium‐165–ferric hydroxide macroaggregates

Cited by 16 publications

References 13 publications

Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration

Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration

Photodynamic Synovectomy Using Benzoporphyrin Derivative in an Antigen‐induced Arthritis Model for Rheumatoid Arthritis

Opinions on radiosynovectomy for chronic haemophilic synovitis: point/counterpoint

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