Treatment of Anxiety and Depression in Adolescents and Young Adults With Cancer

Lauer, Amy

doi:10.1177/1043454214563406

Cited by 38 publications

(32 citation statements)

References 23 publications

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“…Medical teams often first become aware of significant emotional distress once it becomes acute, such as when a child is not adherent to medications, severely depressed or even suicidal . This reactive approach can result in additional trauma to the child and family, jeopardizing their rapport with the team as well as effective participation in their treatment .…”

Section: Discussionmentioning

confidence: 99%

Validity, specificity, feasibility and acceptability of a brief pediatric distress thermometer in outpatient clinics

et al. 2015

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Objective Psychosocial distress is under‐recognized in children with cancer and other serious medical illnesses because of a focus on pressing medical concerns. Aims This study assessed the validity, inter‐rater reliability, sensitivity/specificity, acceptability, and feasibility of administration of a pediatric distress thermometer (DT) designed to screen for the presence of psychosocial distress in youth with serious medical illnesses. Materials & Methods Two hundred eighty‐one patient–caregiver–provider triads were enrolled from two hospital outpatient clinics. Patients diagnosed with cancer and other life‐threatening diseases, caregivers, and providers completed the DT and a DT acceptability rating. Patients and caregivers completed standardized measures of anxiety, depression, pain, and fatigue. Providers completed a measure of disease severity. Data collectors completed a feasibility rating. Results The DT was significantly correlated with both caregiver and patient reports of depression, anxiety, pain, and fatigue, exhibiting concurrent validity. Parent, child, and caregiver report demonstrated significant, moderate inter‐rater reliability, with lower concordance between raters in the youngest age group. The DT is a sensitive instrument for screening of psychosocial distress when compared with the selected gold standard (Brief Symptom Inventory 18 depression subscale and the Children's Depression Inventory). The DT is not highly specific but quickly identifies those in need of further psychosocial assessment. Discussion Screening, using an adapted pediatric DT, is valid, feasible, and acceptable to patients, caregivers, and medical providers across chronic medical illnesses. Conclusion As patient and caregiver reports are not always concordant, both patient and caregiver report of distress are important for the provider to obtain clinically meaningful information to guide interventions. Published 2015. This article is a U.S. Government work and is in the public domain in the USA

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Section: Discussionmentioning

confidence: 99%

Validity, specificity, feasibility and acceptability of a brief pediatric distress thermometer in outpatient clinics

et al. 2015

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“…Although estimated prevalence rates for depression in the AYA population are conflicting due to inconsistencies in how AYAs are screened and treated for anxiety and depression, 47 it is the symptoms of depression, including disturbed sleep, fatigue, and poor appetite, that are most salient and bothersome, and these symptoms can bring delays or alterations in treatment. 48 Importantly, many of the symptoms of depression are also side effects of treatment.…”

Section: Developmental Impact 14mentioning

confidence: 97%

The Adolescent and Young Adult with Cancer: A Developmental Life Course Perspective

Docherty

Kayle

Maslow

et al. 2015

Seminars in Oncology Nursing

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“…Improved cure rates for childhood cancer have allowed clinicians and researchers to expand focus beyond disease treatment to explore psychosocial outcomes. Stressors of a cancer diagnosis and treatment are substantial and may impact psychosocial well‐being in children with cancer . These stressors may include changes in daily activities, coping with adverse side effects, and disruption of developmental milestones .…”

Section: Introductionmentioning

confidence: 99%

“…Stressors of a cancer diagnosis and treatment are substantial and may impact psychosocial well‐being in children with cancer . These stressors may include changes in daily activities, coping with adverse side effects, and disruption of developmental milestones . Children who undergo hematopoietic stem cell transplantation (HSCT) face a symptom burden and stressors similar to that of children receiving chemotherapy .…”

Section: Introductionmentioning

confidence: 99%

Severity, change over time, and risk factors of anxiety in children with cancer depend on anxiety instrument used

et al. 2019

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Objective The primary objective was to describe severity of anxiety among children and adolescents receiving chemotherapy for cancer or undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives were to describe how anxiety changes over time and determine factors associated with anxiety. Methods Participants were aged 8 to 18 and either receiving chemotherapy for cancer or undergoing HSCT for any indication. Respondents self‐reported three anxiety measurement instruments at chemotherapy cycle or HSCT conditioning start and 3 weeks later. Results The proportion of participants with severe anxiety ranged from 10/77 (13.0%) to 22/77 (28.6%) depending on instrument used. Change over time also varied across instruments, with significant improvement observed with PedsQL (procedural) (P = 0.037) and PROMIS (P = 0.013). Factors associated with anxiety similarly varied by instrument. Older age was associated with more anxiety on the PedsQL (worry) (P = 0.036), and higher household income was associated with less anxiety on the MASC‐10 (P = 0.028). Conclusions While we found that a small proportion of patients met or exceeded thresholds for severe anxiety, we also noted that severity, change over time, and predictors of anxiety varied depending on instrument used. Future research should ensure that selected instruments measure the construct of interest and describe how anxiety is conceptualized in the study.

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Treatment of Anxiety and Depression in Adolescents and Young Adults With Cancer

Cited by 38 publications

References 23 publications

Validity, specificity, feasibility and acceptability of a brief pediatric distress thermometer in outpatient clinics

Validity, specificity, feasibility and acceptability of a brief pediatric distress thermometer in outpatient clinics

The Adolescent and Young Adult with Cancer: A Developmental Life Course Perspective

Severity, change over time, and risk factors of anxiety in children with cancer depend on anxiety instrument used

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