Treatment of Articular Cartilage Lesions of the Knee by Microfracture or Autologous Chondrocyte Implantation: A Systematic Review

Oussedik, Sam; Tsitskaris, Konstantinos; Parker, David

doi:10.1016/j.arthro.2014.11.023

Cited by 150 publications

(107 citation statements)

References 39 publications

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“…As published earlier, the 5-year results provided strong support for the benefit of MACI. 9 This fact is underlined by the score values at 15-year follow-up showing still a slightly increase in clinical 2 3.6 (range: 1.5-8.75) Outerbridge classificiation:…”

Section: Discussionmentioning

confidence: 84%

Matrix-Associated Autologous Chondrocyte Implantation

Gille¹,

Behrens²,

Schulz³

et al. 2016

CARTILAGE

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Section: Discussionmentioning

confidence: 84%

Matrix-Associated Autologous Chondrocyte Implantation

Gille¹,

Behrens²,

Schulz³

et al. 2016

CARTILAGE

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“…Although these treatments have their advantages, a more convenient treatment technique would (1) be less invasive; (2) be a one-time process; (3) create tissues very similar in composition to native tissue; and (4) has a shorter treatment course [307, 309]. The complexities of hyaline cartilage tissue has been a major obstacle to engineer cartilage.…”

Section: Cartilage Regenerationmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

391

240

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Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.

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“…Currently available surgical interventions include microfracture, autologous or allogeneic osteochondral grafts and autologous chondrocyte implantation [42, 43]. However, almost all interventions have more or less the same problem of fibro-like cartilage: excessive type I collagen production in regenerating cartilage [44-46]. Fibro-like cartilage cannot resist mechanical stress to the same extent as normal hyaline cartilage with type II collagen and is thus vulnerable to injury [45, 47].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis Reveals a New Benefit of Periodic Mechanical Stress on Chondrocytes

Zeng¹,

Wang²,

Xu³

et al. 2017

Cell Physiol Biochem

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Background/Aims: In recent years, a variety of studies have been performed to investigate the cellular responses of periodic mechanical stress. In our previous studies, we found that periodic mechanical stress can promote proliferation and matrix synthesis through the integrin beta 1-mediated ERK1/2 pathway, and we used proteomic analysis to detect quantitative changes in chondrocytes under periodic mechanical stress. Despite these results, the effects and mechanisms of periodic mechanical stress are still not fully understood, so in this study we extended our study using phosphoproteomic techniques. Methods: We used phosphoproteomic techniques to detect phosphorylation changes in chondrocytes under periodic mechanical stress and combined the results with the quantitative proteomic data to further explore the underlying mechanisms. Data were obtained by phosphorylation inhibition, quantitative real-time PCR (qPCR) analysis, western blot analysis and immunofluorescence assay. Results: From phosphoproteomic analysis, a total of 1073 phosphorylated proteins and 2054 phosphopeptides were identified. The number of significant differentially expressed proteins and phosphopeptides was 97 and 108, respectively (ratio >1.20 or <0.83 at p<0.05). Periodic mechanical stress increased glycogen synthase kinase 3-beta (GSK3-beta) phosphorylation at Y216, promoted the phosphorylation of beta-catenin, decreased beta-catenin levels and suppressed the expression of type I collagen. In contrast, inhibition of GSK3-beta by TWS119, which specifically inhibits the phosphorylation of Y216, suppressed the phosphorylation of beta-catenin, which resulted in the accumulation of beta-catenin and an increase in the expression of type I collagen. Conclusions: We successfully constructed differentially expressed phosphoproteomic profiles of rat chondrocytes under periodic mechanical stress, and discovered a potential new therapeutic benefit in which periodic mechanical stress suppressed the formation of type I collagen in the matrix of chondrocytes via phosphorylation of GSK3-beta and beta-catenin.

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Treatment of Articular Cartilage Lesions of the Knee by Microfracture or Autologous Chondrocyte Implantation: A Systematic Review

Cited by 150 publications

References 39 publications

Matrix-Associated Autologous Chondrocyte Implantation

Matrix-Associated Autologous Chondrocyte Implantation

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Proteomic Analysis Reveals a New Benefit of Periodic Mechanical Stress on Chondrocytes

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