Treatment of Aspergillus fumigatus Keratitis in Rabbits with Oral and Topical Ketoconazole

Komadina, Thomas G.; David, Thierry; Wilkes, I.; Shock, John P.; Ulmer, W. Clyde; Jackson, James H.; Bradsher, Robert W.

doi:10.1016/0002-9394(85)90017-0

Cited by 31 publications

(10 citation statements)

References 9 publications

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“…In group 2, two of 14 samples showed candida growth. These 14 3 0 Group 2 (fluconazole without debridement) 14 6 1 Group 3a (0 9% NaCl+debridement) 6 6 5…”

Section: Resultsmentioning

confidence: 99%

“…2 Apart from polyenes such as amphotericin-B, nystatin, and pimaricin (natamycin), azoles such as the imidazoles and ketoconazole have been applied to fungal keratitis. The azoles proved effective and were non-toxic to the eye.34 However, the treatment of clinical keratomycoses is still inefficient.5 6 Fluconazole (2-(2,4,-difluorophenyl)-1,3-bis (1 H-1,2,4-triazol-1-yl) propan-2-ol; UK 49*858) is a new triazole compound (molecular weight 306&3) which has certain properties suggesting its use for the treatment of fungal keratitis. It has been reported to be more efficient than ketoconazole in systemic candidosis of immunosuppressed as well as normal mice.78 Moreover, fluconazole is the only antifungal azole derivative which penetrates into the cerebrospinal fluid.9'0 Parenterally administered fluconazole under experimental conditions was shown to penetrate freely into ocular tissues.…”

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confidence: 99%

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Topical fluconazole for experimental candida keratitis in rabbits.

Behrens–Baumann

Klinge

Rüchel

1990

British Journal of Ophthalmology

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Using a reproducible model of Candida albicans keratitis in rabbits we studied the effect of topical fluconazole, a new triazole. Candida albicans DSM 70010 (2.5X10 cells) was injected into the corneal stroma of both eyes of21 rabbits. AU eyes developed a corneal ulcer. Forty-eight hours after inoculation the animals were divided into three groups: (1) 14 eyes, received fluconazole (2 mg/ml) and the epithelium subsequently removed; (2) 14 eyes, received only fluconazole drops; (3) 14 eyes, received 0/9% NaCI: half ofthis group was also debrided. We applied one drop of either substance 10 times a day for 24 days. A further six rabbits were used to judge if the drug penetrated into the cornea and aqueous humour. There was a highly significant difference between the fluconazole groups (1, 2) and the control group (3) as to hypopyon and complications (descemetocele, corneal perforation) as well as recultivation of C. albicans from corneal tissue. The difference between the fluconazole groups with and without debridement was not significant. The drug penetrated into the cornea and aqueous humour of both uninflamed and inflamed eyes.

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“…In group 2, two of 14 samples showed candida growth. These 14 3 0 Group 2 (fluconazole without debridement) 14 6 1 Group 3a (0 9% NaCl+debridement) 6 6 5…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Topical fluconazole for experimental candida keratitis in rabbits.

Behrens–Baumann

Klinge

Rüchel

1990

British Journal of Ophthalmology

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“…Komadina et al and Singh et al, comparing topical and oral KCZ with NTM, showed that the latter is superior. A partial response was also achieved with isolated oral administration, with increased effect when combined with topical NTM (75,76) . In vitro studies with strains of Aspergillus spp.…”

Section: -Econazolementioning

confidence: 91%

Antifúngicos em infecções oculares: drogas e vias de administração

Müller¹,

Kara‐José²,

Castro³

2013

Rev. bras.oftalmol.

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RESUMOO tratamento das infecções oculares por fungos representa um desafio à prática oftalmológica. Para obtermos resposta terapêutica adequada, além do uso da droga correta, é necessária a administração desta de forma eficaz. Este manuscrito reúne informações a respeito das principais drogas antifúngicas utilizadas em infecções oculares, suas concentrações e principais vias de administração.

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“…However, when kétoconazole (either oral or top ical administration) was used in conjunction with natamycin, it appeared to augment the sterilization of the fungus in this model of experimental keratitis [28], O'Day et al [29] described a case of deep corneal abscess caused by ,4s-pergillus sp. which was successfully controlled by a com bined corticosteroid-antifungal (amph B. nystatin) medi cation, followed by penetrating keratoplasty.…”

Section: Kétoconazolementioning

confidence: 99%

“…In a rabbit model [28], neither oral nor topical kéto conazole alone was effective against A. fumigatus-induced keratitis. However, when kétoconazole (either oral or top ical administration) was used in conjunction with natamycin, it appeared to augment the sterilization of the fungus in this model of experimental keratitis [28], O'Day et al [29] described a case of deep corneal abscess caused by ,4s-pergillus sp.…”

Section: Kétoconazolementioning

confidence: 99%