Treatment of Atrophies Secondary to Trilinear Scleroderma En Coup de Sabre by Autologous Tissue Cocktail Injection

Oh, Chang‐Keun; Liu, Jin; Jang, Bong-Seok; Kang, Young-Seok; Bae, Yong-Chan; Kwon, Kyung‐Sool; Jang, Ho‐Sun

doi:10.1046/j.1524-4725.2003.29307.x

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…We evidenced histologically that the MF injection was more efficient than fat injection in reducing bleomycin (BLM)-induced injury, as shown by reduction of dermis thickness ( P <0.05 with Coleman’s technique and P <0.01 with the technique of microinjection) and improved vascularization of the deep dermis and subcutis ( P <0.01). Otherwise, these results are consistent with previously reported clinical data for localized scleroderma [ 28 , 29 ] as well as other skin lesions [ 30 ]. Hence, fat microinjection appeared more suitable for injection or subdermal fibrotic tissue.…”

Section: Introductionsupporting

confidence: 93%

New fat-derived products for treating skin-induced lesions of scleroderma in nude mice

et al. 2014

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IntroductionScleroderma is characterized by cutaneous manifestations that mainly affect the hands, arms and face. As of today, there is no treatment for fibrotic skin lesions of scleroderma. Previously we generated and validated a model of scleroderma-like skin sclerosis in nude mice, appropriate to inject human derived products. We showed that the subcutaneous injection of micro-fat (MF), purified and injected using small caliber cannulas, have anti-fibrotic and pro-angiogenic effects and appears more suitable for the treatment of skin lesions of scleroderma compared to the gold standard (Coleman’s technique or macro-fat). Here we compared the long-term efficacy of micro-fat “enriched” with other therapeutic products including the stromal vascular fraction (SVF) of fat and platelet-rich plasma (PRP) from blood in our murine model of scleroderma.MethodsWe used 72 nude mice in this study. We formed six experimental groups: Macro-fat, MF, SVF, PRP, MF + SVF, MF + PRP. This project has three phases: i) Induction of skin sclerosis by daily subcutaneous injections of bleomycin (BLM) for 4 weeks in nude mice; ii) Purification and injection of the different cell therapy products; iii) Histological analyses done 8 weeks post-injections.ResultsMF + SVF and MF + PRP significantly reversed dermal and epidermal sclerosis (P <0.01). Macro-fat, SVF, PRP only corrected the dermal sclerosis (P <0.05). Epidermal sclerosis was reduced in treatments containing MF (P <0.01). MF was more stable. Products containing the SVF were associated with a significant increase of the local vascularization (P <0.01).ConclusionsAll tested substances were effective in treating skin-induced lesions of scleroderma with different levels of fibrosis and vascular improvement; MF derived products are more stable and SVF demonstrated better pro-angiogenic effects. The observed efficacy of this combination of products in the animal model provides a rationale for potential clinical applications to treat human disease.

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Section: Introductionsupporting

confidence: 93%

New fat-derived products for treating skin-induced lesions of scleroderma in nude mice

et al. 2014

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“…Other treatment modalities include physical therapy techniques both for improving range of motion of affected limbs as well as stretching exercises for contractures. Finally, for skin lesions that have not demonstrated evidence of disease activity in more than 2 years, plastic surgery reconstructive techniques [83] can be employed to improve the appearance of the ''burned out'' skin lesions.…”

Section: Juvenile Localized Sclerodermamentioning

confidence: 99%

Skin Signs of Systemic Disease in Childhood

Gilliam

2006

Advances in Dermatology

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Several systemic disorders of childhood are characterized by cutaneous stigmata, and these skin signs can serve as important diagnostic clues. Many of the systemic illnesses that are seen in both the pediatric and adult populations often manifest in different ways with respect to their cutaneous features. Also, there are conditions that uniquely present in childhood, such as KD, HSP, acute hemmorhagic edema of infancy, and NOMID. Early recognition of these disorders is important for initiation of appropriate therapy and prevention of adverse outcomes.

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“…Although cosmetic improvements have been noted with such procedures, many of these treatment methods carry significant risks, require a substantial recovery period, or both. Other less‐invasive treatment modalities have been also documented, with autologous fat grafting, tissue cocktail injections, and poly‐ l ‐lactic acid injections having been described in the literature 9–12 . Autologous fat transfer requires harvesting of fat from a distant site and therefore necessitates an additional procedure, whereas the use of poly‐ l ‐lactic acid injections often requires several treatment sessions for optimal results and involves delayed cosmetic benefits.…”

Section: Discussionmentioning

confidence: 99%

Linear Morphea-Induced Atrophy Treated with Hyaluronic Acid Filler Injections

Choksi

Orringer

2011

Dermatologic Surgery

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Treatment of Atrophies Secondary to Trilinear Scleroderma En Coup de Sabre by Autologous Tissue Cocktail Injection

Abstract: Autologous tissue cocktail injection appears to be a useful method for the correction of depressed atrophy of linear scleroderma en coup de sabre.

Cited by 16 publications

References 9 publications

New fat-derived products for treating skin-induced lesions of scleroderma in nude mice

New fat-derived products for treating skin-induced lesions of scleroderma in nude mice

Skin Signs of Systemic Disease in Childhood

Linear Morphea-Induced Atrophy Treated with Hyaluronic Acid Filler Injections

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