Treatment of Basal Cell Cancer With a Pulsed Copper Vapor Laser: A Case Series

Abstract

Introduction: Basal cell carcinoma (BCC) is the most prevalent form of non-melanoma skin cancer commonly arising in elderly patients. Currently, many laser systems are applied for the treatment of BCC. However, up to the present, there have been several reports concerning ocular side effects due to the laser procedure in the borders of the periorbital area. This determines the feasibility of testing new laser surgical modes for the management of periorbital BCC. This stuay aimed to estimate both the efficacy, the early post-radiated side effects and long-term outcomes of the CVL treatment of periorbital BCC. Patients and Methods: Two men and 6 women aged 50 to 77 years were diagnosed with periorbital BCC according to the data of both the clinical evaluation and histological examination of the tissue samples taken from the involved area. Six months after the laser treatment, the histological examination of skin samples from the borderline of the irradiated area was made again. All patients were followed for 24 months after the laser treatment of BCC. The laser treatment was administered during one session of copper vapor laser (CVL) (Yakhroma-Med model). The treatment included CVL radiation with a wavelength of 511 nm and 578 nm, in the ratio of 3:2. The power level was set up to 3 W, and the exposure time was equal from 200 to 600 ms. The pulse duration accounted for 15 ns. The diameter of the light spot on the skin surface amounted to 1 mm. Results: Dual-wavelengths CVL treatment of periorbital BCC provided a complete elimination of malignant cells and dysplastic vessels during one procedure. The duration of skin healing amounted to 2-4 weeks. There were neither ocular injuries or pronounced skin side effects nor relapses within 24 months after the laser procedure. Conclusion: CVL treatment of periorbital BCC provides relevant cosmetic results without ocular injuries and relapses.

Semiclassical Approach to the Nonlocal Kinetic Model of Metal Vapor Active Media

“…Studies of kinetics of metal vapor active media (MVAM) are motivated by their wide application in the development of laser systems. MVAM are used in technics due to their high optical gain in a narrow spectral range [1][2][3]. Nowadays, the most promising application of MVAM are the active optical systems (the so-called laser monitors) that allow one to visualize the processes blocked by the intense strong background light [4,5].…”

The Successful Treatment of Eyelid Intradermal Melanocytic Nevi (Nevus of Miescher)With the Dual-Wavelengths Copper Vapor Laser

“…The effective penetration Successful Treatment of Miescher Nevus With the Dual-Wavelengths CVL CVL depth does not exceed the thickness of the eyelid dermis. 4,11 Nevomelanocytes induce hypoxic endothelial dysfunction in the microvessel NM-involved area. The prevention of the recurrence of nevomelanocytosis of the dermis requires the remodeling of the microvascular bed near the NM-involved area.…”

“…10 CVL radiation can be applied safely in the eyelid area due to high absorption by melanin, oxyhemoglobin, and hemoglobin. 11 This case series presents the experience of removing medium-and large-sized eyelid NM using dualwavelengths CVL radiation.…”

Epidermal nevus in blaschkoid distribution treated with dual-wavelength copper vapor laser

“…6 The high simultaneous absorption of dual-wavelength copper vapor laser radiation at 511 nm and 578 nm by all the target nevus sebaceous chromophores provided the sound removal of nevus sebaceous due to the appropriate heating of melanin in acanthotic cells, sufficient sebum discharge and photodestruction of the involved dilated microvascular bed. 7 Copper vapor laser at 578 nm, mostly absorbed by oxyhemoglobin and deoxyhemoglobin, provides appropriate photocoagulation followed by the remodeling of the vascular bed, likely preventing both relapses and malignant change in facial blaschkoid nevus. 7 The limited penetration depth of copper vapor laser in the dermis due to the high absorption of radiation by melanin, sebum lipids, oxyhemoglobin and hemoglobin determines the main advantage of copper vapor laser in comparison with other laser systems.…”

“…7 Copper vapor laser at 578 nm, mostly absorbed by oxyhemoglobin and deoxyhemoglobin, provides appropriate photocoagulation followed by the remodeling of the vascular bed, likely preventing both relapses and malignant change in facial blaschkoid nevus. 7 The limited penetration depth of copper vapor laser in the dermis due to the high absorption of radiation by melanin, sebum lipids, oxyhemoglobin and hemoglobin determines the main advantage of copper vapor laser in comparison with other laser systems. Copper vapor laser neither passes into the deep dermis nor overheats dermal stem cells, essential for the appropriate skin healing after the laser exposure.…”