Treatment of Benign Prostatic Hyperplasia by Phenol Injection1

Abstract

SUMMARY Eighty‐five patients with benign prostatic hyperplasia, who were bad risks for prostatectomy, were treated by injection of phenol into the adenoma. Two out of three with retention were relieved. The technique proved less successful for those without retention: this is attributed to bad selection of cases and to the incidence of retention and exacerbation of symptoms as complications.

Tissue Chemoablation

“…56 This procedure was later abandoned because of the high rate of local complications and the inconsistent results. However, the efficacy of phenol in causing prostatic necrosis was confirmed in work by Angell,57 as well as in studies by Choudhury and Maulik. 58 These authors reported focal necrosis within enucleated adenomas.…”

Intraprostatic ethanol diffusion: comparison of two injection methods using ex vivo human prostates

“…Significant adverse events were noted as the caustic substance leaked out of the prostate. 19,20 A recent study, which used TRUS-guided intraprostatic ethanol injection, also reported procedure-related complications, although only when higher ethanol volumes were injected. 21 These complications highlight the need for an injection technique with a suitable safety profile.…”

Transurethral ethanol injection therapy of benign prostatic hyperplasia: Four‐year follow‐up

“…The first and most commonly used substance was phenol 13 . Its use showed that intraprostatic injection for the treatment of BPH is a simple, effective and safe technique that can be used for high‐risk patients.…”

“…The injection was carried out through a percutaneous, transperineal route. The main drawback of this technique was that sometimes several injections were needed to obtain an adequate response, 13 and the associated perineal pain persisted for more than one month 17 . Other substances were tried for injection into the prostate in animal models and seemed to be safe, but they are still in the experimental stage (e.g.…”

“…It contributes largely -among other factors -to LUTS in aged men. 1 Treatment modalities of BPH are many and varied and include watchful waiting, which carries a risk of 47% failure with increased post-void residual urine and/or symptom score; medical treatment, which necessitates a life-time commitment and the cooperation of the patient; 10 minimally invasive surgical procedures; 5,[11][12][13] and surgery, which carries the disadvantage of bleeding, TUR syndrome and retrograde ejaculation. 14,15 Various new approaches are being developed for the treatment of BPH.…”