Treatment of Bilharzial Obstructive Uropathy with Praziquantel

Farid, Z.; El-Masry, N. A.; Bassily, S.; Trabolsi, B.; Wallace, C. K.

doi:10.1093/infdis/150.2.307

Cited by 10 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Providing a snack or drink prior to PZQ treatment is reported to improve the drug's efficacy [57]. Some studies reported providing a snack and/or juice before the PZQ treatment [29,37,[57][58][59][60][61][62][63][64], or to have treated participants after their breakfast, lunch or dinner [65][66][67]. However, this could not be taken into account in this analysis as the majority of the studies did not report on supplemental feeding.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy

et al. 2021

View full text Add to dashboard Cite

Background The antihelminthic drug praziquantel has been used as the drug of choice for treating schistosome infection for more than 40 years. Although some epidemiological studies have reported low praziquantel efficacy in cure rate (CR) and/or egg reduction rate (ERR), there is no consistent robust evidence of the development of schistosome resistance to praziquantel (PZQ). There is need to determine factors that lead to variable treatment CR and/or ERR. Therefore, we conducted a systematic review and meta-analysis to review CR and ERR as well as identify their predictors. Methodology/Principal findings In this systematic review and meta-analysis, a literature review was conducted using Biosis Citation Index, Data Citation Index, MEDLINE, and Web of Science Core Collection all of which were provided through Web of Science. Alongside these, EMBASE, and CAB abstracts were searched to identify relevant articles. Random effect meta-regression models were used to identify the factors that influence CR and/or ERR by considering differences in host characteristics and drug dose. In total, 12,127 potential articles were screened and 146 eligible articles (published from 1979 to 2020) were identified and included for the meta-analysis. We found that there has been no significant reduction in CR or ERR over the study period. The results showed more variability in CR, compared with ERR which was more consistent and remained high. The results showed a positive effect of “PZQ treatment dose” with the current recommended dose of 40 mg/kg body weight achieving 57% to 88% CR depending on schistosome species, age of participants, and number of parasitological samples used for diagnosis, and ERR of 95%. Conclusions/Significance Based on a review of over 40 years of research there is no evidence to support concerns about schistosomes developing resistance to PZQ. These results indicate that PZQ remains effective in treating schistosomiasis.

show abstract

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In Grade I there was minimal involvement of the lower endof the ureterwithgranulomatouschanges. These patients were treated with praziquantel (Biltricide) (Smith et al, 1977;Farid et al, 1984). All responded to medical therapy and have been excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

Surgical. Correction of Bilharzial Ureteric Stricture by Boari Flap Technique

Ravi

Motalib

1993

British Journal of Urology

View full text Add to dashboard Cite

Extensive ureteric strictures due to bilharziasis can be managed satisfactorily by reimplantation of the ureters using a Boari flap technique. A series of 150 patients with extensive ureteric strictures underwent ureteric reimplantation using this technique. Contrary to the conventional belief that patients with bilharziasis have a contracted bladder, our patients maintained a good capacity and sufficient supple tissue was available to replace even very extensive ureteric strictures.

show abstract

P

Seyffart

1991

Drug Dosage in Renal Insufficiency

View full text Add to dashboard Cite

Treatment of Bilharzial Obstructive Uropathy with Praziquantel

Cited by 10 publications

References 0 publications

Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy

Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy

Surgical. Correction of Bilharzial Ureteric Stricture by Boari Flap Technique

P

Contact Info

Product

Resources

About